Activity dependent changes in motoneurones (Dai Y et al 2002, Gardiner et al 2002)

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Accession:71317
These two papers review various experimental papers and examine the effects of activity on motoneurons in a similar 5 compartment model with 10 active conductances. Included are slow (S) and fast (F) type and fast fatigue resistant (FR) and fast fatigable (FF) models corresponding to the types of motoneurons. See papers for more and details.
References:
1 . Dai Y, Jones KE, Fedirchuk B, McCrea DA, Jordan LM (2002) A modelling study of locomotion-induced hyperpolarization of voltage threshold in cat lumbar motoneurones. J Physiol 544:521-36 [PubMed]
2 . Gardiner P, Dai Y, Heckman CJ (2006) Effects of exercise training on alpha-motoneurons. J Appl Physiol (1985) 101:1228-36 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Simplified Models; Tutorial/Teaching;
Implementer(s): Dai, Yue [ydai at scrc.umanitoba.ca];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I Potassium;
 
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