A model for interaural time difference sensitivity in the medial superior olive (Zhou et al 2005)

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Accession:53869
This model simulates responses of neurons to interaural time difference (ITD) in the medial superior olive (MSO) of the mammalian brainstem. The model has a bipolar cell structure and incorporates two anatomic observations in the MSO: (1) the axon arises from the dendrite that receives ipsilateral inputs and (2) inhibitory synapses are located primarily on the soma in adult animals. Fine adjustment of the best ITD is achieved by the interplay of somatic sodium currents and synaptic inhibitory currents. The model suggests a mechanism for dynamically "fine-tuning" the ITD sensitivity of MSO cells by the opponency between depolarizing sodium currents and hyperpolarizing inhibitory currents.
Reference:
1 . Zhou Y, Carney LH, Colburn HS (2005) A model for interaural time difference sensitivity in the medial superior olive: interaction of excitatory and inhibitory synaptic inputs, channel dynamics, and cellular morphology. J Neurosci 25:3046-58 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Medial Superior Olive (MSO) cell;
Channel(s): I h; I Sodium; I Potassium;
Gap Junctions:
Receptor(s): AMPA; Glycine;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Coincidence Detection; Axonal Action Potentials;
Implementer(s): Zhou, Yi [yizhou at bu.edu];
Search NeuronDB for information about:  AMPA; Glycine; I h; I Sodium; I Potassium;
load_file("nrngui.hoc")

strdef tstr

xpanel("Figures for Zhou et al 2005")
xlabel("Press a button to create the figure")
xradiobutton("Main simulation", "restart(\"MSO_Zhouetal_2005\")")
xradiobutton("Additional simulation", "restart(\"test_inputs\")")
xlabel("After you click on one of the above buttons you will be asked")
xlabel("to enter a number which will be used to seed the random number")
xlabel("generator.  After you have entered the number please press the")
xlabel("\"Single Run\" button which will appear in a Control window")
xlabel("Note: the main simulation takes 3 1/4 minutes on a 2Ghz machine")
xlabel("and the additional simulation takes less than 15 seconds.")
xpanel(5,100)

pwmcnt = PWManager[0].count // the initial gui should not be dismissed

proc restart() {local i
	objref graphItem, save_window_
	for i=0, n_graph_lists-1 {
		graphList[i].remove_all()
	}
	flush_list.remove_all()
	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
	
	sprint(tstr, "%s.hoc", $s1)
	load_file(1, tstr)
}

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