Motoneuron simulations for counting motor units (Major and Jones 2005)

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Accession:53425
Simulations of clinical methods to count the number of motoneurons/motor units in human patients. Models include stimulation of motor axons or voluntary activation and responses are measured as muscle tension or EMG.
Reference:
1 . Major LA, Jones KE (2005) Simulations of motor unit number estimation techniques. J Neural Eng 2:17-34 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuromuscular Junction;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Simplified Models; Methods;
Implementer(s): Major, Lora [lora.major at ualberta.ca];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell;
%% ModelDB 

%%--------------------------------------------------------
%% J. Neural Eng. 2 (2005) 17–34
%% "Simulations of motor unit number estimation techniques"
%% AUTHOR: Lora A Major and Kelvin E Jones
%% SUBMITTED:  19NOV2004
%% FIGURE 3
%% MODIFIED DATE: 30MAY2005
%%--------------------------------------------------------

%% define axon diameters (um)
Diams = 4 : 0.5: 16;

%% define axon depths (um) from fascicle survace + 2 mm to skin surface
Depths = [200 : 10 : 400] + 2000;

%% calculate axon tresholds
Is = AxonThresh(Depths,Diams);

figure(3); clf

Is = AxonThresh(Depths, Diams);
surf(Depths, Diams, Is');   axis tight;     axis ij
set(gca, 'YTick', 5:5:15);
view(50, 25)
xlabel('Axon Depth (um)');
ylabel('Axon Diameter (um)');
zlabel('Axon Threshold (mA)');

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