Cortical network model of posttraumatic epileptogenesis (Bush et al 1999)

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Accession:52034
This simulation from Bush, Prince, and Miller 1999 shows the epileptiform response (Fig. 6C) to a brief single stimulation in a 500 cell network of multicompartment models, some of which have active dendrites. The results which I obtained under Redhat Linux is shown in result.gif. Original 1997 code from Paul Bush modified slightly by Bill Lytton to make it work with current version of NEURON (5.7.139). Thanks to Paul Bush and Ken Miller for making the code available.
Reference:
1 . Bush PC, Prince DA, Miller KD (1999) Increased pyramidal excitability and NMDA conductance can explain posttraumatic epileptogenesis without disinhibition: a model. J Neurophysiol 82:1748-58 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex M1 pyramidal pyramidal tract L5B cell; Neocortex M1 pyramidal intratelencephalic L2-5 cell; Neocortex M1 interneuron basket PV cell;
Channel(s): I Na,t; I Sodium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Epilepsy; Synaptic Integration;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Bush, Paul;
Search NeuronDB for information about:  Neocortex M1 pyramidal intratelencephalic L2-5 cell; Neocortex M1 pyramidal pyramidal tract L5B cell; Neocortex M1 interneuron basket PV cell; GabaA; GabaB; AMPA; NMDA; Gaba; I Na,t; I Sodium; I Potassium; Gaba; Glutamate;
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ctxnet
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AMPA.mod
cadecay.mod
cah.mod
dpresyn.mod
fpoisson_generator.mod
GABAa.mod
GABAb.mod
glu.mod
holt_alphasyn.mod
holt_rnd.mod
kca.mod *
kdr.mod
kdrp.mod
na.mod
nap.mod
NMDA.mod
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data.temp
gtstpop.ses
init.hoc
mosinit.hoc *
presyn.inc
result.gif
sns.inc
snsarr.inc
snshead.inc
                            
Simulation based on Fig. 6C of

Bush, PC and Prince, DA and Miller, KD (1999) Increased pyramidal excitability and 
nmda conductance can explain posttraumatic epileptogenesis without disinhibition: 
a model. Journal of Neurophysiology 82:1748-1758

After unzipping the archive and cd'ing to the directory:

To run under unix:  
        nrnivmodl; nrngui init.hoc
On the PC:
	While running mknrndll, cd to ctxnet and select make nrnmech.dll to compile
	the mod files in the ctxnet directory.
	Double click on mosinit.hoc in the ctxnet directory in window explorer
	
On the OS X mac:
	Drag the ctxnet folder to the mknrndll icon under the Neuron 5.7 application.
	When the above is complete drag the ctxnet folder to the nrngui icon.
	
Simulation shows epileptiform response to brief single stimulation in a 500 cell
network of multicompartment models, some of which have active dendrites.

The simulation depends on random number generation so will likely run differently
under different operating systems.  The results which I obtained under Redhat
Linux is shown in result.gif.  The current version can have a couple of lines 
uncommented in holt_random.mod (see comments) to have the seed change each 
time the simulation is run.

Original 1997 code from Paul Bush modified slightly by Bill Lytton to make it work with
current version of NEURON (5.7.139).  Thanks to Paul Bush and Ken Miller for
making the code available.
20110407 updated solve methods to cnexp, derivimplicit from euler
20150219 implements Michael Hine's suggestion to update the DERIVATIVE
block in kca.mod to a form compatible with cnexp

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