S cell network (Moss et al 2005)

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Accession:53559
Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.
Reference:
1 . Moss BL, Fuller AD, Sahley CL, Burrell BD (2005) Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. J Neurophysiol 94:2575-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech S cell;
Channel(s): I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Invertebrate;
Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu];
Search NeuronDB for information about:  I Sodium; I Potassium;
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        10a_5           > Name of Neuron                >
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        0.035           >       Start injection         >
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        0.07            >       Start injection         >
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        10a_5           > Name of Neuron                >
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        0.166           >       Start injection         >
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        0.098           >       Start injection         >
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        0.0985          >       Stop injection          >
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        0.045           >       Start injection         >
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        10b_5           > Name of Neuron                >
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        0.151           >       Start injection         >
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        0.1515          >       Stop injection          >
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        0.012           >       Start injection         >
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        0.002           >       Start injection         >
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        10c_5           > Name of Neuron                >
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        0.181           >       Start injection         >
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        0.1815          >       Stop injection          >
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        10.00           >       Magnitude               >
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        10c_5           > Name of Neuron                >
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        0.252           >       Start injection         >
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        0.2525          >       Stop injection          >
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