S cell network (Moss et al 2005)

 Download zip file 
Help downloading and running models
Accession:53559
Excerpts from the abstract: S cells form a chain of electrically coupled neurons that extends the length of the leech CNS and plays a critical role in sensitization during whole-body shortening. ... Serotonin ... increasedAP latency across the electrical synapse, suggesting that serotonin reduced coupling between S cells. ... Serotonin modulated instantaneous AP frequency when APs were initiated in separate S cells and in a computational model of S cell activity following mechanosensory input. Thus, serotonergic modulation of S cell electrical synapses may contribute to changes in the pattern of activity in the S cell network. See paper for more.
Reference:
1 . Moss BL, Fuller AD, Sahley CL, Burrell BD (2005) Serotonin modulates axo-axonal coupling between neurons critical for learning in the leech. J Neurophysiol 94:2575-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech S cell;
Channel(s): I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Invertebrate;
Implementer(s): Baxter, Douglas; Moss, Brenda [bmoss at usd.edu]; Byrne, John [john.h.byrne at uth.tmc.edu];
Search NeuronDB for information about:  I Sodium; I Potassium;
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>    modules name: es		>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Ies:		> 	Current due to electrical synapse		>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

>------------------------------->--------------------------------------->
	1			>	Ies(1) = G1 x (V1 -V2)	(1)	>
				>					>
	0.196		>G1<	>	Ies(2) = G2 x (V2 -V1)		>
	0.196		>G2<	>			 		>
				>					>
>------------------------------->--------------------------------------->

END:


Loading data, please wait...