Paired turbulence and light effect on calcium increase in Hermissenda (Blackwell 2004)

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Accession:53427
The sea slug Hermissenda learns to associate light and hair cell stimulation, but not when the stimuli are temporally uncorrelated...These issues were addressed using a multi-compartmental computer model of phototransduction, calcium dynamics, and ionic currents of the Hermissenda photoreceptor...simulations show that a potassium leak channel, which closes with an increase in calcium, is required to produce both the untrained LLD and the enhanced LLD due to the decrease in voltage dependent potassium currents.
Reference:
1 . Blackwell KT (2004) Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda. J Comput Neurosci 17:81-99 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Hermissenda photoreceptor Type B;
Channel(s): I A; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; GabaB; IP3;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: Chemesis;
Model Concept(s): Temporal Pattern Generation; Invertebrate; Signaling pathways; Calcium dynamics;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  GabaA; GabaB; IP3; I A; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium; Gaba;
//genesis
//kleak-newlig2.g

function make_kleak(path, gbar, vpath)
str	path
float	gbar

float area

if ({vpath} == "/rhab/vm")
    area={rhabSA}/{rhabcyls}
else
    area = {getfield {path} SAout }
end

//echo {vpath} {area}

create ligand2_chan {path}/kleak	/* units are msec, nA, uS, mV */
setfield  {path}/kleak	\
		k1f.min 200e-3 \	
		k1f.max 0.0 \
		k1f.slope -20 \
		k1f.v0 -20.0 \
		k1f.in_exp_power 1 \
		k1f.out_exp_power -1 \
		k1f.in_exp_offset 0 \
		k1f.out_exp_offset 1 \
		k1b.min 1.0e-3 \	
		k1b.max 0.0 \
		k1b.slope 10.0 \
		k1b.v0 -23.0 \
		k1b.in_exp_power 1 \
		k1b.out_exp_power -1 \
		k1b.in_exp_offset 0 \
		k1b.out_exp_offset 1 \
		k2f.min 2000e-3 \	
		k2f.max 0.0 \
		k2f.slope -20 \
		k2f.v0 -20.0 \
		k2f.in_exp_power 1 \
		k2f.out_exp_power -1 \
		k2f.in_exp_offset 0 \
		k2f.out_exp_offset 1 \
		k2b.min 0.1e-3 \	
		k2b.max 0.0 \
		k2b.slope 10.0 \
		k2b.v0 -23.0 \
		k2b.in_exp_power 1 \
		k2b.out_exp_power -1 \
		k2b.in_exp_offset 0 \
		k2b.out_exp_offset 1 \
        	gamma.slope -20 \
        	gamma.min 0 \
        	gamma.max 0 \
		gamma.in_exp_power 1 \
		gamma.out_exp_power -1 \
		gamma.in_exp_offset 0 \
		gamma.out_exp_offset 1 \
        	delta.slope -20 \
        	delta.min 0 \
        	delta.max 0 \
		delta.in_exp_power 1 \
		delta.out_exp_power -1 \
		delta.in_exp_offset 0 \
		delta.out_exp_offset 1 \
		Vr -85.0 \
		rxn_ord1 1 \
		rxn_ord2 1 \
        	cond_state 0 \
		Gbar {gbar*area}

end

/********************************************************************/

function kleak_comp (vpath, capath, startcyl, endcyl, gbar)
str vpath, capath
int startcyl, endcyl
float gbar

int i

  for (i=startcyl; i<=endcyl; i=i+1)
    make_kleak {capath}[{i}] {gbar} {vpath}
    addmsg {capath}[{i}] {capath}[{i}]/kleak LIGAND Conc
    addmsg {vpath} {capath}[{i}]/kleak VOLTAGE Vm
    addmsg {capath}[{i}]/kleak {vpath} CHANNEL G Vr
  end
end

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