Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Stochastic Ih and Na-channels in pyramidal neuron dendrites (Kole et al 2006)
Download zip file
Help downloading and running models
Versions on GitHub
The hyperpolarization-activated cation current (Ih) plays an important role in regulating neuronal excitability, yet its native single-channel properties in the brain are essentially unknown. Here we use variance-mean analysis to study the properties of single Ih channels in the apical dendrites of cortical layer 5 pyramidal neurons in vitro. ... In contrast to the uniformly distributed single-channel conductance, Ih channel number increases exponentially with distance, reaching densities as high as approximately 550 channels/microm2 at distal dendritic sites. These high channel densities generate significant membrane voltage noise. By incorporating a stochastic model of Ih single-channel gating into a morphologically realistic model of a layer 5 neuron, we show that this channel noise is higher in distal dendritic compartments and increased threefold with a 10-fold increased single-channel conductance (6.8 pS) but constant Ih current density. ... These data suggest that, in the face of high current densities, the small single-channel conductance of Ih is critical for maintaining the fidelity of action potential output. See paper for more and details.
Kole MH, Hallermann S, Stuart GJ (2006) Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Neocortex V1 L6 pyramidal corticothalamic cell;
Ion Channel Kinetics;
Hallermann, Stefan [hallermann at medizin.uni-leipzig.de];
for information about:
Neocortex V1 L6 pyramidal corticothalamic cell
File not selected
<- Select file from this column.
Load Model Views
Short run simulation
Loading data, please wait...