Hippocampus temporo-septal engram shift model (Lytton 1999)

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Accession:7400
Temporo-septal engram shift model of hippocampal memory. The model posits that memories gradually move along the hippocampus from a temporal encoding site to ever more septal sites from which they are recalled. We propose that the sense of time is encoded by the location of the engram along the temporo-septal axis.
Reference:
1 . Lytton WW, Lipton P (1999) Can the hippocampus tell time? The temporo-septal engram shift model. Neuroreport 10:2301-6 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s):
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Pattern Recognition; Temporal Pattern Generation; Spatio-temporal Activity Patterns; Simplified Models;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu];
Search NeuronDB for information about:  GabaA; AMPA; I Na,t; I K;
Lytton WW; Lipton P. Can the hippocampus tell time?: The
temporo-septal engram shift model.
Neuroreport, 10:2301--2306, 1999.

This example produces Fig. 1 p 2302 as shown in fig1.gif.  The
simulation takes several minutes and the progress is indicated in the
console window by printing the time approximately every 300 ms.  At 5000
ms, the figure will be displayed in two graph windows.  The raster plot
will probably be hidden underneath the plot of Net[20].soma.v(0.5)
NB: the first cycle of stimulation produces an initialization artifact
(bursting in all cells) that is not shown in the original figure. 

For questions about the model contact Bill Lytton at
billl@neurosim.downstate.edu

Michael Hines made some non-substantive changes to vecst.mod (derived
from vecst.mod.orig) to allow running the model under mswin and on the
mac.  The most significant being the incorporation of a free version of
srand/drand from
http://www.mit.edu/afs/athena/activity/c/cgs/src/math/drand48/
 Under mswin, this model can only be run using NEURON version 5.2
2002/02/28 or later since it makes use of calls to sprintf and
hoc_obj_file_arg which were not exported by earlier versions.  On a MAC
you may need to increase the memory size for NEURON to 24MB. 


Lytton WW, Lipton P (1999) Can the hippocampus tell time? The temporo-septal engram shift model. Neuroreport 10:2301-6[PubMed]

References and models cited by this paper

References and models that cite this paper

Alvarez P, Squire LR (1994) Memory consolidation and the medial temporal lobe: a simple network model. Proc Natl Acad Sci U S A 91:7041-5 [PubMed]

Anderson P, Bliss TV, Skrede KK (1971) Lamellar organization of hippocampal pathways. Exp Brain Res 13:222-38 [PubMed]

Bliss TV, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232:331-56 [PubMed]

Cavazos JE, Golarai G, Sutula TP (1992) Septotemporal variation of the supragranular projection of the mossy fiber pathway in the dentate gyrus of normal and kindled rats. Hippocampus 2:363-72 [PubMed]

Claiborne BJ, Amaral DG, Cowan WM (1986) A light and electron microscopic analysis of the mossy fibers of the rat dentate gyrus. J Comp Neurol 246:435-58 [PubMed]

Damasio AR (1990) Category-related recognition defects as a clue to the neural substrates of knowledge. Trends Neurosci 13:95-8 [PubMed]

Davis BD (1985) Sleep and the maintenance of memory. Perspect Biol Med 28:457-64 [PubMed]

Giuditta A, Ambrosini MV, Montagnese P, Mandile P, Cotugno M, Grassi Zucconi G, Vescia S (1995) The sequential hypothesis of the function of sleep. Behav Brain Res 69:157-66 [PubMed]

Grunwald T, Lehnertz K, Heinze HJ, Helmstaedter C, Elger CE (1998) Verbal novelty detection within the human hippocampus proper. Proc Natl Acad Sci U S A 95:3193-7 [PubMed]

Hennevin E, Hars B, Maho C, Bloch V (1995) Processing of learned information in paradoxical sleep: relevance for memory. Behav Brain Res 69:125-35 [PubMed]

Holscher C, Anwyl R, Rowan MJ (1997) Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can Be depotentiated by stimulation on the negative phase in area CA1 in vivo. J Neurosci 17:6470-7 [PubMed]

Hopfield JJ (1982) Neural networks and physical systems with emergent collective computational abilities. Proc Natl Acad Sci U S A 79:2554-8 [PubMed]

Lepage M, Habib R, Tulving E (1998) Hippocampal PET activations of memory encoding and retrieval: the HIPER model. Hippocampus 8:313-22 [PubMed]

Loy R, Koziell DA, Lindsey JD, Moore RY (1980) Noradrenergic innervation of the adult rat hippocampal formation. J Comp Neurol 189:699-710 [PubMed]

Lytton WW (1998) Adapting a feedforward heteroassociative network to Hodgkin-Huxley dynamics. J Comput Neurosci 5:353-64 [Journal] [PubMed]

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Meador-Woodruff JH, Grandy DK, Van Tol HH, Damask SP, Little KY, Civelli O, Watson SJ (1994) Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology 10:239-48 [PubMed]

Melges FT, Freeman AM (1977) Temporal disorganization and inner-outer confusion in acute mental illness. Am J Psychiatry 134:874-7 [PubMed]

Moser MB, Moser EI (1998) Distributed encoding and retrieval of spatial memory in the hippocampus. J Neurosci 18:7535-42 [PubMed]

Nyberg L, McIntosh AR, Cabeza R, Habib R, Houle S, Tulving E (1996) General and specific brain regions involved in encoding and retrieval of events: what, where, and when. Proc Natl Acad Sci U S A 93:11280-5 [PubMed]

O'Reilly RC, McClelland JL (1994) Hippocampal conjunctive encoding, storage, and recall: avoiding a trade-off. Hippocampus 4:661-82 [PubMed]

Ott BR, Saver JL (1993) Unilateral amnesic stroke. Six new cases and a review of the literature. Stroke 24:1033-42 [PubMed]

Poucet B, Thinus-Blanc C, Muller RU (1994) Place cells in the ventral hippocampus of rats. Neuroreport 5:2045-8 [PubMed]

Shen B, McNaughton BL (1996) Modeling the spontaneous reactivation of experience-specific hippocampal cell assembles during sleep. Hippocampus 6:685-92 [PubMed]

Sigala S, Missale C, Spano P (1997) Opposite effects of dopamine D2 and D3 receptors on learning and memory in the rat. Eur J Pharmacol 336:107-12 [PubMed]

Slomianka L, Geneser FA (1993) Distribution of acetylcholinesterase in the hippocampal region of the mouse. III. The area dentata. J Comp Neurol 331:225-35 [PubMed]

Squire LR (1982) Comparisons between forms of amnesia: some deficits are unique to Korsakoff's syndrome. J Exp Psychol Learn Mem Cogn 8:560-71 [PubMed]

Squire LR, Spanis CW (1984) Long gradient of retrograde amnesia in mice: continuity with the findings in humans. Behav Neurosci 98:345-8 [PubMed]

Teyler TJ, DiScenna P (1986) The hippocampal memory indexing theory. Behav Neurosci 100:147-54 [PubMed]

Treves A, Rolls ET (1994) Computational analysis of the role of the hippocampus in memory. Hippocampus 4:374-91 [PubMed]

Trimble MR (1991) Interictal psychoses of epilepsy. Adv Neurol 55:143-52 [PubMed]

Tulving E, Kapur S, Craik FI, Moscovitch M, Houle S (1994) Hemispheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings. Proc Natl Acad Sci U S A 91:2016-20 [PubMed]

Tulving E, Markowitsch HJ (1998) Episodic and declarative memory: role of the hippocampus. Hippocampus 8:198-204 [PubMed]

Verney C, Baulac M, Berger B, Alvarez C, Vigny A, Helle KB (1985) Morphological evidence for a dopaminergic terminal field in the hippocampal formation of young and adult rat. Neuroscience 14:1039-52 [PubMed]

Wilson MA, McNaughton BL (1994) Reactivation of hippocampal ensemble memories during sleep. Science 265:676-9 [PubMed]

Hines ML, Carnevale NT (2001) NEURON: a tool for neuroscientists. Neuroscientist 7:123-35 [Journal] [PubMed]

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Hines ML, Carnevale NT (2003) Personal Communication of NEURON bibliography

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