CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)

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Accession:71312
The model shows how different input patterns (irregular & asynchronous, irregular & synchronous, regular & asynchronous, regular & synchronous) affect the neuron's output rate when 1000 synapses are distributed in the proximal apical dendritic tree of a hippocampus CA1 pyramidal neuron.
References:
1 . Li X, Ascoli GA (2006) Computational simulation of the input-output relationship in hippocampal pyramidal cells J of Comput Neurosci 21(2):191-209 [PubMed]
2 . Li X, Ascoli GA (2008) Effects of synaptic synchrony on the neuronal input-output relationship. Neural Comput 20:1717-31 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Synaptic Integration;
Implementer(s): Li, Xiaoshen [xsli2 at yahoo.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I A; I K; I h;
/
xiaoshenli
readme.txt
distr.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
c20466.hoc
createNewSyn.hoc
createNewSyn2.hoc
exec.hoc
fig4A.hoc
fixnseg.hoc *
ModelTypeC.hoc
ModelTypeI.hoc
mosinit.hoc
NregNsyn.hoc
Nregsyn.hoc
regNsyn.hoc *
                            
/****************************************************************
Used in CA1Models/MiglioreNew2/
cleaned up from Model.hoc. Has been tested to be correct
Jan.9 2005
Load a cell's morphology file and then load Type I biophysical model
****************************************************************/
/*--------------------playing random seed----------------*/
MODELTYPE = 0
use_mcell_ran4(1)
lowindex = 1001
mcell_ran4_init(lowindex)
highindex = 1
tstop = 250

print "---------------------------Type I Model-----------------------------"

//flag for wether or not to use NMDA-R: 0 for without NMDA-R, 1 for with NMDA-R
//this flag will be used in subsequent hoc files: NregNsyn.hoc, Nregsyn.hoc etc
NMDAFLAG = 0

if (NMDAFLAG == 0) { //only AMPA-R
    wtAmpa = 1
    wtNmda = 0
} else { //NMDAFLAG = 1, with both AMPA-R, NMDA-R
    wtAmpa = 0.8
    wtNmda = 0.2
}

xopen("./c20466.hoc")             // geometry file

soma area(0.5) //make sure diam reflects 3d points

//USER5MAX, APIDENDMAX, BASDENDMAX are set in cell's hoc file
TOTALDEND = USER5MAX + APIDENDMAX + BASDENDMAX + 3 //"3": counting start at 0
objref dend[TOTALDEND]

/****************************************************************************
Grouping dendritic sections together in an array dend, later for being used to
randomly put synapses on the proximal apical, distal apical and basal dendrite
*****************************************************************************/
index = 0

forsec "dendrite" { //this will includes both dendrites and apical-dendrites
    dend[index] = new SectionRef()
    index += 1
}

forsec "user5" {
    dend[index] = new SectionRef()
    index += 1
} //now index = USER5MAX + 1

//quadratic function fitting result A and B are set in cell's hoc file
A = A0
B = B0

//synapse rise and decay time constants
TAU1=0.2 //ms
TAU2=10  //ms

dist=1
rel=0.1


Rm = 28000    //unit: Ohm-cm^2
RmDend = Rm/1
RmSoma = Rm
RmAx = Rm

Cm    = 1
CmSoma= Cm
CmAx  = Cm
CmDend = Cm*1

RaAll= 50  //unit: Ohm-cm
RaSoma=50  
RaAx = 50

Vrest = -65
gna =  .02  //increasing Na+ channel density instead of decreasing KMULT from 0.025 to 0.015
AXONM = 2
gkdr = 0.01
celsius = 35.0  
KMULT =  0.025  //was 0.025
KMULTP = 0.025  //was 0.025
gcan=0.0//005
gcal=0.0//005
gcat=0.0//005
ghd=0.00005
nash=0

forsec "axon" {
                insert pas e_pas=Vrest g_pas = 1/RmAx Ra=RaAx cm=CmAx
}

forsec "soma" {
                insert pas e_pas=Vrest g_pas = 1/RmSoma Ra=RaSoma cm=CmSoma
}

forsec "dendrite" {  //acidentally includes both dendrte and apical_dendrite, i.e. basal & oblique api.
		insert pas e_pas=Vrest g_pas = 1/RmDend Ra=RaAll cm=CmDend
}

forsec "user5" {
		insert pas e_pas=Vrest g_pas = 1/RmDend Ra=RaAll  cm=CmDend
}


access soma
freq=50
load_file("fixnseg.hoc")
geom_nseg()

tot=0
forall {tot=tot+nseg}
distance()
maxdist=0
forsec "user5" for(x) {if (distance(x)>maxdist) {maxdist=distance(x)}}
printf ("total # of segments (%g hz): %g  \t max path distance:  %g\n", freq, tot, maxdist)

/****************************************************************************************
The following two lines of declaration are to match up ModelTypeC.hoc mapping bifurcation.
They are not used in ModelTypeI.hoc & ModelPassive.hoc
****************************************************************************************/
objref  outfile, sref, blist[USER5MAX+1],   aplist
strdef dend2, trunk


forsec "axon" {   
                insert nax gbar_nax=gna * AXONM	sh_nax=nash
                insert kdr gkdrbar_kdr=gkdr
                //insert pas e_pas=Vrest g_pas = 1/RmAx Ra=RaAx cm=CmAx
                insert kap gkabar_kap = KMULTP*0.2
}

forsec "soma" {   
		insert hd ghdbar_hd=ghd	vhalfl_hd=-73
                insert na3 ar_na3=1 sh_na3=nash gbar_na3=gna
                insert kdr gkdrbar_kdr=gkdr
                insert kap gkabar_kap = KMULTP
                //insert pas e_pas=Vrest g_pas = 1/RmSoma Ra=RaSoma cm=CmSoma
}

/*---------------------setting up apical oblique dendrite channel kinetics--------*/
for (i=0; i<= APIDENDMAX; i += 1) {
        access apical_dendrite[i] {
	insert ds
                if (diam>0.35) {factor=1} else {factor=1}
                insert hd ghdbar_hd=ghd
                insert na3 ar_na3=1 gbar_na3=gna*factor sh_na3=nash
                insert kdr gkdrbar_kdr=gkdr*factor
                insert kap gkabar_kap=0
                insert kad gkabar_kad=0

                for (x) if (x>0 && x<1) { xdist = distance(x)
                        ghdbar_hd(x) = factor*ghd*(1+3*xdist/100)
                                if (xdist > 100){
                                        vhalfl_hd=-81
                                        gkabar_kad(x) = factor*KMULT*(1+xdist/100)
                                        } else {
                                        vhalfl_hd=-73
                                        gkabar_kap(x) = factor*KMULTP*(1+xdist/100)
                                        }
                }
        }
}


/*---------------------setting up basal dendrite channel kinetics--------*/
for (i=0; i <= BASDENDMAX; i += 1) { 
	access dendrite[i] { 
		if (diam>0.35) {factor=1} else {factor=1}
		insert hd ghdbar_hd=ghd
                insert na3 ar_na3=1 gbar_na3=gna*factor sh_na3=nash
                insert kdr gkdrbar_kdr=gkdr*factor
		insert kap gkabar_kap=0
		insert kad gkabar_kad=0

		for (x) if (x>0 && x<1) { xdist = distance(x)
                	ghdbar_hd(x) = factor*ghd*(1+3*xdist/100)
                		if (xdist > 100){
					vhalfl_hd=-81
                        		gkabar_kad(x) = factor*KMULT*(1+xdist/100)
                			} else {
					vhalfl_hd=-73
                        		gkabar_kap(x) = factor*KMULTP*(1+xdist/100)
               				}
		}
	}
}

/*----------------------------setting up main trunk channel kinetics-------------*/
forsec "user5" {   // the main trunk
	insert ds
//	if (diam>0.5) {
		insert hd ghdbar_hd=ghd
                insert na3 ar_na3=1 gbar_na3=gna sh_na3=nash
                insert kdr gkdrbar_kdr=gkdr
		insert kap gkabar_kap=0
		insert kad gkabar_kad=0

		for (x) if (x>0 && x<1) { xdist = distance(x)
                	ghdbar_hd(x) = ghd*(1+3*xdist/100)
                		if (xdist > 100){
					vhalfl_hd=-81
                        		gkabar_kad(x) = KMULT*(1+xdist/100)
                			} else {
					vhalfl_hd=-73
                        		gkabar_kap(x) = KMULTP*(1+xdist/100)
               				}
		}
//	}
}

//correct the default section name
access soma

objref pw
pw = new PWManager()
pw.landscape(1)


proc init() {
	t=0
        forall {
        v=Vrest
        if (ismembrane("nax") || ismembrane("na3")) {ena=55}
        //if (ismembrane("na3")) {ar_na3 = 0.6}
	
        if (ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {ek=-90}
        if (ismembrane("hd") ) {ehd_hd=-30}
	}
	finitialize(Vrest)
        fcurrent()

        forall {
	for (x) {
	if (ismembrane("na3")||ismembrane("nax")){e_pas(x)=v(x)+(ina(x)+ik(x))/g_pas(x)}
	if (ismembrane("hd")) {e_pas(x)=e_pas(x)+i_hd(x)/g_pas(x)}
		}
	}
	cvode.re_init()
	cvode.event(tstop)
	access soma
//	g.begin()
}


proc advance() {
	fadvance()
//	g.plot(t)
//	g.flush()
//	p.flush()
//	doNotify()
}


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