Persistent synchronized bursting activity in cortical tissues (Golomb et al 2005)

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Accession:57905
The program simulates a one-dimensional model of a cortical tissue with excitatory and inhibitory populations.
Reference:
1 . Golomb D, Shedmi A, Curtu R, Ermentrout GB (2006) Persistent synchronized bursting activity in cortical tissues with low magnesium concentration: a modeling study J Neurophysiol 95:1049-1067 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Abstract Wang-Buzsaki neuron;
Channel(s): I Na,p; I Na,t; I K; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: C or C++ program;
Model Concept(s): Bursting; Oscillations; Synchronization; Epilepsy;
Implementer(s): Golomb, David [golomb at bgu.ac.il];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; GabaA; AMPA; NMDA; I Na,p; I Na,t; I K; I K,leak; I M; Gaba; Glutamate;
  
Model of a one-dimensional cortical network, according to the paper:

Golomb D, Shedmi A, Curtu R, Ermentrout B (2005)
Persistent synchronized bursting activity in cortical tissues with low
magnesium concentration: a modeling study
J. Neurophysiol. published 19 October 2005, 10.1152/jn.00932.2005

The program is composed of several C files:

sp.c  : main file. It is used for running several parameter sets.
sn.c  : runs one parameter set.
sgy.c : routines for the excitatory cell model.
swb.c : routines for the inhibitory cell model.
nr.c  : routines from the library "Numerical Recipes" (only few of them
        are needed for this program).

The files sp.n.a3 and sp.n.a4 are parameter files.

Commands (for a Unix/Linux operating system):

To compile the program

make sp

to run the program for the two data files

sp.ex a3
sp.ex a4

to generate figure 12 in the paper (you should have the graphic program
xmgrace):

rasei.com

The file rasei.com is a Unix/Linux command procedure.

If you have problems, E-mail me to golomb@bgu.ac.il

  David Golomb

Golomb D, Shedmi A, Curtu R, Ermentrout GB (2006) Persistent synchronized bursting activity in cortical tissues with low magnesium concentration: a modeling study J Neurophysiol 95:1049-1067[PubMed]

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