Cerebellar purkinje cell: interacting Kv3 and Na currents influence firing (Akemann, Knopfel 2006)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:80769
Purkinje neurons spontaneously generate action potentials in the absence of synaptic drive and thereby exert a tonic, yet plastic, input to their target cells in the deep cerebellar nuclei. Purkinje neurons express two ionic currents with biophysical properties that are specialized for high-frequency firing: resurgent sodium currents and potassium currents mediated by Kv3.3. Numerical simulations indicated that Kv3.3 increases the spontaneous firing rate via cooperation with resurgent sodium currents. We conclude that the rate of spontaneous action potential firing of Purkinje neurons is controlled by the interaction of Kv3.3 potassium currents and resurgent sodium currents. See paper for more and details.
Reference:
1 . Akemann W, Knöpfel T (2006) Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. J Neurosci 26:4602-12 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): I Na,t; I A; I K; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.1 KCNA1; Kv4.3 KCND3; Kv3.3 KCNC3; HCN1;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Oscillations; Action Potentials; Calcium dynamics;
Implementer(s): Akemann, Walther [akemann at brain.riken.jp];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,t; I A; I K; I h; I K,Ca; I Calcium;
celsius = 24  // (degC)

create soma
access soma

soma.nseg = 1
soma.L = 20		// (um)       
soma.diam = 20	// (um)
soma.cm = 1       // (uF/cm2)

insert Narsg
insert Na
insert Kv1
insert Kv4
insert Kbin
insert CaBK
insert Caint
insert CaP
insert Ih
insert leak

soma.ena = 60	// (mV)
soma.ek = -88	// (mV)
soma.eh_Ih = -30
soma.e_leak = -61
soma.cao = 2   // (mM)
     
soma.gbar_Narsg = 0.016     // (mho/cm2)
soma.gbar_Na = 0.014
soma.gbar_Kv1 = 0.011
soma.gbar_Kv4 = 0.0039
soma.gbar_Kbin = 0.0016
soma.gkbar_CaBK = 0.014
soma.pcabar_CaP = 0.00006
soma.ghbar_Ih = 0.0002
soma.gbar_leak = 9e-5

Loading data, please wait...