S cell network (Moss et al 2005)

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Accession:53559
Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.
Reference:
1 . Moss BL, Fuller AD, Sahley CL, Burrell BD (2005) Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. J Neurophysiol 94:2575-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech S cell;
Channel(s): I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Invertebrate;
Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu];
Search NeuronDB for information about:  I Sodium; I Potassium;
>------------------------------->--------------------------------------->
  VAR_TO_GRAPH: 		>	List of current contributing	>
				>		to ion pools		>
>------------------------------->--------------------------------------->
	GRPH_CHNL:		>	Graph channel			>
>------------------------------->--------------------------------------->
	2			>	GAIN of Channel			>
	time<{ivr}            	>	Var Name for X-axis		>
		6           	>	Number of Tic Marks		>
		0.00        	>	Min Value of X			>
		0.30        	>	Max Value of X			>
		white        	>	Color of Range			>
	V[10d_10....]<{ivr}   	>	Var Name for Y-axis		>
		4           	>	Number of Tic Marks		>
		-90.00      	>	Min Value of Y			>
		70.00       	>	Max Value of Y			>
		green         	>	Color of RAnge			>
>------------------------------->--------------------------------------->
	END:			>					>
>------------------------------->--------------------------------------->

>------------------------------->--------------------------------------->
   VAR_TO_FILE: 		>	List of current contributing	>
>				>		to ion pools		>
>------------------------------->--------------------------------------->
	time<{ivr}             	>	VAR name			>
	V[10_1....]<{ivr}      	>	VAR name			>
>------------------------------->--------------------------------------->
	END:			>					>
>------------------------------->--------------------------------------->

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