Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995)

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Accession:8210
This model reproduces figure 3A from the paper Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995). Please see the paper for detail whose full text is available at http://www.cnl.salk.edu/~zach/methods.html Email Zach Mainen for questions: mainen@cshl.org
Reference:
1 . Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Myelinated neuron;
Channel(s): I Na,p; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Axonal Action Potentials;
Implementer(s): Mainen, Zach [Mainen at cshl.edu];
Search NeuronDB for information about:  I Na,p; I K;
This model is associated with the paper:

A model of spike initiation in neocortical pyramidal neurons 
Z. F. Mainen, J. Joerges, J. R. Huguenard and T. J. Sejnowski 
Neuron 15, 1427-1439 (1995)


Please see 

http://www.cnl.salk.edu/~zach/methods.html

where a full text (postscript format) copy of the paper
and copies of the model for early versions of neuron is available.

This model contains compartmental models of a reconstructed neocortical
neuron with active dendritic currents using NEURON. This paper examines
the paradox that although spikes can back-propagate from the soma into dendrites 
with spike amplitudes maintained in dendrites by voltage-gated channels it rarely
occurs that spikes are initiated in dendrites in these cells. The model suggests
that dendritic channel inactivation and source-load considerations are contributing
factors. See the paper for more details.

This package is written in the NEURON simulation program written by Michael
Hines and available on internet at:
http://www.neuron.yale.edu/


  HOW TO RUN (under NEURON version 5 and higher)
  =========================================

To compile the demo, NEURON and INTERVIEWS must be installed and working on
the machine you are using.

When the spikeinit.zip file is unzipped it creates a spikeinit directory which
contains the hoc and mod NEURON program files.  Change directory to spikeinit.

under UNIX:
===========

Just type "nrnivmodl" to compile the mechanisms
given in the mod files in the  directory.

Execute the first figure demo program by typing:

nrngui demo.hoc

continue below under back to any platform:

under MS WINDOWS (PC):
======================

Press Start button (lower left corner) and then press Programs and then
NEURON and then mknrndll.  Change directory to where the zip file was
unzipped and enter the directory that came with the zip file (spikeinit).
Press the nrnmech.dll button.

You can start the simulation by a double click on
demo.hoc
in windows explorer.

The simulation produces fig 3 from the paper.

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39[PubMed]

References and models cited by this paper

References and models that cite this paper

Alzheimer C, Schwindt PC, Crill WE (1993) Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex. J Neurosci 13:660-73 [PubMed]

Amitai Y, Friedman A, Connors BW, Gutnick MJ (1993) Regenerative activity in apical dendrites of pyramidal cells in neocortex. Cereb Cortex 3:26-38 [PubMed]

Angelides KJ, Elmer LW, Loftus D, Elson E (1988) Distribution and lateral mobility of voltage-dependent sodium channels in neurons. J Cell Biol 106:1911-25 [PubMed]

Bedlack RS, Wei MD, Fox SH, Gross E, Loew LM (1994) Distinct electric potentials in soma and neurite membranes. Neuron 13:1187-93 [PubMed]

Belluzzi O, Sacchi O (1986) A quantitative description of the sodium current in the rat sympathetic neurone. J Physiol 380:275-91 [PubMed]

Bernander O, Douglas RJ, Martin KA, Koch C (1991) Synaptic background activity influences spatiotemporal integration in single pyramidal cells. Proc Natl Acad Sci U S A 88:11569-73 [PubMed]

Black JA, Kocsis JD, Waxman SG (1990) Ion channel organization of the myelinated fiber. Trends Neurosci 13:48-54 [PubMed]

Chiu SY, Schwarz W (1987) Sodium and potassium currents in acutely demyelinated internodes of rabbit sciatic nerves. J Physiol 391:631-49 [PubMed]

Cooley JW, Dodge FA (1966) Digital computer solutions for excitation and propagation of the nerve impulse. Biophys J 6:583-99 [PubMed]

COOMBS JS, CURTIS DR, ECCLES JC (1957) The generation of impulses in motoneurones. J Physiol 139:232-49 [PubMed]

Cowan RL, Wilson CJ (1994) Spontaneous firing patterns and axonal projections of single corticostriatal neurons in the rat medial agranular cortex. J Neurophysiol 71:17-32 [Journal] [PubMed]

Cummins TR, Xia Y, Haddad GG (1994) Functional properties of rat and human neocortical voltage-sensitive sodium currents. J Neurophysiol 71:1052-64 [Journal] [PubMed]

De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. J Neurophysiol 71:375-400 [Journal] [PubMed]

   Cerebellar purkinje cell (De Schutter and Bower 1994) [Model]

Deschaenes M, Landry P (1980) Axonal branch diameter and spacing of nodes in the terminal arborization of identified thalamic and cortical neurons. Brain Res 191:538-44 [PubMed]

Dodge FA, Cooley JW (1973) Action Potential of the Motorneuron. IBM J Res Dev 17:219-29

   Spinal Motor Neuron (Dodge, Cooley 1973) [Model]

Erecinska M, Silver IA (1989) ATP and brain function. J Cereb Blood Flow Metab 9:2-19 [PubMed]

Farinas I, DeFelipe J (1991) Patterns of synaptic input on corticocortical and corticothalamic cells in the cat visual cortex. II. The axon initial segment. J Comp Neurol 304:70-7 [PubMed]

Frank K, Fuortes MGF (1957) Presynaptic and postsynaptic inhibition of monosynaptic reflexes. Fed Proc 16:39-40

Gogan P, Gueritaud JP, Tyc-Dumont S (1983) Comparison of antidromic and orthodromic action potentials of identified motor axons in the cat's brain stem. J Physiol 335:205-20 [PubMed]

Graham B, Redman S (1994) A simulation of action potentials in synaptic boutons during presynaptic inhibition. J Neurophysiol 71:538-49 [Journal] [PubMed]

Hamill OP, Huguenard JR, Prince DA (1991) Patch-clamp studies of voltage-gated currents in identified neurons of the rat cerebral cortex. Cereb Cortex 1:48-61 [PubMed]

Harris KM, Stevens JK (1989) Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. J Neurosci 9:2982-97 [PubMed]

Haug H (1968) [Quantitative examinations of electromicrographs on the structure of the myelinated fibers in cat's visual cortex] Brain Res 11:65-84 [PubMed]

Hines M (1993) NEURON--a program for simulation of nerve equations. Neural Systems: Analysis And Modeling, Eeckman F, ed. pp.127

Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Huguenard JR, Hamill OP, Prince DA (1988) Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component. J Neurophysiol 59:778-95 [Journal] [PubMed]

Huguenard JR, Hamill OP, Prince DA (1989) Sodium channels in dendrites of rat cortical pyramidal neurons. Proc Natl Acad Sci U S A 86:2473-7 [PubMed]

Jester JM, Campbell LW, Sejnowski TJ (1995) Associative EPSP--spike potentiation induced by pairing orthodromic and antidromic stimulation in rat hippocampal slices. J Physiol 484 ( Pt 3):689-705 [PubMed]

Kaars C, Faber DS (1981) Myelinated central vertebrate axon lacks voltage-sensitive potassium conductance. Science 212:1063-5 [PubMed]

Kobayashi T, Storrie B, Simons K, Dotti CG (1992) A functional barrier to movement of lipids in polarized neurons. Nature 359:647-50 [PubMed]

Larkman A, Mason A (1990) Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. I. Establishment of cell classes. J Neurosci 10:1407-14 [PubMed]

Larkman AU (1991) Dendritic morphology of pyramidal neurones of the visual cortex of the rat: III. Spine distributions. J Comp Neurol 306:332-43 [PubMed]

Li M, West JW, Lai Y, Scheuer T, Catterall WA (1992) Functional modulation of brain sodium channels by cAMP-dependent phosphorylation. Neuron 8:1151-9 [PubMed]

Lytton WW, Sejnowski TJ (1991) Simulations of cortical pyramidal neurons synchronized by inhibitory interneurons. J Neurophysiol 66:1059-79 [Journal] [PubMed]

Magee JC, Johnston D (1995) Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons. Science 268:301-4 [PubMed]

Mainen ZF, Sejnowski TJ (1995) Reliability of spike timing in neocortical neurons. Science 268:1503-6 [PubMed]

Major G, Larkman AU, Jonas P, Sakmann B, Jack JJ (1994) Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices. J Neurosci 14:4613-38 [PubMed]

Malinow R, Tsien RW (1990) Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature 346:177-80 [PubMed]

Mason A, Larkman A (1990) Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. II. Electrophysiology. J Neurosci 10:1415-28 [PubMed]

Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]

   Site of impulse initiation in a neuron (Moore et al 1983) [Model]

Moore JW, Westerfield M (1983) Action potential propagation and threshold parameters in inhomogeneous regions of squid axons. J Physiol 336:285-300 [PubMed]

Murphy BJ, Rossie S, De Jongh KS, Catterall WA (1993) Identification of the sites of selective phosphorylation and dephosphorylation of the rat brain Na+ channel alpha subunit by cAMP-dependent protein kinase and phosphoprotein phosphatases. J Biol Chem 268:27355-62 [PubMed]

Palay SL, Sotelo C, Peters A, Orkand PM (1968) The axon hillock and the initial segment. J Cell Biol 38:193-201 [PubMed]

Peters A, Proskauer CC, Kaiserman-Abramof IR (1968) The small pyramidal neuron of the rat cerebral cortex. The axon hillock and initial segment. J Cell Biol 39:604-19 [PubMed]

Pitler TA, Alger BE (1994) Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism. Neuron 13:1447-55 [PubMed]

Regehr W, Kehoe JS, Ascher P, Armstrong C (1993) Synaptically triggered action potentials in dendrites. Neuron 11:145-51 [PubMed]

Regehr WG, Konnerth A, Armstrong CM (1992) Sodium action potentials in the dendrites of cerebellar Purkinje cells. Proc Natl Acad Sci U S A 89:5492-6 [PubMed]

Rhodes PA, Gray CM (1994) Simulations of intrinsically bursting neocortical pyramidal neurons. Neural Computation 6:1086-1110

Sah P, Gibb AJ, Gage PW (1988) The sodium current underlying action potentials in guinea pig hippocampal CA1 neurons. J Gen Physiol 91:373-98 [PubMed]

Schuman EM, Madison DV (1994) Locally distributed synaptic potentiation in the hippocampus. Science 263:532-6 [PubMed]

Skaugen E (1980) Firing behaviour in nerve cell models with a two-state pore system. Acta Physiol Scand 109:377-92 [PubMed]

Softky WR (1995) Simple codes versus efficient codes. Curr Opin Neurobiol 5:239-47 [PubMed]

Spruston N, Jaffe DB, Johnston D (1994) Dendritic attenuation of synaptic potentials and currents: the role of passive membrane properties. Trends Neurosci 17:161-6 [PubMed]

Srinivasan Y, Elmer L, Davis J, Bennett V, Angelides K (1988) Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. Nature 333:177-80 [PubMed]

Stuart GJ, Sakmann B (1994) Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367:69-72 [PubMed]

Stuhmer W, Methfessel C, Sakmann B, Noda M, Numa S (1987) Patch clamp characterization of sodium channels expressed from rat brain cDNA. Eur Biophys J 14:131-8 [PubMed]

Traub RD, Jefferys JG, Miles R, Whittington MA, Toth K (1994) A branching dendritic model of a rodent CA3 pyramidal neurone. J Physiol 481 ( Pt 1):79-95 [PubMed]

Traub RD, Wong RK, Miles R, Michelson H (1991) A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J Neurophysiol 66:635-50 [Journal] [PubMed]

Vincent P, Marty A (1993) Neighboring cerebellar Purkinje cells communicate via retrograde inhibition of common presynaptic interneurons. Neuron 11:885-93 [PubMed]

Waxman SG, Ritchie JM (1993) Molecular dissection of the myelinated axon. Ann Neurol 33:121-36 [PubMed]

Westenbroek RE, Merrick DK, Catterall WA (1989) Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons. Neuron 3:695-704 [PubMed]

Westrum LE (1970) Observations on initial segments of axons in the prepyriform cortex of the rat. J Comp Neurol 139:337-56 [PubMed]

Wollner DA, Catterall WA (1986) Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells. Proc Natl Acad Sci U S A 83:8424-8 [PubMed]

Yuste R, Gutnick MJ, Saar D, Delaney KR, Tank DW (1994) Ca2+ accumulations in dendrites of neocortical pyramidal neurons: an apical band and evidence for two functional compartments. Neuron 13:23-43 [PubMed]

Akemann W, Lundby A, Mutoh H, Knopfel T (2009) Effect of voltage sensitive fluorescent proteins on neuronal excitability. Biophys J 96:3959-76 [Journal] [PubMed]

   Effect of voltage sensitive fluorescent proteins on neuronal excitability (Akemann et al. 2009) [Model]

Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI (2012) Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices J. Neurosci, 32(40):13644-60 [Journal] [PubMed]

   [10 reconstructed morphologies on NeuroMorpho.Org]
   Rhesus Monkey Layer 3 Pyramidal Neurons: V1 vs PFC (Amatrudo, Weaver et al. 2012) [Model]

Azouz R (2005) Dynamic spatiotemporal synaptic integration in cortical neurons: neuronal gain, revisited. J Neurophysiol 94:2785-96 [PubMed]

Azouz R, Gray CM (2008) Stimulus-selective spiking is driven by the relative timing of synchronous excitation and disinhibition in cat striate neurons in vivo. Eur J Neurosci 28:1286-300 [PubMed]

Bahl A, Stemmler MB, Herz AV, Roth A (2012) Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. J Neurosci Methods 210:22-34 [Journal] [PubMed]

   A set of reduced models of layer 5 pyramidal neurons (Bahl et al. 2012) [Model]

Baranauskas G,Martina M (2006) Sodium Currents Activate without a Hodgkin and Huxley- Type Delay in Central Mammalian Neurons J. Neurosci. 26(2):671-684 [PubMed]

   Sodium currents activate without a delay (Baranauskas and Martina 2006) [Model]

beim Graben P, Rodrigues S (2013) A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons Frontiers in Computational Neuroscience 6:1-13 [Journal] [PubMed]

   Biophysical model for field potentials of networks of I&F neurons (beim Graben & Serafim 2013) [Model]

Casale AE, McCormick DA (2011) Active action potential propagation but not initiation in thalamic interneuron dendrites. J Neurosci 31:18289-302 [Journal] [PubMed]

   Active dendritic action potential propagation (Casale & McCormick 2011) [Model]

Chitwood RA, Hubbard A, Jaffe DB (1999) Passive electrotonic properties of rat hippocampal CA3 interneurones. J Physiol 515 ( Pt 3):743-56 [PubMed]

   [66 reconstructed morphologies on NeuroMorpho.Org]

Clark BA, Monsivais P, Branco T, London M, Hausser M (2005) The site of action potential initiation in cerebellar Purkinje neurons. Nat Neurosci 8:137-9 [PubMed]

Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nat Neurosci 5:533-8 [PubMed]

Contreras D, Destexhe A, Steriade M (1997) Intracellular and computational characterization of the intracortical inhibitory control of synchronized thalamic inputs in vivo. J Neurophysiol 78:335-50 [Journal] [PubMed]

   [2 reconstructed morphologies on NeuroMorpho.Org]

Coskren PJ, Luebke JI, Kabaso D, Wearne SL, Yadav A, Rumbell T, Hof PR, Weaver CM (2015) Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. J Comput Neurosci 38:263-83 [Journal] [PubMed]

   [14 reconstructed morphologies on NeuroMorpho.Org]
   Rhesus Monkey Layer 3 Pyramidal Neurons: Young vs aged PFC (Coskren et al. 2015) [Model]

D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21:759-70 [PubMed]

   Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001) [Model]

Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci 16:169-85 [Journal] [PubMed]

   [1 reconstructed morphology on NeuroMorpho.Org]
   Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996) [Model]

Diwakar S, Magistretti J, Goldfarb M, Naldi G, D`Angelo E (2009) Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells J Neurophysiol 101(2):519-32 [Journal] [PubMed]

   Multicompartmental cerebellar granule cell model (Diwakar et al. 2009) [Model]

Doiron B, Laing C, Longtin A, Maler L (2002) Ghostbursting: a novel neuronal burst mechanism. J Comput Neurosci 12:5-25 [Journal] [PubMed]

Doiron B, Longtin A, Turner RW, Maler L (2001) Model of gamma frequency burst discharge generated by conditional backpropagation. J Neurophysiol 86:1523-45 [Journal] [PubMed]

Emri Z, Antal K, Crunelli V (2003) The impact of corticothalamic feedback on the output dynamics of a thalamocortical neurone model: the role of synapse location and metabotropic glutamate receptors. Neuroscience 117:229-39 [PubMed]

Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma. Nat Neurosci 13:852-60 [Journal] [PubMed]

   Action potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010) [Model]

Fleidervish IA, Libman L (2008) How cesium dialysis affects the passive properties of pyramidal neurons: implications for voltage clamp studies of persistent sodium current. Art. No. 035001 New Journal of Physics 10:1-13 [Journal]

Fleidervish IA, Libman L, Katz E, Gutnick MJ (2008) Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels. Proc Natl Acad Sci U S A 105:18994-9 [Journal] [PubMed]

Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA (2011) Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons The Journal of Neuroscience 31(43):15490-15498 [Journal] [PubMed]

   Spike repolarization in axon collaterals (Foust et al. 2011) [Model]

Foutz TJ, Arlow RL, McIntyre CC (2012) Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron J Neurophysiol. 107(12):3235-45 [Journal] [PubMed]

   Optical stimulation of a channelrhodopsin-2 positive pyramidal neuron model (Foutz et al 2012) [Model]

Franks KM, Bartol TM, Sejnowski TJ (2001) An MCell model of calcium dynamics and frequency-dependence of calmodulin activation in dendritic spines Neurocomputing 38:9-16

Frey U, Egert U, Heer F, Hafizovic S, Hierlemann A (2009) Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices. Biosens Bioelectron 24:2191-8 [Journal] [PubMed]

Gleeson P, Steuber V, Silver RA (2007) neuroConstruct: a tool for modeling networks of neurons in 3D space. Neuron 54:219-35 [Journal] [PubMed]

Gold C, Henze DA, Koch C (2007) Using Extracellular Action Potential Recordings to Tune Compartmental Models. Journal of Computational Neuroscience 23:39-58 [Journal] [PubMed]

   Extracellular Action Potential Simulations (Gold et al 2007) [Model]

Gold C, Henze DA, Koch C, Buzsaki G (2006) On the origin of the extracellular action potential waveform: A modeling study. J Neurophysiol 95:3113-28 [Journal] [PubMed]

   Extracellular Action Potential Simulations (Gold et al 2007) [Model]

Golding NL, Kath WL, Spruston N (2001) Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. J Neurophysiol 86:2998-3010 [Journal] [PubMed]

   [22 reconstructed morphologies on NeuroMorpho.Org]
   Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001) [Model]

Gurkiewicz M, Korngreen A, Waxman SG, Lampert A (2011) Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation. J Neurophysiol [Journal] [PubMed]

   HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011) [Model]

Haag J, Theunissen F, Borst A (1997) The intrinsic electrophysiological characteristics of fly lobula plate tangential cells: II. Active membrane properties. J Comput Neurosci 4:349-69 [Journal] [PubMed]

   Fly lobular plate VS cell (Borst and Haag 1996, et al. 1997, et al. 1999) [Model]

Haeusler S, Maass W (2006) A Statistical Analysis of Information-Processing Properties of Lamina-Specific Cortical Microcircuit Models. Cereb Cortex : [PubMed]

   Information-processing in lamina-specific cortical microcircuits (Haeusler and Maass 2006) [Model]

Hay E, Schurmann F, Markram H, Segev I (2013) Preserving Axo-somatic Spiking Features Despite Diverse Dendritic Morphology. J Neurophysiol 109(12):2972-81 [Journal] [PubMed]

   [4 reconstructed morphologies on NeuroMorpho.Org]
   Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013) [Model]

Hines ML, Carnevale NT (2003) Personal Communication of NEURON bibliography

Hoffman DA, Magee JC, Colbert CM, Johnston D (1997) K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387:869-75 [PubMed]

Holt GR, Koch C (1999) Electrical interactions via the extracellular potential near cell bodies. J Comput Neurosci 6:169-84 [Journal] [PubMed]

   Extracellular Action Potential Simulations (Gold et al 2007) [Model]

Howard AL, Neu A, Morgan RJ, Echegoyen JC, Soltesz I (2007) Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network. J Neurophysiol 97:2394-409 [Journal] [PubMed]

Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12:996-1002 [Journal] [PubMed]

   Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]

Iannella N, Tanaka S (2006) Synaptic efficacy cluster formation across the dendrite via STDP. Neurosci Lett 403:24-9 [Journal] [PubMed]

Jacobson GA, Diba K, Yaron-Jakoubovitch A, Oz Y, Koch C, Segev I, Yarom Y (2005) Subthreshold voltage noise of rat neocortical pyramidal neurones. J Physiol 564:145-60 [PubMed]

Jaffe DB, Carnevale NT (1999) Passive normalization of synaptic integration influenced by dendritic architecture. J Neurophysiol 82:3268-85 [Journal] [PubMed]

   [66 reconstructed morphologies on NeuroMorpho.Org]

Jones SR, Pinto DJ, Kaper TJ, Kopell N (2001) Alpha-frequency rhythms desynchronize over long cortical distances: a modeling study. J Comput Neurosci 9:271-91 [Journal] [PubMed]

Keren N, Peled N, Korngreen A (2005) Constraining compartmental models using multiple voltage recordings and genetic algorithms. J Neurophysiol 94:3730-42 [Journal] [PubMed]

Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. Elife [Journal] [PubMed]

   CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015) [Model]

Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86 [Journal] [PubMed]

   Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008) [Model]

Korngreen A, Sakmann B (2000) Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. J Physiol 525 Pt 3:621-39 [PubMed]

   Pyramidal Neuron Deep: K+ kinetics (Korngreen, Sakmann 2000) [Model]

Larkum ME, Launey T, Dityatev A, Luscher HR (1998) Integration of excitatory postsynaptic potentials in dendrites of motoneurons of rat spinal cord slice cultures. J Neurophysiol 80:924-35 [Journal] [PubMed]

Luscher HR, Larkum ME (1998) Modeling action potential initiation and back-propagation in dendrites of cultured rat motoneurons. J Neurophysiol 80:715-29 [Journal] [PubMed]

Maass W, Joshi P, Sontag ED (2007) Computational aspects of feedback in neural circuits. PLoS Comput Biol 3(1):e165 [PubMed]

   Computational aspects of feedback in neural circuits (Maass et al 2006) [Model]

Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 [Journal] [PubMed]

   [2 reconstructed morphologies on NeuroMorpho.Org]
   Pyramidal Neuron Deep, Superficial; Aspiny, Stellate (Mainen and Sejnowski 1996) [Model]

Masurkar AV, Chen WR (2011) Potassium currents of olfactory bulb juxtaglomerular cells: characterization, simulation, and implications for plateau potential firing. Neuroscience 192:247-262 [Journal] [PubMed]

   Calcium and potassium currents of olfactory bulb juxtaglomerular cells (Masurkar and Chen 2011) [Model]

Masurkar AV, Chen WR (2011) Calcium currents of olfactory bulb juxtaglomerular cells: Profile and multiple conductance plateau potential simulation. Neuroscience 192:231-46 [Journal] [PubMed]

   Calcium and potassium currents of olfactory bulb juxtaglomerular cells (Masurkar and Chen 2011) [Model]

Mattioni M, Cohen U, Le Novere N (2012) Neuronvisio: A Graphical User Interface with 3D Capabilities for NEURON. Front Neuroinform 6:20 [Journal] [PubMed]

   Neuronvisio: a gui with 3D capabilities for NEURON (Mattioni et al. 2012) [Model]

McIntyre CC, Grill WM (1999) Excitation of central nervous system neurons by nonuniform electric fields. Biophys J 76:878-88 [PubMed]

Meeks JP, Mennerick S (2007) Action potential initiation and propagation in CA3 pyramidal axons. J Neurophysiol 97:3460-72 [PubMed]

Migliore M (1996) Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons. Biophys J 71:2394-403 [Journal] [PubMed]

   CA1 Pyramidal Neuron: slow Na+ inactivation (Migliore 1996) [Model]

Migliore M, Hoffman DA, Magee JC, Johnston D (1999) Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J Comput Neurosci 7:5-15 [Journal] [PubMed]

   CA1 pyramidal neuron (Migliore et al 1999) [Model]

Morita K (2008) Possible role of dendritic compartmentalization in the spatial working memory circuit. J Neurosci 28:7699-724 [Journal] [PubMed]

   Working memory circuit with branched dendrites (Morita 2008) [Model]

Nenadic Z, Burdick JW (2006) A control algorithm for autonomous optimization of extracellular recordings. IEEE Trans Biomed Eng 53:941-55 [Journal] [PubMed]

Omurtag A, Lytton WW (2010) Spectral method and high-order finite differences for the nonlinear cable equation. Neural Comput 22:2113-36 [Journal] [PubMed]

   Spectral method and high-order finite differences for nonlinear cable (Omurtag and Lytton 2010) [Model]

Ostroumov K (2007) A new stochastic tridimensional model of neonatal rat spinal motoneuron for investigating compartmentalization of neuronal conductances and their influence on firing. J Neurosci Methods 163(2):362-72 [Journal] [PubMed]

   Stochastic 3D model of neonatal rat spinal motoneuron (Ostroumov 2007) [Model]

Pare D, Lang EJ, Destexhe A (1998) Inhibitory control of somatodendritic interactions underlying action potentials in neocortical pyramidal neurons in vivo: an intracellular and computational study. Neuroscience 84:377-402 [PubMed]

Platkiewicz J, Brette R (2010) A threshold equation for action potential initiation. PLoS Comput Biol 6:e1000850 [Journal] [PubMed]

   A threshold equation for action potential initiation (Platkiewicz & Brette 2010) [Model]

Prescott SA, De Koninck Y (2003) Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc Natl Acad Sci U S A 100:2076-81 [PubMed]

Prescott SA, De Koninck Y (2005) Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. J Neurosci 25:4743-54 [Journal] [PubMed]

   Tonic neuron in spinal lamina I: prolongation of subthreshold depol. (Prescott and De Koninck 2005) [Model]

Prescott SA, Sejnowski TJ, De Koninck Y (2006) Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain. Mol Pain 2:32 [PubMed]

Rapp M, Yarom Y, Segev I (1996) Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells. Proc Natl Acad Sci U S A 93:11985-90 [PubMed]

Rhodes PA, Llinas RR (2001) Apical tuft input efficacy in layer 5 pyramidal cells from rat visual cortex. J Physiol 536:167-87 [PubMed]

Rudolph M, Destexhe A (2003) A fast-conducting, stochastic integrative mode for neocortical neurons in vivo. J Neurosci 23:2466-76 [PubMed]

Safronov BV, Wolff M, Vogel W (2000) Excitability of the soma in central nervous system neurons. Biophys J 78:2998-3010 [PubMed]

   Excitability of the soma in central nervous system neurons (Safronov et al 2000) [Model]

Saraga F, Wu CP, Zhang L, Skinner FK (2003) Active Dendrites and Spike Propagation in Multi-compartment Models of Oriens-Lacunosum/Moleculare Hippocampal Interneurons. J Physiol 552(3):673-689 [Journal] [PubMed]

   Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003) [Model]

Schaefer AT, Helmstaedter M, Sakmann B, Korngreen A (2003) Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated k(+) channels. Biophys J 84:3508-28 [PubMed]

   Correcting space clamp in dendrites (Schaefer et al. 2003 and 2007) [Model]

Schaefer AT, Helmstaedter M, Schmitt AC, Bar-Yehuda D, Almog M, Ben-Porat H, Sakmann B, Korng (2007) Dendritic voltage-gated K+ conductance gradient in pyramidal neurones of neocortical layer 5B from rats. J Physiol 579:737-52 [PubMed]

   Correcting space clamp in dendrites (Schaefer et al. 2003 and 2007) [Model]

Schaefer AT, Larkum ME, Sakmann B, Roth A (2003) Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. J Neurophysiol 89:3143-54 [Journal] [PubMed]

   Pyramidal neuron coincidence detection tuned by dendritic branching pattern (Schaefer et al 2003) [Model]

Schmidt-Hieber C, Bischofberger J (2010) Fast Sodium Channel Gating Supports Localized and Efficient Axonal Action Potential Initiation J. Neurosci. 30(30):10233-10242 [Journal] [PubMed]

   Fast sodium channel gating in mossy fiber axons (Schmidt-Hieber et al. 2010) [Model]

Segev I, Rall W (1998) Excitable dendrites and spines: earlier theoretical insights elucidate recent direct observations. Trends Neurosci 21:453-60 [PubMed]

Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [Journal] [PubMed]

   Action potential initiation in the olfactory mitral cell (Shen et al 1999) [Model]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. J Neurophysiol 97:746-60 [Journal] [PubMed]

   Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441:761-5 [Journal] [PubMed]

   Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]

Steinmetz PN, Manwani A, Koch C, London M, Segev I (2001) Subthreshold voltage noise due to channel fluctuations in active neuronal membranes. J Comput Neurosci 9:133-48 [Journal] [PubMed]

Stiefel KM, Wespatat V, Singer W, Tennigkeit F (2001) A computational model of the interaction of membrane potential oscillations with inhibitory synaptic input in cortical cells Neurocomputing 38:389-395

Stuart G, Spruston N, Sakmann B, Hausser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20:125-31 [PubMed]

Stuart GJ, Hausser M (2001) Dendritic coincidence detection of EPSPs and action potentials. Nat Neurosci 4:63-71 [PubMed]

Tang AC, Bartels AM, Sejnowski TJ (1997) Effects of cholinergic modulation on responses of neocortical neurons to fluctuating input. Cereb Cortex 7:502-9 [PubMed]

Toth TI, Crunelli V (1998) Effects of tapering geometry and inhomogeneous ion channel distribution in a neuron model. Neuroscience 84:1223-32 [PubMed]

Toth TI, Crunelli V (1999) Solution of the nerve cable equation using Chebyshev approximations. J Neurosci Methods 87:119-36 [PubMed]

Vetter P, Roth A, Hausser M (2001) Propagation of action potentials in dendrites depends on dendritic morphology. J Neurophysiol 85:926-37 [Journal] [PubMed]

   [13 reconstructed morphologies on NeuroMorpho.Org]
   Dendritica (Vetter et al 2001) [Model]

Wang K, Riera J, Enjieu-Kadji H, Kawashima R (2013) The Role of Extracellular Conductivity Profiles in Compartmental Models for Neurons: Particulars for Layer 5 Pyramidal Cells Neural Comput 25(7):1807-52 [Journal] [PubMed]

   Modeling conductivity profiles in the deep neocortical pyramidal neuron (Wang K et al. 2013) [Model]

Williams SR, Christensen SR, Stuart GJ, Hausser M (2002) Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro. J Physiol 539:469-83 [PubMed]

Xiang Z, Huguenard JR, Prince DA (2002) Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex. J Neurophysiol 88:740-50 [Journal] [PubMed]

Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. J Neurosci 28:7260-72 [Journal] [PubMed]

   AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008) [Model]

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