Medial vestibular neuron models (Quadroni and Knopfel 1994)

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Accession:53876
The structure and the parameters of the model cells were chosen to reproduce the responses of type A and type B MVNns as described in electrophysiological recordings. The emergence of oscillatory firing under these two specific experimental conditions is consistent with electrophysiological recordings not used during construction of the model. We, therefore, suggest that these models have a high predictive value.
Reference:
1 . Quadroni R, Knöpfel T (1994) Compartmental models of type A and type B guinea pig medial vestibular neurons. J Neurophysiol 72:1911-24 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Vestibular neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Action Potentials; Calcium dynamics;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
// nmda_offon.hoc
// procedures to turn nmda conductances off and on

// if nmda receptors are on this is the value used everywhere:

gbar_nmda_const = 0.002570 // S/cm2

proc A_nmda_off() {
	forsec A_prox_sects {gbar_nmda=0}
	forsec A_dist_sects {gbar_nmda=0}
}

proc A_nmda_on() {
	forsec A_prox_sects {gbar_nmda=gbar_nmda_const}
	forsec A_dist_sects {gbar_nmda=gbar_nmda_const}
}

proc B_nmda_off() {
	forsec B_prox_sects {gbar_nmda=0}
	forsec B_dist_sects {gbar_nmda=0}
}

proc B_nmda_on() {
	forsec B_prox_sects {gbar_nmda=gbar_nmda_const}
	forsec B_dist_sects {gbar_nmda=gbar_nmda_const}
}

proc nmda_off() {
	A_nmda_off()
	B_nmda_off()
}
proc nmda_on() {
	A_nmda_on()
	B_nmda_on()
}

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