Fluctuating synaptic conductances recreate in-vivo-like activity (Destexhe et al 2001)

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Accession:8115
This model (and experiments) reported in Destexhe, Rudolh, Fellous, and Sejnowski (2001) support the hypothesis that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically. Some of these cortical neuron characteristics of fluctuating synaptic origin are a depolarized membrane potential, the presence of high-amplitude membrane potential fluctuations, a low input resistance and irregular spontaneous firing activity. In addition, the point-conductance model could simulate the enhancement of responsiveness due to background activity. For more information please contact Alain Destexhe. email: Destexhe@iaf.cnrs-gif.fr
Reference:
1 . Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ (2001) Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience 107:13-24 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell;
Channel(s): I Na,t; I K; I M;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Simplified Models; Synaptic noise;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; GabaA; AMPA; I Na,t; I K; I M;
    NEURON DEMO FOR SIMULATING FLUCTUATING SYNAPTIC CONDUCTANCES

                          Alain Destexhe

            CNRS, UNIC (Bat-33), Avenue de la Terrasse,
                 91198 Gif-sur-Yvette, France

                     Destexhe@iaf.cnrs-gif.fr
                    http://cns.iaf.cnrs-gif.fr


This package is running with the NEURON simulation program written by Michael
Hines and available on internet at:
  http://www.neuron.yale.edu

The package contains mechanisms (.mod files) and programs (.oc files) needed 
to simulate synaptic background activity similar to in vivo measurements
using a model of fluctuating synaptic conductances.  This "point-conductance"
model recreates in-vivo-like membrane parameters, such as the depolarized
membrane potential, the low input resistance and high-amplitude membrane
potential fluctuations.  All details are given in the following paper:

Destexhe A, Rudolph M, Fellous JM and Sejnowski TJ. Fluctuating synaptic 
conductances recreate in-vivo-like activity in neocortical neurons.
Neuroscience 107: 13-24, 2001.

(see electronic copy at  http://cns.iaf.cnrs-gif.fr)



  PROGRAMS
  ========

demo_gfluct.oc : illustrates the point-conductance model


  MECHANISMS
  ==========

 Gfluct.mod		: fluctuating synaptic conductances
 INa_traub_shifted.mod  : fast sodium current
 IKd_traub.mod          : delayed-rectifier potassium current
 IM.mod 		: slow voltage-dependent potassium current (IM)


  HOW TO RUN
  ==========

To compile the demo, NEURON and INTERVIEWS must be installed and working on
the machine you are using.  Just type "nrnivmodl" to compile the mechanisms
given in the mod files.

Then, execute the main demo program by typing:

nrngui demo_gfluct.oc

(for older NEURON versions than 4.3.1
special demo_gfluct.oc -
)
Once the menu and graphics interface has appeared, click on "Init and Run" 
to start the simulation...

For more information about how to get NEURON and how to install it, please
refer to the following sites:
  http://www.neuron.yale.edu
  http://www.neuro.duke.edu



For further information, please contact:

Alain Destexhe

CNRS, UNIC (Bat-33), 
Avenue de la Terrasse,
91198 Gif-sur-Yvette, 
France

email: Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr

20110411 changed solve method to cnexp in IM.mod as per
"Integration methods for SOLVE statements" topic in the NEURON forum
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
-ModelDB Administrator

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