S cell network (Moss et al 2005)

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Accession:53559
Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.
Reference:
1 . Moss BL, Fuller AD, Sahley CL, Burrell BD (2005) Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. J Neurophysiol 94:2575-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech S cell;
Channel(s): I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Invertebrate;
Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu];
Search NeuronDB for information about:  I Sodium; I Potassium;
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  LIST_CELLS:		>	Cells	>
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  CHEMSYN:		>	Chemical synapse	>
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  ELCTRCPL:		>	Electrical coupling	>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
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>.......................>...............................>
	END		>				>
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>----------------------->------------------------------->
  MODULSYN:		>	Modulatory synapse	>
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	END		>				>
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  WEIGHT:		>	Weights	>
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	END		>				>
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