T channel currents (Vitko et al 2005)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:53965
Computer simulations predict that seven of the SNPs would increase firing of neurons, with three of them inducing oscillations at similar frequencises. 3 representative models from the paper have been submited: a wild-type (WT) recombinant Cav3.2 T-channel, and two of the mutants described in the Vitko et al., 2005 paper (C456S and R788C). See the paper for more and details.
Reference:
1 . Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci 25:4844-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Epilepsy;
Implementer(s):
Search NeuronDB for information about:  I T low threshold;
/
zippedModels
Cav32_R788C
cells
README *
capump.mod *
HH2.mod *
IT2.mod
VClamp.mod *
El.oc *
leak.oc *
loc3.oc *
loc80.oc *
locD.oc *
mosinit.hoc *
R788Cep.jpg
R788Cip.jpg
re1_cc.oc *
re3_cc.oc *
re3_vc.oc *
re80_cc.oc *
re80_vc.oc *
reD_cc.oc *
reD_vc.oc *
rundemo.hoc *
                            
/*----------------------------------------------------------------------

  Procedure for localizing T-current in distal dendrites

	- Model of dissociated thalamic RE cell with 8 compartments
	- currents must be localized everywhere

	first parameter: somatic and proximal conductance
	secnd parameter: medial dendritic conductance

  In the dissociated cell, the soma, dend1[0,1,2,3] and dend3[0,1,7] were
  kept from the original and renamed soma, dend1[0,1,2,3], and dend2[0,1,2],
  repectively.


----------------------------------------------------------------------*/

proc localize() {

	/* CHANGE ALL : */

		forall { gcabar_it2 = $2 }


	/* CHANGE SOMA : */

		soma.gcabar_it2 = $1


	/* CHANGE PROXIMAL SEGMENTS : */

		dend1[0].gcabar_it2 = $1
		dend1[1].gcabar_it2 = $1
		dend1[2].gcabar_it2 = $1	// same as re80

		dend2[0].gcabar_it2 = $1	// same as dend3[0] in re80

}




Loading data, please wait...