Reciprocal regulation of rod and cone synapse by NO (Kourennyi et al 2004)

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Accession:64216
We constructed models of rod and cone photoreceptors using NEURON software to predict how changes in Ca channels would affect the light response in these cells and in postsynaptic horizontal cells.
Reference:
1 . Kourennyi DE, Liu XD, Hart J, Mahmud F, Baldridge WH, Barnes S (2004) Reciprocal modulation of calcium dynamics at rod and cone photoreceptor synapses by nitric oxide. J Neurophysiol 92:477-83 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Retina photoreceptor cone GLU cell;
Channel(s): I Chloride; I K; I h; I K,Ca; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): NO;
Simulation Environment: NEURON;
Model Concept(s): Calcium dynamics; Vision;
Implementer(s): Kourennyi, Dmitri E [dek at case.edu]; Liu, Xiaodong [xliu22 at jhmi.edu];
Search NeuronDB for information about:  Retina photoreceptor cone GLU cell; I Chloride; I K; I h; I K,Ca; I Calcium; I Potassium; NO;
: Rod Photoreceptor Kv channel

NEURON 
{
	SUFFIX Kv
	
	USEION Kv WRITE iKv VALENCE 1
	
	
        RANGE gKv,gKvbar, eKv
	
	
	
	

}

UNITS
{
	(mA) = (milliamp)
	(mV) = (millivolt)
	(mS) = (millimho)
	
}

PARAMETER
{
        : potassium rectifier
        gKvbar = 2.0 (mS/cm2) <0,1e9>
        eKv = -80 (mV)
       
        

}

STATE
{
	mKv
	hKv
	
}

ASSIGNED
{
	v (mV)
	
	iKv (mA/cm2)
              
          : potussium rectifier, K
	infmKv
	taumKv  (ms)
	infhKv
	tauhKv  (ms)
           
     
	gKv (mho/cm2)
	
}

INITIAL
{
	rate(v)
	mKv = infmKv
	hKv  = infhKv
}




BREAKPOINT
{
	SOLVE states METHOD cnexp
	gKv = (0.001)*gKvbar*mKv*mKv*mKv *hKv
	iKv = gKv*(v - eKv)
}

DERIVATIVE states
{
	rate(v)
	mKv' = (infmKv - mKv)/taumKv
	hKv' =  (infhKv - hKv )/tauhKv

}


UNITSOFF

FUNCTION alphamKv(v(mV)) (/ms)
{ 
	alphamKv = (0.001)*5*(100-v)/( exp( (100-v)/42) -1 )
	:alter from orginal settings where it is in the unit of 1/s
}

FUNCTION  betamKv (v(mV)) (/ms)
{
	
	betamKv = (0.001)*9*exp (- (v-20) /40 )
}


FUNCTION alphahKv (v(mV)) (/ms)
{
	alphahKv = (0.001)*0.15 *exp (-v/22)
}

FUNCTION betahKv (v(mV)) (/ms)
{ 
	betahKv = (0.001)*0.4125/( exp ( ( 10-v)/7 ) +1 )

}

UNITSON

PROCEDURE rate(v (mV))
{
        LOCAL a, b

	
	a = alphamKv(v)
	b = betamKv(v)
	taumKv = 1/(a + b)
	infmKv = a/(a + b)
	
	a = alphahKv(v)
	b = betahKv(v)
	tauhKv = 1/(a + b)
	infhKv = a/(a + b)
	

}


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