Medial vestibular neuron models (Quadroni and Knopfel 1994)

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Accession:53876
The structure and the parameters of the model cells were chosen to reproduce the responses of type A and type B MVNns as described in electrophysiological recordings. The emergence of oscillatory firing under these two specific experimental conditions is consistent with electrophysiological recordings not used during construction of the model. We, therefore, suggest that these models have a high predictive value.
Reference:
1 . Quadroni R, Knöpfel T (1994) Compartmental models of type A and type B guinea pig medial vestibular neurons. J Neurophysiol 72:1911-24 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Vestibular neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Action Potentials; Calcium dynamics;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
This document records measurements from the figures in the paper
Quadroni and Knopfel 1994 and the current
state of the model implemented by Tom Morse

fig 3a		PAPER		MODEL
graph scale bars

b=20(mV)/21.5(mm)
c=2ms/30mm
d=100nM/11mm

Peak to trough
AP height	84.5mm*(b)=78.6 76.33
AP width	9*c=0.6 ms		.65 ms

[Ca]i height	71*d=645nM	611.9e-6 mM= 611.9 nM
[Ca]i width	10*d= 0.67 ms	0.76 ms

fig3b
f=5nA/21.5mm

IKfast height	30*f=6.98 nA	0.250 mA/cm2
INa height	50*f=11.627 nA	-0.414 mA/cm2
ratios		30/50=0.6	250/414=0.604

fig3C
g=0.5nA/30.5mm
IKAHP height	14.5*g=0.2377	0.0186 mA/cm2 + shape of current is not right
IKA height	10.5*g=0.17213	0.01847 mA/cm2
ICaHVA height	32*g = 0.52459	-0.01663 mA/cm2
KA/CaHVA ratios:
		0.17213/0.5249=0.3279
		0.01847/0.01663=1.111
fig4D
j=0.1nA/32mm
IKslow height	19*j=0.059375	0.001314 mA/cm2
Ih delta	2.5*j=0.0078125	303.6 nA/cm2
INaP delta	18*j=0.05625	 0.00184332 mA/cm2

ratios
IKslow/NaP	0.059375/0.05625 0.001314/0.00184332

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