Motoneuron simulations for counting motor units (Major and Jones 2005)

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Accession:53425
Simulations of clinical methods to count the number of motoneurons/motor units in human patients. Models include stimulation of motor axons or voluntary activation and responses are measured as muscle tension or EMG.
Reference:
1 . Major LA, Jones KE (2005) Simulations of motor unit number estimation techniques. J Neural Eng 2:17-34 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuromuscular Junction;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Simplified Models; Methods;
Implementer(s): Major, Lora [lora.major at ualberta.ca];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell;
function Vin = Visolve(Vext,rm,ra,dx);

% solve linear system of equations for intracelular potential

N = length(Vext);

A = sparse([],[],[],N,N,3*N);
A = A + spdiags(repmat(1 + 2*(rm/dx)/(ra*dx),[N 1]),0,N,N) - spdiags(repmat((rm/dx)/(ra*dx),[N 1]),1,N,N) - spdiags(repmat((rm/dx)/(ra*dx),[N-1 1]),-1,N,N);

Vin = [A\Vext']';                        % intracellular potential (mV)

return

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