T channel currents (Vitko et al 2005)

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Accession:53965
Computer simulations predict that seven of the SNPs would increase firing of neurons, with three of them inducing oscillations at similar frequencises. 3 representative models from the paper have been submited: a wild-type (WT) recombinant Cav3.2 T-channel, and two of the mutants described in the Vitko et al., 2005 paper (C456S and R788C). See the paper for more and details.
Reference:
1 . Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci 25:4844-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Epilepsy;
Implementer(s):
Search NeuronDB for information about:  I T low threshold;
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zippedModels
Cav32_WT
cells
README *
capump.mod *
HH2.mod *
IT2.mod
VClamp.mod *
El.oc *
Hh8.ses
hH80_2.jpg
Hh8ips2.jpg
Hh8triple.jpg
leak.oc *
loc3.oc *
loc80.oc *
locD.oc *
mosinit.hoc *
re1_cc.oc *
re3_cc.oc *
re3_vc.oc *
re80_cc.oc *
re80_vc.oc *
reD_cc.oc *
reD_vc.oc *
rundemo.hoc *
WtEP2.jpg
                            
/*----------------------------------------------------------------------

  Procedure for localizing T-current in distal dendrites

	- Reconstructed thalamic RE cell with 80 compartments (re80)
	- currents must be localized everywhere

	first parameter: somatic and proximal dendritic conductance
	secnd parameter: medial dendritic conductance
	third parameter: distal dendritic conductance

----------------------------------------------------------------------*/

proc localize() {

	/* CHANGE ALL : */

		forall { gcabar_it2 = $3 }



	/* CHANGE SOMA : */

		soma.gcabar_it2 = $1


	/* CHANGE PROXIMAL SEGMENTS : */

		dend1[0].gcabar_it2 = $1
		dend1[1].gcabar_it2 = $1
		dend1[2].gcabar_it2 = $1
		dend1[22].gcabar_it2 = $1

		dend2[0].gcabar_it2 = $1

		dend3[0].gcabar_it2 = $1

		dend4[0].gcabar_it2 = $1



	/* CHANGE MEDIAL SEGMENTS : */

		dend1[3].gcabar_it2 = $2
		dend1[16].gcabar_it2 = $2
		dend1[17].gcabar_it2 = $2
		dend1[18].gcabar_it2 = $2
		dend1[19].gcabar_it2 = $2
		dend1[23].gcabar_it2 = $2
		dend1[34].gcabar_it2 = $2

		dend2[1].gcabar_it2 = $2
		dend2[4].gcabar_it2 = $2

		dend3[1].gcabar_it2 = $2
		dend3[10].gcabar_it2 = $2

		dend4[1].gcabar_it2 = $2
		dend4[2].gcabar_it2 = $2

}




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