A model of canine I:(to1) (the Ca(2+)-independent transient outward current) is formulated as the combination of Kv4.3 and Kv1.4
currents and is incorporated into an existing canine ventricular myocyte model. Simulations demonstrate strong
coupling between L-type Ca(2+) current and I:(Kv4.3) and predict a bimodal relationship between I:(Kv4.3)
density and APD whereby perturbations in I:(Kv4.3) density may produce either prolongation or shortening of APD,
depending on baseline I:(to1) current level.
The model files were submitted by:
Dr. Sheng-Nan Wu, Dr. Ruey J. Sung, Ya-Jean Wang and Jiun-Shian Wu
Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL (2000) Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ Res 87:1026-33 [PubMed]