Dentate gyrus network model (Santhakumar et al 2005)

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Mossy cell loss and mossy fiber sprouting are two characteristic consequences of repeated seizures and head trauma. However, their precise contributions to the hyperexcitable state are not well understood. Because it is difficult, and frequently impossible, to independently examine using experimental techniques whether it is the loss of mossy cells or the sprouting of mossy fibers that leads to dentate hyperexcitability, we built a biophysically realistic and anatomically representative computational model of the dentate gyrus to examine this question. The 527-cell model, containing granule, mossy, basket, and hilar cells with axonal projections to the perforant-path termination zone, showed that even weak mossy fiber sprouting (10-15% of the strong sprouting observed in the pilocarpine model of epilepsy) resulted in the spread of seizure-like activity to the adjacent model hippocampal laminae after focal stimulation of the perforant path. See reference for more and details.
Reference:
1 . Santhakumar V, Aradi I, Soltesz I (2005) Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. J Neurophysiol 93:437-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Dentate gyrus;
Cell Type(s): Dentate gyrus granule cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell;
Channel(s): I L high threshold; I T low threshold; I K; I h; I K,Ca; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; neuroConstruct (web link to model);
Model Concept(s): Activity Patterns; Spatio-temporal Activity Patterns; Axonal Action Potentials; Epilepsy; Synaptic Integration;
Implementer(s): Santhakumar, Vijayalakshmi [santhavi at umdnj.edu];
Search NeuronDB for information about:  Dentate gyrus granule cell; GabaA; AMPA; I L high threshold; I T low threshold; I K; I h; I K,Ca; I Calcium; I Potassium;
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dentategyrusnet2005
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Santhakumar V, Aradi I, Soltesz I (2005) Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. J Neurophysiol 93:437-53[PubMed]

References and models cited by this paper

References and models that cite this paper

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   Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007) [Model]

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   Dentate gyrus network model (Tejada et al 2014) [Model]

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   State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013) [Model]

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   Epilepsy may be caused by very small functional changes in ion channels (Thomas et al. 2009) [Model]

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   Na channel mutations in the dentate gyrus (Thomas et al. 2009) [Model]

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   Dentate gyrus network model pattern separation and granule cell scaling in epilepsy (Yim et al 2015) [Model]

Yu J, Proddutur A, Elgammal FS, Ito T, Santhakumar V (2013) Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells. J Neurophysiol 109:1746-63 [Journal] [PubMed]

   [4 reconstructed morphologies on NeuroMorpho.Org]
   Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013) [Model]

(123 refs)