S cell network (Moss et al 2005)

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Accession:53559
Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.
Reference:
1 . Moss BL, Fuller AD, Sahley CL, Burrell BD (2005) Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. J Neurophysiol 94:2575-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech S cell;
Channel(s): I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Invertebrate;
Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu];
Search NeuronDB for information about:  I Sodium; I Potassium;
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m:		> 	Activation function (rate constant method)	>
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>----------------------->--------------------------------------->
>	1		>	     am				>
>			>	m= --------		     (1)>
>			>	    am+bm			>
>			>					>
>----------------------->--------------------------------------->
>	2		>	dm/dt=am x (1-m) - bm x m    (2)>
>	xxx.xx	>IV<	>					>
>----------------------->--------------------------------------->
	3		>    dm/dt=L[am x (1-m) - bm x m] (3)   >
	-1.0	>IV<	>					>
	4040.0	>1000 L<	>					>
>----------------------->--------------------------------------->



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am:		> 	Rate parameter (1)				>	
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>----------------------->----------------------------------------------->
>	1		>	         			(1)	>
>	xxx.xx	>A<	>	am = A        				>
>----------------------->----------------------------------------------->
>	2		>		A (V+B)				>
>	xxx.xx	>A<	>	am = --------------------	(2)	>
>	xxx.xx	>B<	>	          (C-V)/D 			>
>	xxx.xx	>C<	>	     1 + e        			>
>	xxx.xx	>D<	>						>
>			>						>
>----------------------->----------------------------------------------->
	3		>		A (V+B)				>
	0.01	>.01 A<	>	am = --------------------	(3)	>
	50.01	>50 B<	>	          (C-V)/D 			>
	-50.01	>-50 C<	>	     1 - e        			>
	10.0	>10 D<	>						>
			>						>
>----------------------->----------------------------------------------->
>	4		>	          (A-V)/B 		(4)	>
>	xxx.xx	>A<	>	am = 1 + e        			>
>	xxx.xx	>B<	>						>
>			>						>
>----------------------->----------------------------------------------->
>	5		>	         (B-V)/C 		(5)	>
>	xxx.xx	>A<	>	am = A e        			>
>	xxx.xx	>B<	>						>
>	xxx.xx	>C<	>						>
>----------------------->----------------------------------------------->
>	6		>		A 				>
>	xxx.xx	>A<	>	am = --------------------	(6)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	7		>		A 				>
>	xxx.xx	>A<	>	am = --------------------	(7)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->
>	8		>		1 				>
>	xxx.xx	>A<	>	am = --------------------	(8)	>
>	xxx.xx	>B<	>	          (A-V)/B 			>
>			>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	9		>		1 				>
>	xxx.xx	>A<	>	am = --------------------	(9)	>
>	xxx.xx	>B<	>	          (A-V)/B 			>
>			>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->

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bm:		> 	Rate parameter (2)				>	
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>----------------------->----------------------------------------------->
>	1		>	         			(1)	>
>	xxx.xx	>A<	>	bm = A        				>
>----------------------->----------------------------------------------->
>	2		>		A (V+B)				>
>	xxx.xx	>A<	>	bm = --------------------	(2)	>
>	xxx.xx	>B<	>	          (C-V)/D 			>
>	xxx.xx	>C<	>	     1 + e        			>
>	xxx.xx	>D<	>						>
>			>						>
>----------------------->----------------------------------------------->
>	3		>		A (V+B)				>
>	xxx.xx	>A<	>	bm = --------------------	(3)	>
>	xxx.xx	>B<	>	          (C-V)/D 			>
>	xxx.xx	>C<	>	     1 - e        			>
>	xxx.xx	>D<	>						>
>			>						>
>----------------------->----------------------------------------------->
>	4		>	          (A-V)/B 		(4)	>
>	xxx.xx	>A<	>	bm = 1 + e        			>
>	xxx.xx	>B<	>						>
>			>						>
>----------------------->----------------------------------------------->
	5		>	         (B-V)/C 		(5)	>
	0.125	>.125 A<	>	bm = A e        			>
	-60.0	>-60 B<	>						>
	80.0	>80 C<	>						>
>----------------------->----------------------------------------------->
>	6		>		A 				>
>	xxx.xx	>A<	>	bm = --------------------	(6)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	7		>		A 				>
>	xxx.xx	>A<	>	bm = --------------------	(7)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->
>	8		>		1 				>
>	xxx.xx	>A<	>	bm = --------------------	(8)	>
>	xxx.xx	>B<	>	          (A-V)/B 			>
>			>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	9		>		1 				>
>	xxx.xx	>A<	>	bm = --------------------	(9)	>
>	xxx.xx	>B<	>	          (A-V)/B 			>
>			>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->

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