Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

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We use a combination of dynamical analysis and electrophysiological recordings to demonstrate that spike broadening in dendrites is primarily caused by a cumulative inactivation of dendritic Na(+) current. We further show that a reduction in dendritic Na(+) current increases excitability by decreasing the interspike interval (ISI) and promoting burst firing.
Reference:
1 . Fernandez FR, Mehaffey WH, Turner RW (2005) Dendritic na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential. J Neurophysiol 94:3836-48 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): ELL pyramidal cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites;
Implementer(s): Fernandez FR [ffernand at ucalgary.ca]; Mehaffey WH ;
Search NeuronDB for information about:  I Na,t; I K;
  
/
na_excit
readme.txt
ELLburstpyramidal.m
ELLburstpyramidal_noSigProcToolbox.m
fig2b.jpg
                            
This is the readme for the model associated with the paper:

Fernandez FR, Mehaffey WH, Turner RW (2005) Dendritic na+ current
inactivation can increase cell excitability by delaying a somatic
depolarizing afterpotential. J Neurophysiol 94:3836-48

Hotchkiss Brain Institute, University of Calgary, 3330 Hospital
Dr. N.W., Calgary, Alberta T2N 4N1, Canada.
rwturner@ucalgary.ca.

Many central neurons support active dendritic spike
backpropagation mediated by voltage-gated currents. Active spikes
in dendrites have been shown capable of providing feedback to the
soma to influence somatic excitability and firing dynamics
through a depolarizing afterpotential (DAP). In pyramidal cells
of the electrosensory lobe of weakly electric fish, Na(+) spikes
in dendrites undergo a frequency-dependent broadening that
enhances the DAP to increase somatic firing frequency. We use a
combination of dynamical analysis and electrophysiological
recordings to demonstrate that spike broadening in dendrites is
primarily caused by a cumulative inactivation of dendritic Na(+)
current. We further show that a reduction in dendritic Na(+)
current increases excitability by decreasing the interspike
interval and promoting burst firing. This process arises when
inactivation of dendritic Na(+) current shifts the latency of the
dendritic spike to delay the arrival of the DAP sufficiently to
increase its impact on somatic membrane potential despite a
reduction in dendritic excitability. Furthermore, the
relationship between dendritic Na(+) current density and somatic
excitability is nonmonotonic, as intermediate levels of dendritic
Na(+) current exert the greatest excitatory influence. These
results reveal that temporal shifts in dendritic spike firing
provide a novel means for backpropagating spikes to influence the
final output of a cell.

These files were supplied by Dr Fernandez
ffernand@ucalgary.ca

If you have the sigmal processing toolbox you can run the matlab 
program ELLburstpyramidal.m, otherwise run the matlab program 
ELLburstpyramidal_noSigProcToolbox.m

Fernandez FR, Mehaffey WH, Turner RW (2005) Dendritic na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential. J Neurophysiol 94:3836-48[PubMed]

References and models cited by this paper

References and models that cite this paper

Aldrich RW, Getting PA, Thompson SH (1979) Mechanism of frequency-dependent broadening of molluscan neurone soma spikes. J Physiol 291:531-44 [PubMed]

Azouz R, Gray CM (2000) Dynamic spike threshold reveals a mechanism for synaptic coincidence detection in cortical neurons in vivo. Proc Natl Acad Sci U S A 97:8110-5 [PubMed]

Chacron MJ, Doiron B, Maler L, Longtin A, Bastian J (2003) Non-classical receptive field mediates switch in a sensory neuron's frequency tuning. Nature 423:77-81 [PubMed]

Colbert CM, Magee JC, Hoffman DA, Johnston D (1997) Slow recovery from inactivation of Na+ channels underlies the activity-dependent attenuation of dendritic action potentials in hippocampal CA1 pyramidal neurons. J Neurosci 17:6512-21 [PubMed]

Dan Y, Poo MM (2004) Spike timing-dependent plasticity of neural circuits. Neuron 44:23-30 [PubMed]

Doedel EJ (1981) AUTO: a program for the automatic bifurcation analysis of autonomous systems. Congressus Numerantium 30:265-284

Doiron B, Laing C, Longtin A, Maler L (2002) Ghostbursting: a novel neuronal burst mechanism. J Comput Neurosci 12:5-25 [Journal] [PubMed]

Doiron B, Longtin A, Turner RW, Maler L (2001) Model of gamma frequency burst discharge generated by conditional backpropagation. J Neurophysiol 86:1523-45 [Journal] [PubMed]

Ermentrout B (1996) Type I membranes, phase resetting curves, and synchrony. Neural Comput 8:979-1001 [PubMed]

Ermentrout GB (2002) Simulating, Analyzing, and Animating Dynamical System: A Guide to XPPAUT for Researchers and Students Society for Industrial and Applied Mathematics (SIAM)

Fernandez FR, Mehaffey WH, Molineux ML, Turner RW (2005) High-threshold K+ current increases gain by offsetting a frequency-dependent increase in low-threshold K+ current. J Neurosci 25:363-71 [PubMed]

   Pyramidal neurons: IKHT offsets activation of IKLT to increase gain (Fernandez et al 2005) [Model]

Fernandez FR, Morales E, Rashid AJ, Dunn RJ, Turner RW (2003) Inactivation of Kv3.3 potassium channels in heterologous expression systems. J Biol Chem 278:40890-8 [PubMed]

Fleidervish IA, Friedman A, Gutnick MJ (1996) Slow inactivation of Na+ current and slow cumulative spike adaptation in mouse and guinea-pig neocortical neurones in slices. J Physiol 493 ( Pt 1):83-97 [PubMed]

Gabbiani F, Metzner W, Wessel R, Koch C (1996) From stimulus encoding to feature extraction in weakly electric fish. Nature 384:564-7 [PubMed]

Golding NL, Jung HY, Mickus T, Spruston N (1999) Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. J Neurosci 19:8789-98 [PubMed]

Hansel D, Mato G, Meunier C (1995) Synchrony in excitatory neural networks. Neural Comput 7:307-37 [PubMed]

Hille B (2001) Classic mechanisms of block Ion Channels of Excitable Membranes (3rd edn) :503-537

Jung HY, Mickus T, Spruston N (1997) Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons. J Neurosci 17:6639-46 [PubMed]

Laing CR, Doiron B, Longtin A, Noonan L, Turner RW, and Maler L (2003) Type I Burst Excitability Journal of Computational Neuroscience 14:329-342 [Journal]

Larkum ME, Zhu JJ, Sakmann B (1999) A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature 398:338-41 [PubMed]

Lemon N, Turner RW (2000) Conditional spike backpropagation generates burst discharge in a sensory neuron. J Neurophysiol 84:1519-30 [Journal] [PubMed]

Ma M, Koester J (1995) Consequences and mechanisms of spike broadening of R20 cells in Aplysia californica. J Neurosci 15:6720-34 [PubMed]

Ma M, Koester J (1996) The role of K+ currents in frequency-dependent spike broadening in Aplysia R20 neurons: a dynamic-clamp analysis. J Neurosci 16:4089-101 [PubMed]

Magee JC, Carruth M (1999) Dendritic voltage-gated ion channels regulate the action potential firing mode of hippocampal CA1 pyramidal neurons. J Neurophysiol 82:1895-901 [Journal] [PubMed]

Magee JC, Johnston D (1995) Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons. Science 268:301-4 [PubMed]

Magee JC, Johnston D (1997) A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons. Science 275:209-13 [PubMed]

Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 [Journal] [PubMed]

   [2 reconstructed morphologies on NeuroMorpho.Org]
   Pyramidal Neuron Deep, Superficial; Aspiny, Stellate (Mainen and Sejnowski 1996) [Model]

Nadal MS, Ozaita A, Amarillo Y, Vega-Saenz de Miera E, Ma Y, Mo W, Goldberg EM, Misumi Y, Ike (2003) The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. Neuron 37:449-61 [PubMed]

Noonan L, Doiron B, Laing C, Longtin A, Turner RW (2003) A dynamic dendritic refractory period regulates burst discharge in the electrosensory lobe of weakly electric fish. J Neurosci 23:1524-34 [PubMed]

Oswald AM, Chacron MJ, Doiron B, Bastian J, Maler L (2004) Parallel processing of sensory input by bursts and isolated spikes. J Neurosci 24:4351-62 [PubMed]

Pinsky PF, Rinzel J (1994) Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1:39-60 [Journal] [PubMed]

   CA3 pyramidal cell: rhythmogenesis in a reduced Traub model (Pinsky, Rinzel 1994) [Model]

Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Prinz AA, Bucher D, Marder E (2004) Similar network activity from disparate circuit parameters. Nat Neurosci 7:1345-52 [PubMed]

   Lobster STG pyloric network model with calcium sensor (Gunay & Prinz 2010) (Prinz et al. 2004) [Model]

Rashid AJ, Dunn RJ, Turner RW (2001) A prominent soma-dendritic distribution of Kv3.3 K+ channels in electrosensory and cerebellar neurons. J Comp Neurol 441:234-47 [PubMed]

Rashid AJ, Morales E, Turner RW, Dunn RJ (2001) The contribution of dendritic Kv3 K+ channels to burst threshold in a sensory neuron. J Neurosci 21:125-35 [PubMed]

Reyes AD, Fetz EE (1993) Effects of transient depolarizing potentials on the firing rate of cat neocortical neurons. J Neurophysiol 69:1673-83 [Journal]

Rinzel J, Ermentrout B (1998) Analysis of neural excitability and oscillations. Methods In Neuronal Modeling 2nd Edition, Segev I, Koch C, ed. pp.251

Rudy B, Seeburg P (1999) Molecular and Functional Diversity of Ion Channels and Receptors. Anns NY Acad Sci

Schiller J, Major G, Koester HJ, Schiller Y (2000) NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature 404:285-9 [PubMed]

Schwindt P, Crill W (1999) Mechanisms underlying burst and regular spiking evoked by dendritic depolarization in layer 5 cortical pyramidal neurons. J Neurophysiol 81:1341-54 [Journal] [PubMed]

Shao LR, Halvorsrud R, Borg-Graham L, Storm JF (1999) The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells. J Physiol 521 Pt 1:135-46 [PubMed]

Spruston N, Schiller Y, Stuart G, Sakmann B (1995) Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science 268:297-300 [PubMed]

Strogatz SH (1994) Nonlinear Dynamics And Chaos With Applications To Physics, Biology, Chemistry, And Engineering

Stuart G, Hausser M (1994) Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron 13:703-12 [PubMed]

Stuart G, Spruston N, Sakmann B, Hausser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20:125-31 [PubMed]

Tank DW, Sugimori M, Connor JA, Llinas RR (1988) Spatially resolved calcium dynamics of mammalian Purkinje cells in cerebellar slice. Science 242:773-7 [PubMed]

Tateno T, Harsch A, Robinson HP (2004) Threshold firing frequency-current relationships of neurons in rat somatosensory cortex: type 1 and type 2 dynamics. J Neurophysiol 92:2283-94 [PubMed]

Turner RW, Maler L, Deerinck T, Levinson SR, Ellisman MH (1994) TTX-sensitive dendritic sodium channels underlie oscillatory discharge in a vertebrate sensory neuron. J Neurosci 14:6453-71 [PubMed]

Turner RW, Meyers DE, Richardson TL, Barker JL (1991) The site for initiation of action potential discharge over the somatodendritic axis of rat hippocampal CA1 pyramidal neurons. J Neurosci 11:2270-80 [PubMed]

Van Goor F, LeBeau AP, Krsmanovic LZ, Sherman A, Catt KJ, Stojilkovic SS (2000) Amplitude-dependent spike-broadening and enhanced Ca(2+) signaling in GnRH-secreting neurons. Biophys J 79:1310-23 [PubMed]

Wang XJ (1999) Fast burst firing and short-term synaptic plasticity: a model of neocortical chattering neurons. Neuroscience 89:347-62 [PubMed]

Williams SR, Stuart GJ (2000) Backpropagation of physiological spike trains in neocortical pyramidal neurons: implications for temporal coding in dendrites. J Neurosci 20:8238-46 [PubMed]

Winfree AT (1980) The geometry of biological time.

Chacron MJ, Lindner B, Longtin A (2007) Threshold fatigue and information transfer. J Comput Neurosci 23:301-11 [Journal] [PubMed]

Doiron B, Oswald AM, Maler L (2007) Interval Coding. II. Dendrite-Dependent Mechanisms. J Neurophysiol 97:2744-57 [Journal] [PubMed]

Ellis LD, Krahe R, Bourque CW, Dunn RJ, Chacron MJ (2007) Muscarinic receptors control frequency tuning through the downregulation of an A-type potassium current. J Neurophysiol : [PubMed]

Fernandez FR, Engbers JD, Turner RW (2007) Firing dynamics of cerebellar purkinje cells. J Neurophysiol 98:278-94 [PubMed]

Gabbiani F, Cox SJ (2010) Mathematics for Neuroscientists :1-486 [Journal]

   Mathematics for Neuroscientists (Gabbiani and Cox 2010) [Model]

Mehaffey WH, Fernandez FR, Maler L, Turner RW (2007) Regulation of burst dynamics improves differential encoding of stimulus frequency by spike train segregation. J Neurophysiol 98:939-51 [PubMed]

(59 refs)