Homosynaptic plasticity in the tail withdrawal circuit (TWC) of Aplysia (Baxter and Byrne 2006)

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Accession:83472
The tail-withdrawal circuit of Aplysia provides a useful model system for investigating synaptic dynamics. Sensory neurons within the circuit manifest several forms of synaptic plasticity. Here, we developed a model of the circuit and investigated the ways in which depression (DEP) and potentiation (POT) contributed to information processing. DEP limited the amount of motor neuron activity that could be elicited by the monosynaptic pathway alone. POT within the monosynaptic pathway did not compensate for DEP. There was, however, a synergistic interaction between POT and the polysynaptic pathway. This synergism extended the dynamic range of the network, and the interplay between DEP and POT made the circuit respond preferentially to long-duration, low-frequency inputs.
Reference:
1 . Baxter DA, Byrne JH (2007) Short-term plasticity in a computational model of the tail-withdrawal circuit in Aplysia Neurocomputing 70(10-12):1993-1999
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Aplysia;
Cell Type(s): Aplysia sensory neuron; Aplysia interneuron; Aplysia motor neuron;
Channel(s): I N; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: SNNAP;
Model Concept(s): Synchronization; Synaptic Plasticity; Short-term Synaptic Plasticity; Action Potentials; Facilitation; Post-Tetanic Potentiation; Depression; Sensory processing;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  AMPA; I N; I K; I Sodium; I Potassium; Glutamate;
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PSM[MN.>----.SN_1.exc.]<{svr}	0.17098080931294832	1.0
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At[MN.>----.SN_2.exc.]<{svr}	0.0	0.05697659628511286
PSM[MN.>----.SN_2.exc.]<{svr}	0.17033067376669347	1.0
At[MN.>----.SN_3.exc.]<{svr}	-1.139515603955497	19.880699249570775
At[MN.>----.SN_3.exc.]<{svr}	0.0	0.057051542997643
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At[MN.>----.SN_4.exc.]<{svr}	-1.1410526276596267	19.880699249570775
At[MN.>----.SN_4.exc.]<{svr}	0.0	0.057128493977487364
PSM[MN.>----.SN_4.exc.]<{svr}	0.1690548162189824	1.0
At[LP_1.>----.SN_1.exc.]<{svr}	-1.136496535054528	19.880699249570775
At[LP_1.>----.SN_1.exc.]<{svr}	0.0	0.0569003935352573
PSM[LP_1.>----.SN_1.exc.]<{svr}	0.17098080931294832	1.0
At[LP_1.>----.SN_2.exc.]<{svr}	-1.1380186135972035	19.880699249570775
At[LP_1.>----.SN_2.exc.]<{svr}	0.0	0.05697659628511286
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At[LP_1.>----.SN_3.exc.]<{svr}	-1.139515603955497	19.880699249570775
At[LP_1.>----.SN_3.exc.]<{svr}	0.0	0.057051542997643
PSM[LP_1.>----.SN_3.exc.]<{svr}	0.16969241768962787	1.0
At[LP_1.>----.SN_4.exc.]<{svr}	-1.1410526276596267	19.880699249570775
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At[LP_2.>----.SN_1.exc.]<{svr}	-1.136496535054528	19.880699249570775
At[LP_2.>----.SN_1.exc.]<{svr}	0.0	0.0569003935352573
PSM[LP_2.>----.SN_1.exc.]<{svr}	0.17098080931294832	1.0
At[LP_2.>----.SN_2.exc.]<{svr}	-1.1380186135972035	19.880699249570775
At[LP_2.>----.SN_2.exc.]<{svr}	0.0	0.05697659628511286
PSM[LP_2.>----.SN_2.exc.]<{svr}	0.17033067376669347	1.0
At[LP_2.>----.SN_3.exc.]<{svr}	-1.139515603955497	19.880699249570775
At[LP_2.>----.SN_3.exc.]<{svr}	0.0	0.057051542997643
PSM[LP_2.>----.SN_3.exc.]<{svr}	0.16969241768962787	1.0
At[LP_2.>----.SN_4.exc.]<{svr}	-1.1410526276596267	19.880699249570775
At[LP_2.>----.SN_4.exc.]<{svr}	0.0	0.057128493977487364
PSM[LP_2.>----.SN_4.exc.]<{svr}	0.1690548162189824	1.0
At[MN.>----.LP_1.excS.]<{svr}	-0.0031082086515318934	0.009696852429459822
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At[MN.>----.LP_2.excF.]<{svr}	0.0	0.06508476512963196
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one	0.0	0.0
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dAt[MN.>----.SN_2.exc.]/dt<{tvr}	-1.1380186135972035	19.880699249570775
dPSM[MN.>----.SN_2.exc.]/dt<{tvr}	-100.0	1.1852418946190095
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dAt[MN.>----.SN_3.exc.]/dt<{tvr}	-1.139515603955497	19.880699249570775
dPSM[MN.>----.SN_3.exc.]/dt<{tvr}	-100.0	1.1861536890148174
dAt[MN.>----.SN_4.exc.]/dt<{tvr}	-1527655.0800027852	1999000.2499583382
dAt[MN.>----.SN_4.exc.]/dt<{tvr}	-1.1410526276596267	19.880699249570775
dPSM[MN.>----.SN_4.exc.]/dt<{tvr}	-100.0	1.1870645482585966
dAt[LP_1.>----.SN_1.exc.]/dt<{tvr}	-1527655.0800027852	1999000.2499583382
dAt[LP_1.>----.SN_1.exc.]/dt<{tvr}	-1.136496535054528	19.880699249570775
dPSM[LP_1.>----.SN_1.exc.]/dt<{tvr}	-100.0	1.184313129552931
dAt[LP_1.>----.SN_2.exc.]/dt<{tvr}	-1527655.0800027852	1999000.2499583382
dAt[LP_1.>----.SN_2.exc.]/dt<{tvr}	-1.1380186135972035	19.880699249570775
dPSM[LP_1.>----.SN_2.exc.]/dt<{tvr}	-100.0	1.1852418946190095
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dAt[LP_1.>----.SN_3.exc.]/dt<{tvr}	-1.139515603955497	19.880699249570775
dPSM[LP_1.>----.SN_3.exc.]/dt<{tvr}	-100.0	1.1861536890148174
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dAt[LP_1.>----.SN_4.exc.]/dt<{tvr}	-1.1410526276596267	19.880699249570775
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dAt[LP_2.>----.SN_2.exc.]/dt<{tvr}	-1.1380186135972035	19.880699249570775
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dAt[LP_2.>----.SN_3.exc.]/dt<{tvr}	-1.139515603955497	19.880699249570775
dPSM[LP_2.>----.SN_3.exc.]/dt<{tvr}	-100.0	1.1861536890148174
dAt[LP_2.>----.SN_4.exc.]/dt<{tvr}	-1527655.0800027852	1999000.2499583382
dAt[LP_2.>----.SN_4.exc.]/dt<{tvr}	-1.1410526276596267	19.880699249570775
dPSM[LP_2.>----.SN_4.exc.]/dt<{tvr}	-100.0	1.1870645482585966
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dAt[MN.>----.LP_1.excS.]/dt<{tvr}	-0.0031082086515318934	0.009696852429459822
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dAt[MN.>----.LP_2.excS.]/dt<{tvr}	-0.0031082086515318934	0.009696852429459822
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dAt[MN.>----.LP_1.excF.]/dt<{tvr}	-1.2999714757614327	19.973576516360243
dPSM[MN.>----.LP_1.excF.]/dt<{tvr}	0.0	0.0
dAt[MN.>----.LP_2.excF.]/dt<{tvr}	-2000376.7069250906	2000002.8905870644
dAt[MN.>----.LP_2.excF.]/dt<{tvr}	-1.2999714757614327	19.973576516360243
dPSM[MN.>----.LP_2.excF.]/dt<{tvr}	0.0	0.0
zero	0.0	0.0
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sIvd_reg[SN_1....]<{ivr}	-45.660789787399125	18.43800806217815
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pTBI[GLU.SN_1...]<{ivr}	1.0	1.0
pTBS[GLU.SN_1...]<{ivr}	1.0	1.0
Ivd[Na.SN_1...]<{ivr}	-136.12912773869485	-4.19515435000031E-5
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Gvd[Na.SN_1...]<{ivr}	3.2977950256492595E-7	3.6393960318670024
A[Na.SN_1...]<{ivr}	0.003559943839871953	0.999052220337942
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IVDxREG[Na.SN_1...]<{ivr}	-136.12912773869485	-4.19515435000031E-5
Ivd[K.SN_1...]<{ivr}	5.1791721455226946E-5	144.00607041236347
pGBI[K.SN_1...]<{ivr}	1.0	1.0
pGBS[K.SN_1...]<{ivr}	1.0	1.0
Gvd[K.SN_1...]<{ivr}	5.179172145522694E-6	2.4182347414022134
A[K.SN_1...]<{ivr}	0.02005753653785041	0.5243087667765356
ssA[K.SN_1...]<{ivr}	0.007440214973727217	0.9999058370679783
tA[K.SN_1...]<{ivr}	0.008076707894661632	0.07980409144719483
IVDxREG[K.SN_1...]<{ivr}	5.1791721455226946E-5	144.00607041236347
Ivd[leak.SN_1...]<{ivr}	-0.9040487543233567	11.84335081047177
pGBI[leak.SN_1...]<{ivr}	1.0	1.0
pGBS[leak.SN_1...]<{ivr}	1.0	1.0
Gvd[leak.SN_1...]<{ivr}	0.1	0.1
IVDxREG[leak.SN_1...]<{ivr}	-0.9040487543233567	11.84335081047177
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sIex[SN_2....]<{ivr}	0.0	9.2
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spk[SN_2....]<{ivr}	0.0	1.0
spknow[SN_2....]<{ivr}	0.0	1.0
tfin_spk[SN_2....]<{ivr}	0.0	1.093020000002907
TR[GLU.SN_2...]<{ivr}	1.0	1.6947528014025932
ssTR[GLU.SN_2...]<{ivr}	1.0	1.0
pTBI[GLU.SN_2...]<{ivr}	1.0	1.0
pTBS[GLU.SN_2...]<{ivr}	1.0	1.0
Ivd[Na.SN_2...]<{ivr}	-136.1137780108419	-4.1519183674164325E-5
pGBI[Na.SN_2...]<{ivr}	1.0	1.0
pGBS[Na.SN_2...]<{ivr}	1.0	1.0
Gvd[Na.SN_2...]<{ivr}	3.263377722334221E-7	3.640395621353698
A[Na.SN_2...]<{ivr}	0.003548386665544942	0.9990527767086799
ssA[Na.SN_2...]<{ivr}	0.002447877181956737	0.9999999965773236
tA[Na.SN_2...]<{ivr}	0.001000000000029207	0.005987791353064837
B[Na.SN_2...]<{ivr}	0.12372024370871447	0.9714648669728859
ssB[Na.SN_2...]<{ivr}	1.0308902829261493E-9	0.9919186584019241
tB[Na.SN_2...]<{ivr}	0.005000794002251475	0.019221426491497485
IVDxREG[Na.SN_2...]<{ivr}	-136.1137780108419	-4.1519183674164325E-5
Ivd[K.SN_2...]<{ivr}	5.1791721455226946E-5	144.0865892247032
pGBI[K.SN_2...]<{ivr}	1.0	1.0
pGBS[K.SN_2...]<{ivr}	1.0	1.0
Gvd[K.SN_2...]<{ivr}	5.179172145522694E-6	2.4196743080271172
A[K.SN_2...]<{ivr}	0.02005753653785041	0.5243867791540914
ssA[K.SN_2...]<{ivr}	0.0074320726712198745	0.9999061577656476
tA[K.SN_2...]<{ivr}	0.00807647295751535	0.07980428532997377
IVDxREG[K.SN_2...]<{ivr}	5.1791721455226946E-5	144.0865892247032
Ivd[leak.SN_2...]<{ivr}	-0.9050416041141744	11.846421527327939
pGBI[leak.SN_2...]<{ivr}	1.0	1.0
pGBS[leak.SN_2...]<{ivr}	1.0	1.0
Gvd[leak.SN_2...]<{ivr}	0.1	0.1
IVDxREG[leak.SN_2...]<{ivr}	-0.9050416041141744	11.846421527327939
V[SN_3....]<{ivr}	-79.05703700972688	48.49494711513427
sIex[SN_3....]<{ivr}	0.0	9.3
sIlight[SN_3....]<{ivr}	0.0	0.0
slightOn[SN_3....]<{ivr}	0.0	0.0
sIvd_reg[SN_3....]<{ivr}	-45.46298951513485	18.64174533653337
sIld[SN_3....]<{ivr}	0.0	0.0
sIcs[SN_3....]<{ivr}	0.0	0.0
sIes[SN_3....]<{ivr}	0.0	0.0
spk[SN_3....]<{ivr}	0.0	1.0
spknow[SN_3....]<{ivr}	0.0	1.0
tfin_spk[SN_3....]<{ivr}	0.0	1.088565000002878
TR[GLU.SN_3...]<{ivr}	1.0	1.6950819954785339
ssTR[GLU.SN_3...]<{ivr}	1.0	1.0
pTBI[GLU.SN_3...]<{ivr}	1.0	1.0
pTBS[GLU.SN_3...]<{ivr}	1.0	1.0
Ivd[Na.SN_3...]<{ivr}	-136.09616920788906	-4.1222612918973746E-5
pGBI[Na.SN_3...]<{ivr}	1.0	1.0
pGBS[Na.SN_3...]<{ivr}	1.0	1.0
Gvd[Na.SN_3...]<{ivr}	3.239795926077356E-7	3.6413709996515036
A[Na.SN_3...]<{ivr}	0.003541374773664038	0.9990533311126829
ssA[Na.SN_3...]<{ivr}	0.0024446457825741813	0.9999999965982962
tA[Na.SN_3...]<{ivr}	0.0010000000000289833	0.005987811495395266
B[Na.SN_3...]<{ivr}	0.12368705749316349	0.9713910906111437
ssB[Na.SN_3...]<{ivr}	1.0245734840762852E-9	0.9919292662716719
tB[Na.SN_3...]<{ivr}	0.005000791566010506	0.01922191508108488
IVDxREG[Na.SN_3...]<{ivr}	-136.09616920788906	-4.1222612918973746E-5
Ivd[K.SN_3...]<{ivr}	5.1791721455226946E-5	144.1648767204082
pGBI[K.SN_3...]<{ivr}	1.0	1.0
pGBS[K.SN_3...]<{ivr}	1.0	1.0
Gvd[K.SN_3...]<{ivr}	5.179172145522694E-6	2.421079610928109
A[K.SN_3...]<{ivr}	0.02005753653785041	0.5244629011570863
ssA[K.SN_3...]<{ivr}	0.007426647769940994	0.9999064776275612
tA[K.SN_3...]<{ivr}	0.008076238551253546	0.07980441451726486
IVDxREG[K.SN_3...]<{ivr}	5.1791721455226946E-5	144.1648767204082
Ivd[leak.SN_3...]<{ivr}	-0.9057037009726884	11.849494711513428
pGBI[leak.SN_3...]<{ivr}	1.0	1.0
pGBS[leak.SN_3...]<{ivr}	1.0	1.0
Gvd[leak.SN_3...]<{ivr}	0.1	0.1
IVDxREG[leak.SN_3...]<{ivr}	-0.9057037009726884	11.849494711513428
V[SN_4....]<{ivr}	-79.05570050944169	48.525675865587516
sIex[SN_4....]<{ivr}	0.0	9.4
sIlight[SN_4....]<{ivr}	0.0	0.0
slightOn[SN_4....]<{ivr}	0.0	0.0
sIvd_reg[SN_4....]<{ivr}	-45.364096960257406	18.743626229669264
sIld[SN_4....]<{ivr}	0.0	0.0
sIcs[SN_4....]<{ivr}	0.0	0.0
sIes[SN_4....]<{ivr}	0.0	0.0
spk[SN_4....]<{ivr}	0.0	1.0
spknow[SN_4....]<{ivr}	0.0	1.0
tfin_spk[SN_4....]<{ivr}	0.0	1.084160000002849
TR[GLU.SN_4...]<{ivr}	1.0	1.6954079463311056
ssTR[GLU.SN_4...]<{ivr}	1.0	1.0
pTBI[GLU.SN_4...]<{ivr}	1.0	1.0
pTBS[GLU.SN_4...]<{ivr}	1.0	1.0
Ivd[Na.SN_4...]<{ivr}	-136.0763386597174	-4.1281946273010185E-5
pGBI[Na.SN_4...]<{ivr}	1.0	1.0
pGBS[Na.SN_4...]<{ivr}	1.0	1.0
Gvd[Na.SN_4...]<{ivr}	3.244514738429735E-7	3.642321142509863
A[Na.SN_4...]<{ivr}	0.0035428209231314653	0.9990538769268179
ssA[Na.SN_4...]<{ivr}	0.0024452977257701704	0.9999999966191382
tA[Na.SN_4...]<{ivr}	0.0010000000000287615	0.00598780743216233
B[Na.SN_4...]<{ivr}	0.12365338759427574	0.971402563325452
ssB[Na.SN_4...]<{ivr}	1.0182960211177581E-9	0.9919271260937359
tB[Na.SN_4...]<{ivr}	0.0050007891374882155	0.019221816478366856
IVDxREG[Na.SN_4...]<{ivr}	-136.0763386597174	-4.1281946273010185E-5
Ivd[K.SN_4...]<{ivr}	5.1791721455226946E-5	144.24096925353803
pGBI[K.SN_4...]<{ivr}	1.0	1.0
pGBS[K.SN_4...]<{ivr}	1.0	1.0
Gvd[K.SN_4...]<{ivr}	5.179172145522694E-6	2.422451216749632
A[K.SN_4...]<{ivr}	0.02005753653785041	0.5245371659179614
ssA[K.SN_4...]<{ivr}	0.007427742516912119	0.9999067963673135
tA[K.SN_4...]<{ivr}	0.00807600488621004	0.07980438844653526
IVDxREG[K.SN_4...]<{ivr}	5.1791721455226946E-5	144.24096925353803
Ivd[leak.SN_4...]<{ivr}	-0.9055700509441693	11.852567586558752
pGBI[leak.SN_4...]<{ivr}	1.0	1.0
pGBS[leak.SN_4...]<{ivr}	1.0	1.0
Gvd[leak.SN_4...]<{ivr}	0.1	0.1
IVDxREG[leak.SN_4...]<{ivr}	-0.9055700509441693	11.852567586558752
V[MN....]<{ivr}	-78.10507529706857	41.755049272549584
sIex[MN....]<{ivr}	0.0	0.0
sIlight[MN....]<{ivr}	0.0	0.0
slightOn[MN....]<{ivr}	0.0	0.0
sIvd_reg[MN....]<{ivr}	-110.86077614598754	39.087606873231145
sIld[MN....]<{ivr}	0.0	0.0
sIcs[MN....]<{ivr}	-4.6950752113587155	5.903266815098496
sIes[MN....]<{ivr}	0.0	0.0
spk[MN....]<{ivr}	0.0	1.0
spknow[MN....]<{ivr}	0.0	1.0
tfin_spk[MN....]<{ivr}	0.0	4.3256449999209385
Ivd[Na.MN...]<{ivr}	-114.86684884566472	-8.801389167009391E-5
pGBI[Na.MN...]<{ivr}	1.0	1.0
pGBS[Na.MN...]<{ivr}	1.0	1.0
Gvd[Na.MN...]<{ivr}	6.989440026640059E-7	3.2445736145796835
A[Na.MN...]<{ivr}	0.004610233436814304	0.9992737660112911
ssA[Na.MN...]<{ivr}	0.0029558315360022386	0.9999999869046663
tA[Na.MN...]<{ivr}	0.0010000000001562873	0.005984546602198757
B[Na.MN...]<{ivr}	0.10107527093299996	0.959138504330455
ssB[Na.MN...]<{ivr}	3.944238783897481E-9	0.9902531364660518
tB[Na.MN...]<{ivr}	0.005001553013152557	0.019148614957022293
IVDxREG[Na.MN...]<{ivr}	-114.86684884566472	-8.801389167009391E-5
Ivd[K.MN...]<{ivr}	5.1791721455226946E-5	130.99958234400998
pGBI[K.MN...]<{ivr}	1.0	1.0
pGBS[K.MN...]<{ivr}	1.0	1.0
Gvd[K.MN...]<{ivr}	5.179172145522694E-6	2.1381828008618853
A[K.MN...]<{ivr}	0.02005753653785041	0.5084212726237693
ssA[K.MN...]<{ivr}	0.008248405069974913	0.9998022558573555
tA[K.MN...]<{ivr}	0.008149431616715901	0.07978493884320029
IVDxREG[K.MN...]<{ivr}	5.1791721455226946E-5	130.99958234400998
Ivd[leak.MN...]<{ivr}	-1.7404386367110882	8.02816151571279
pGBI[leak.MN...]<{ivr}	1.0	1.0
pGBS[leak.MN...]<{ivr}	1.0	1.0
Gvd[leak.MN...]<{ivr}	0.0815	0.0815
IVDxREG[leak.MN...]<{ivr}	-1.7404386367110882	8.02816151571279
V[LP_1....]<{ivr}	-78.2042251582185	45.07200056469444
sIex[LP_1....]<{ivr}	0.0	0.0
sIlight[LP_1....]<{ivr}	0.0	0.0
slightOn[LP_1....]<{ivr}	0.0	0.0
sIvd_reg[LP_1....]<{ivr}	-52.37654632517759	8.842121821623682
sIld[LP_1....]<{ivr}	0.0	0.0
sIcs[LP_1....]<{ivr}	-4.9593299822605905	1.795635692404105
sIes[LP_1....]<{ivr}	0.0	0.0
spk[LP_1....]<{ivr}	0.0	1.0
spknow[LP_1....]<{ivr}	0.0	1.0
tfin_spk[LP_1....]<{ivr}	0.0	1.0075450000023471
TR[GLU.LP_1...]<{ivr}	1.0	1.2470229558718462
ssTR[GLU.LP_1...]<{ivr}	1.0	1.0
pTBI[GLU.LP_1...]<{ivr}	1.0	1.0
pTBS[GLU.LP_1...]<{ivr}	1.0	1.0
Ivd[Na.LP_1...]<{ivr}	-123.5735794611175	-1.6216455674961905E-4
pGBI[Na.LP_1...]<{ivr}	1.0	1.0
pGBS[Na.LP_1...]<{ivr}	1.0	1.0
Gvd[Na.LP_1...]<{ivr}	1.297316577527477E-6	3.5504504092626825
A[Na.LP_1...]<{ivr}	0.005486298899450404	0.9990317833584326
ssA[Na.LP_1...]<{ivr}	0.002897963002087032	0.9999999932545667
tA[Na.LP_1...]<{ivr}	0.0010000000000682009	0.005984923803525735
B[Na.LP_1...]<{ivr}	0.12225842138343852	0.9820137900379085
ssB[Na.LP_1...]<{ivr}	2.031685455019141E-9	0.9904426836915081
tB[Na.LP_1...]<{ivr}	0.005001114639586162	0.019156542394554353
IVDxREG[Na.LP_1...]<{ivr}	-123.5735794611175	-1.6216455674961905E-4
Ivd[K.LP_1...]<{ivr}	2.9043388283675895E-6	122.97193483519506
pGBI[K.LP_1...]<{ivr}	1.0	1.0
pGBS[K.LP_1...]<{ivr}	1.0	1.0
Gvd[K.LP_1...]<{ivr}	5.808677656735179E-7	2.0797727453265136
A[K.LP_1...]<{ivr}	0.01160731644530463	0.5049129110082909
ssA[K.LP_1...]<{ivr}	0.00815877129254967	0.9998632048157402
tA[K.LP_1...]<{ivr}	0.008107310854112334	0.07978705436006464
IVDxREG[K.LP_1...]<{ivr}	2.9043388283675895E-6	122.97193483519506
Ivd[leak.LP_1...]<{ivr}	-0.3204225158218506	12.007200056469443
pGBI[leak.LP_1...]<{ivr}	1.0	1.0
pGBS[leak.LP_1...]<{ivr}	1.0	1.0
Gvd[leak.LP_1...]<{ivr}	0.1	0.1
IVDxREG[leak.LP_1...]<{ivr}	-0.3204225158218506	12.007200056469443
V[LP_2....]<{ivr}	-78.2042251582185	45.07200056469444
sIex[LP_2....]<{ivr}	0.0	0.0
sIlight[LP_2....]<{ivr}	0.0	0.0
slightOn[LP_2....]<{ivr}	0.0	0.0
sIvd_reg[LP_2....]<{ivr}	-52.37654632517759	8.842121821623682
sIld[LP_2....]<{ivr}	0.0	0.0
sIcs[LP_2....]<{ivr}	-4.9593299822605905	1.795635692404105
sIes[LP_2....]<{ivr}	0.0	0.0
spk[LP_2....]<{ivr}	0.0	1.0
spknow[LP_2....]<{ivr}	0.0	1.0
tfin_spk[LP_2....]<{ivr}	0.0	1.0075450000023471
TR[GLU.LP_2...]<{ivr}	1.0	1.2470229558718462
ssTR[GLU.LP_2...]<{ivr}	1.0	1.0
pTBI[GLU.LP_2...]<{ivr}	1.0	1.0
pTBS[GLU.LP_2...]<{ivr}	1.0	1.0
Ivd[Na.LP_2...]<{ivr}	-123.5735794611175	-1.6216455674961905E-4
pGBI[Na.LP_2...]<{ivr}	1.0	1.0
pGBS[Na.LP_2...]<{ivr}	1.0	1.0
Gvd[Na.LP_2...]<{ivr}	1.297316577527477E-6	3.5504504092626825
A[Na.LP_2...]<{ivr}	0.005486298899450404	0.9990317833584326
ssA[Na.LP_2...]<{ivr}	0.002897963002087032	0.9999999932545667
tA[Na.LP_2...]<{ivr}	0.0010000000000682009	0.005984923803525735
B[Na.LP_2...]<{ivr}	0.12225842138343852	0.9820137900379085
ssB[Na.LP_2...]<{ivr}	2.031685455019141E-9	0.9904426836915081
tB[Na.LP_2...]<{ivr}	0.005001114639586162	0.019156542394554353
IVDxREG[Na.LP_2...]<{ivr}	-123.5735794611175	-1.6216455674961905E-4
Ivd[K.LP_2...]<{ivr}	2.9043388283675895E-6	122.97193483519506
pGBI[K.LP_2...]<{ivr}	1.0	1.0
pGBS[K.LP_2...]<{ivr}	1.0	1.0
Gvd[K.LP_2...]<{ivr}	5.808677656735179E-7	2.0797727453265136
A[K.LP_2...]<{ivr}	0.01160731644530463	0.5049129110082909
ssA[K.LP_2...]<{ivr}	0.00815877129254967	0.9998632048157402
tA[K.LP_2...]<{ivr}	0.008107310854112334	0.07978705436006464
IVDxREG[K.LP_2...]<{ivr}	2.9043388283675895E-6	122.97193483519506
Ivd[leak.LP_2...]<{ivr}	-0.3204225158218506	12.007200056469443
pGBI[leak.LP_2...]<{ivr}	1.0	1.0
pGBS[leak.LP_2...]<{ivr}	1.0	1.0
Gvd[leak.LP_2...]<{ivr}	0.1	0.1
IVDxREG[leak.LP_2...]<{ivr}	-0.3204225158218506	12.007200056469443
Ics[MN.>----.SN_1.exc.]<{ivr}	-1.2960214304765976	0.3482672754775954
Gcs[MN.>----.SN_1.exc.]<{ivr}	0.0	0.015932110189872044
fAt[MN.>----.SN_1.exc.]<{ivr}	0.0	0.0569003935352573
At[MN.>----.SN_1.exc.]<{ivr}	0.0	0.0569003935352573
Xt[MN.>----.SN_1.exc.]<{ivr}	0.0	0.9995001249791693
PSM[MN.>----.SN_1.exc.]<{ivr}	0.17098080931294832	1.0
Ics[MN.>----.SN_2.exc.]<{ivr}	-1.3028490785717304	0.34812800338995287
Gcs[MN.>----.SN_2.exc.]<{ivr}	0.0	0.015953446959831603
fAt[MN.>----.SN_2.exc.]<{ivr}	0.0	0.05697659628511286
At[MN.>----.SN_2.exc.]<{ivr}	0.0	0.05697659628511286
Xt[MN.>----.SN_2.exc.]<{ivr}	0.0	0.9995001249791693
PSM[MN.>----.SN_2.exc.]<{ivr}	0.17033067376669347	1.0
Ics[MN.>----.SN_3.exc.]<{ivr}	-1.3095960615009294	0.3480235858752235
Gcs[MN.>----.SN_3.exc.]<{ivr}	0.0	0.015974432039340042
fAt[MN.>----.SN_3.exc.]<{ivr}	0.0	0.057051542997643
At[MN.>----.SN_3.exc.]<{ivr}	0.0	0.057051542997643
Xt[MN.>----.SN_3.exc.]<{ivr}	0.0	0.9995001249791693
PSM[MN.>----.SN_3.exc.]<{ivr}	0.16969241768962787	1.0
Ics[MN.>----.SN_4.exc.]<{ivr}	-1.3165049927374075	0.34791919967948387
Gcs[MN.>----.SN_4.exc.]<{ivr}	0.0	0.015995978313696462
fAt[MN.>----.SN_4.exc.]<{ivr}	0.0	0.057128493977487364
At[MN.>----.SN_4.exc.]<{ivr}	0.0	0.057128493977487364
Xt[MN.>----.SN_4.exc.]<{ivr}	0.0	0.9995001249791693
PSM[MN.>----.SN_4.exc.]<{ivr}	0.1690548162189824	1.0
Ics[LP_1.>----.SN_1.exc.]<{ivr}	-1.2461451969206458	0.4491446196318667
Gcs[LP_1.>----.SN_1.exc.]<{ivr}	0.0	0.015932110189872044
fAt[LP_1.>----.SN_1.exc.]<{ivr}	0.0	0.0569003935352573
At[LP_1.>----.SN_1.exc.]<{ivr}	0.0	0.0569003935352573
Xt[LP_1.>----.SN_1.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_1.>----.SN_1.exc.]<{ivr}	0.17098080931294832	1.0
Ics[LP_1.>----.SN_2.exc.]<{ivr}	-1.2560661084961662	0.4489650066930862
Gcs[LP_1.>----.SN_2.exc.]<{ivr}	0.0	0.015953446959831603
fAt[LP_1.>----.SN_2.exc.]<{ivr}	0.0	0.05697659628511286
At[LP_1.>----.SN_2.exc.]<{ivr}	0.0	0.05697659628511286
Xt[LP_1.>----.SN_2.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_1.>----.SN_2.exc.]<{ivr}	0.17033067376669347	1.0
Ics[LP_1.>----.SN_3.exc.]<{ivr}	-1.2666871943751559	0.44883034412718265
Gcs[LP_1.>----.SN_3.exc.]<{ivr}	0.0	0.015974432039340042
fAt[LP_1.>----.SN_3.exc.]<{ivr}	0.0	0.057051542997643
At[LP_1.>----.SN_3.exc.]<{ivr}	0.0	0.057051542997643
Xt[LP_1.>----.SN_3.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_1.>----.SN_3.exc.]<{ivr}	0.16969241768962787	1.0
Ics[LP_1.>----.SN_4.exc.]<{ivr}	-1.2782529902343525	0.44869572195196966
Gcs[LP_1.>----.SN_4.exc.]<{ivr}	0.0	0.015995978313696462
fAt[LP_1.>----.SN_4.exc.]<{ivr}	0.0	0.057128493977487364
At[LP_1.>----.SN_4.exc.]<{ivr}	0.0	0.057128493977487364
Xt[LP_1.>----.SN_4.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_1.>----.SN_4.exc.]<{ivr}	0.1690548162189824	1.0
Ics[LP_2.>----.SN_1.exc.]<{ivr}	-1.2461451969206458	0.4491446196318667
Gcs[LP_2.>----.SN_1.exc.]<{ivr}	0.0	0.015932110189872044
fAt[LP_2.>----.SN_1.exc.]<{ivr}	0.0	0.0569003935352573
At[LP_2.>----.SN_1.exc.]<{ivr}	0.0	0.0569003935352573
Xt[LP_2.>----.SN_1.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_2.>----.SN_1.exc.]<{ivr}	0.17098080931294832	1.0
Ics[LP_2.>----.SN_2.exc.]<{ivr}	-1.2560661084961662	0.4489650066930862
Gcs[LP_2.>----.SN_2.exc.]<{ivr}	0.0	0.015953446959831603
fAt[LP_2.>----.SN_2.exc.]<{ivr}	0.0	0.05697659628511286
At[LP_2.>----.SN_2.exc.]<{ivr}	0.0	0.05697659628511286
Xt[LP_2.>----.SN_2.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_2.>----.SN_2.exc.]<{ivr}	0.17033067376669347	1.0
Ics[LP_2.>----.SN_3.exc.]<{ivr}	-1.2666871943751559	0.44883034412718265
Gcs[LP_2.>----.SN_3.exc.]<{ivr}	0.0	0.015974432039340042
fAt[LP_2.>----.SN_3.exc.]<{ivr}	0.0	0.057051542997643
At[LP_2.>----.SN_3.exc.]<{ivr}	0.0	0.057051542997643
Xt[LP_2.>----.SN_3.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_2.>----.SN_3.exc.]<{ivr}	0.16969241768962787	1.0
Ics[LP_2.>----.SN_4.exc.]<{ivr}	-1.2782529902343525	0.44869572195196966
Gcs[LP_2.>----.SN_4.exc.]<{ivr}	0.0	0.015995978313696462
fAt[LP_2.>----.SN_4.exc.]<{ivr}	0.0	0.057128493977487364
At[LP_2.>----.SN_4.exc.]<{ivr}	0.0	0.057128493977487364
Xt[LP_2.>----.SN_4.exc.]<{ivr}	0.0	0.9995001249791693
PSM[LP_2.>----.SN_4.exc.]<{ivr}	0.1690548162189824	1.0
Ics[MN.>----.LP_1.excS.]<{ivr}	0.08292627783875137	2.025966583559368
Gcs[MN.>----.LP_1.excS.]<{ivr}	0.002583984260295164	0.0135
fAt[MN.>----.LP_1.excS.]<{ivr}	0.19140624150334548	1.0
At[MN.>----.LP_1.excS.]<{ivr}	0.0	0.008448980055674115
Xt[MN.>----.LP_1.excS.]<{ivr}	0.0	1.0
PSM[MN.>----.LP_1.excS.]<{ivr}	0.0	0.0
Ics[MN.>----.LP_2.excS.]<{ivr}	0.08292627783875137	2.025966583559368
Gcs[MN.>----.LP_2.excS.]<{ivr}	0.002583984260295164	0.0135
fAt[MN.>----.LP_2.excS.]<{ivr}	0.19140624150334548	1.0
At[MN.>----.LP_2.excS.]<{ivr}	0.0	0.008448980055674115
Xt[MN.>----.LP_2.excS.]<{ivr}	0.0	1.0
PSM[MN.>----.LP_2.excS.]<{ivr}	0.0	0.0
Ics[MN.>----.LP_1.excF.]<{ivr}	-0.7592071080686844	0.2295690837089995
Gcs[MN.>----.LP_1.excF.]<{ivr}	0.0	0.009111867118148475
fAt[MN.>----.LP_1.excF.]<{ivr}	0.0	0.06508476512963196
At[MN.>----.LP_1.excF.]<{ivr}	0.0	0.06508476512963196
Xt[MN.>----.LP_1.excF.]<{ivr}	0.0	1.0
PSM[MN.>----.LP_1.excF.]<{ivr}	0.0	0.0
Ics[MN.>----.LP_2.excF.]<{ivr}	-0.7592071080686844	0.2295690837089995
Gcs[MN.>----.LP_2.excF.]<{ivr}	0.0	0.009111867118148475
fAt[MN.>----.LP_2.excF.]<{ivr}	0.0	0.06508476512963196
At[MN.>----.LP_2.excF.]<{ivr}	0.0	0.06508476512963196
Xt[MN.>----.LP_2.excF.]<{ivr}	0.0	1.0
PSM[MN.>----.LP_2.excF.]<{ivr}	0.0	0.0

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