T channel currents (Vitko et al 2005)

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Accession:53965
Computer simulations predict that seven of the SNPs would increase firing of neurons, with three of them inducing oscillations at similar frequencises. 3 representative models from the paper have been submited: a wild-type (WT) recombinant Cav3.2 T-channel, and two of the mutants described in the Vitko et al., 2005 paper (C456S and R788C). See the paper for more and details.
Reference:
1 . Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci 25:4844-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Epilepsy;
Implementer(s):
Search NeuronDB for information about:  I T low threshold;
/
zippedModels
Cav32_R788C
cells
README *
capump.mod *
HH2.mod *
IT2.mod
VClamp.mod *
El.oc *
leak.oc *
loc3.oc *
loc80.oc *
locD.oc *
mosinit.hoc *
R788Cep.jpg
R788Cip.jpg
re1_cc.oc *
re3_cc.oc *
re3_vc.oc *
re80_cc.oc *
re80_vc.oc *
reD_cc.oc *
reD_vc.oc *
rundemo.hoc *
                            
 NEURON TUTORIAL FOR IMPLEMENTING SIMULATIONS OF THALAMIC RETICULAR NEURONS

                          Alain Destexhe
		Laboratory for Computational Neuroscience
	Unité de Neurosciences Intégratives et Computationnelles (UNIC)
	Centre National de la Recherche Scientifique (CNRS)
			91198 Gif-sur-Yvette, France 

	    Formerly from (when this work was created):
            Department of Physiology, Laval University,
                      Quebec G1K 7P4, Canada

                       Destexhe@iaf.cnrs-gif.fr
                     http://cns.iaf.cnrs-gif.fr/Main.html


This package is running with the NEURON simulation program written by Michael
Hines and available on internet at:
  http://www.neuron.yale.edu/neuron/
  http://neuron.duke.edu/

The package contains mechanisms (.mod files) and programs (.oc files) needed to
simulate different models of thalamic reticular (RE) neurons, relative to the
paper:

  Destexhe A, Contreras D, Steriade M, Sejnowski TJ and Huguenard JR.  
  In vivo, in vitro and computational analysis of dendritic calcium currents 
  in thalamic reticular neurons.  Journal of Neuroscience 16: 169-185, 1996.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8613783&query_hl=7


A postscript version of this paper, including figures, is available on
internet at 
  http://cns.iaf.cnrs-gif.fr/Main.html
  
  PROGRAMS
  ========

re1_cc.oc  : current clamp in one-compartment RE cell
re3_cc.oc  : current clamp in 3-compartment RE cell
re3_vc.oc  : voltage clamp in 3-compartment RE cell
re80_cc.oc : current clamp in 80-compartment RE cell
re80_vc.oc : voltage clamp in 80-compartment RE cell
reD_cc.oc  : current clamp in 8-compartment RE cell (dissociated cell)
reD_vc.oc  : voltage clamp in 8-compartment RE cell (dissociated cell)


  MECHANISMS
  ==========

 HH2.mod		: fast sodium spikes (Na and K currents)
 IT2.mod		: T-type calcium current of RE cells
 capump.mod		: intracellular calcium dynamics
 VClamp.mod		: mechanism for single-electrode voltage-clamp


  HOW TO RUN
  ==========

Use autolaunch on modeldb or:

unix platform:

  To compile the demo, NEURON and INTERVIEWS must be installed and working on
  the machine you are using.  Just type "nrnivmodl" to compile the mechanisms
  given in the mod files.

  Then, execute the main demo program by typing:

  nrngui mosinit.hoc

mswin platform:

  Compile the mechanism (mod) files by using mknrndll.  Then start the simulation
  by clicking on mosinit.hoc in windows explorer.

After either of the above platforms instructions: 

Once the menu and graphics interface has appeared, click on "Init and Run" button
or if appropriate ""Start protocol" for voltage clamp families, to start the simulation...

For more information about how to get NEURON and how to install it, please
refer to the following sites:
  http://www.neuron.yale.edu/neuron/
  http://neuron.duke.edu/

For further information, please contact:

Alain Destexhe
Laboratory for Computational Neuroscience
Unité de Neurosciences Intégratives et Computationnelles (UNIC)
Centre National de la Recherche Scientifique (CNRS)
91198 Gif-sur-Yvette, France 

Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr/Main.html

Updated 7/10/05 for button restart fix.


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