S cell network (Moss et al 2005)

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Accession:53559
Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.
Reference:
1 . Moss BL, Fuller AD, Sahley CL, Burrell BD (2005) Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. J Neurophysiol 94:2575-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech S cell;
Channel(s): I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Invertebrate;
Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu];
Search NeuronDB for information about:  I Sodium; I Potassium;
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		>>    MODELE NAME: neu		>>
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>------------------------------->--------------------------------------->
   THRESHOLD:	0.0       	> Threshold for transmitter release	>
>------------------------------->--------------------------------------->
   SPIKDUR:	0.0       	> Spike duration. If equal 0 then	>
				>	actual time when presynaptic	>
				>	neuronis above threshold will	>
				>	be measured			>
>------------------------------->--------------------------------------->
   VMINIT:	-40.0     	> Initial value of membrane potential.	>
>------------------------------->--------------------------------------->
   CM:		0.00016   	> Membrane capacitance.			>
>------------------------------->--------------------------------------->

>------------------------------->--------------------------------------->
   MEM_AREA:        		>     Membrane Area options		>
>------------------------------->--------------------------------------->
>	0			>     do not use membrane area		>
>------------------------------->--------------------------------------->
>	1			>     specify membrane area directly	>
>	1.23            >S<     >     um2				>
>------------------------------->--------------------------------------->
>	2			>     sphere				>
>	20.0            >D<     >     um, diameter			>
>	1.0             >C<     >     invagination factor		>
>------------------------------->--------------------------------------->
	3			>     cylinder				>
	10.0            >D<     >     diameter				>
	500.0           >L<     >     um, length			>
	1		>n<     >     number of ends closed		>
	1.0             >C<     >     invagination factor		>
>------------------------------->--------------------------------------->
>	membrane area is	>     0.000157865     cm*cm		>
>------------------------------->--------------------------------------->


>------------------------------->------------------------------->
   CONDUCTANCES:		>	List of Conductances	>
>------------------------------->------------------------------->
	K			>	Name of conductance	>
	Squid_K.vdg		>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	Na			>	Name of conductance	>
	Squid_Na.vdg		>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	leak			>	Name of conductance	>
	Squid_leak.vdg		>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	END			>				>
>------------------------------->------------------------------->


END

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