T channel currents (Vitko et al 2005)

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Accession:53965
Computer simulations predict that seven of the SNPs would increase firing of neurons, with three of them inducing oscillations at similar frequencises. 3 representative models from the paper have been submited: a wild-type (WT) recombinant Cav3.2 T-channel, and two of the mutants described in the Vitko et al., 2005 paper (C456S and R788C). See the paper for more and details.
Reference:
1 . Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci 25:4844-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Epilepsy;
Implementer(s):
Search NeuronDB for information about:  I T low threshold;
/
zippedModels
Cav32_R788C
cells
README *
capump.mod *
HH2.mod *
IT2.mod
VClamp.mod *
El.oc *
leak.oc *
loc3.oc *
loc80.oc *
locD.oc *
mosinit.hoc *
R788Cep.jpg
R788Cip.jpg
re1_cc.oc *
re3_cc.oc *
re3_vc.oc *
re80_cc.oc *
re80_vc.oc *
reD_cc.oc *
reD_vc.oc *
rundemo.hoc *
                            
//----------------------------------------------------------------------------
//  define a panel to run the different demos
//----------------------------------------------------------------------------

strdef tstr
ismenu=0
pwmcnt = PWManager[0].count // the initial gui should not be dismissed

objref El

electrodes_present=0	// after electrodes are created they must be
			// destroyed if simulation restarted

proc destroy_elec() {
	execute("objref stim, vc",El)
}

proc restart() {local i

	if (electrodes_present) {
		destroy_elec()
	}

	forall delete_section()

	objref graphItem, save_window_
	for i=0, n_graph_lists-1 {
		graphList[i].remove_all()
	}
	flush_list.remove_all()
	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
	
	sprint(tstr, "%s.oc", $s1)
	load_file(1, tstr)
}

proc make_demopanel() {
	xpanel("Simulations of TC cells")
// xradiobutton("7", "restart(\"makefig7\")")

	xbutton("Burst behavior in single-compartment model","restart(\"re1_cc\")")
	xbutton("Burst behavior in 3-compartment model","restart(\"re3_cc\")")
        xbutton("Voltage-clamp in 3-compartment cell model","restart(\"re3_vc\")")
        xbutton("Burst behavior in detailed cell model","restart(\"re80_cc\")")
        xbutton("Voltage-clamp in detailed cell model","restart(\"re80_vc\")")
        xbutton("Burst behavior in dissociated cell model","restart(\"reD_cc\")")
        xbutton("Voltage-clamp in dissociated cell model","restart(\"reD_vc\")")
	xpanel()
}

make_demopanel()

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