S cell network (Moss et al 2005)

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Accession:53559
Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.
Reference:
1 . Moss BL, Fuller AD, Sahley CL, Burrell BD (2005) Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. J Neurophysiol 94:2575-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech S cell;
Channel(s): I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Invertebrate;
Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu];
Search NeuronDB for information about:  I Sodium; I Potassium;
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>----------------------->------------------------------->
  LOGICAL_NAME:         >       Name of Network         >
>.......................>...............................>
       Eletrotonic_cable> The name of the network       >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TIMING:               > Timing information in seconds >
>.......................>...............................>
        0.0000000000    > What value to assign to the   >
                        > variable 'time' at time=0     >
>.......................>...............................>
        0.3000000000    > When to stop the simulation   >
>.......................>...............................>
        0.0000100000    > Step size (h)                 >
>----------------------->------------------------------->

>----------------------->------------------------------->
  ON_LINE_GRAPH:        >       On-line graph           >
>.......................>...............................>
        1               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  STORE_RESULTS:        >       Store results           >
>.......................>...............................>
        1               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  INT_METHOD:           >       Integration method      >
>.......................>...............................>
        1               > 1 for Euler method            >
                        > 2 for RK                      >
                        > 3 for RKQC                    >
>----------------------->------------------------------->

>----------------------->------------------------------->
  NETWORK:              > Structure of network          >
>.......................>...............................>
        Cable_10.ntw    > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  OUTPUT_SETUP:         > List of variables for output  >
>.......................>...............................>
        Cable_10.ous    > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TREATMENTS:           > External treatments           >
>.......................>...............................>
        Cable_10.trt    > the name of the file          >
>----------------------->------------------------------->
  INT_&_FIRE:           >       Integration method      >
>.......................>...............................>
        0.0020000000    > Integrate And Fire step_size  >
>----------------------->------------------------------->

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