A theory of ongoing activity in V1 (Goldberg et al 2004)

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Accession:83570
Ongoing spontaneous activity in the cerebral cortex exhibits complex spatiotemporal patterns in the absence of sensory stimuli. To elucidate the nature of this ongoing activity, we present a theoretical treatment of two contrasting scenarios of cortical dynamics: (1) fluctuations about a single background state and (2) wandering among multiple “attractor” states, which encode a single or several stimulus features. Studying simplified network rate models of the primary visual cortex (V1), we show that the single state scenario is characterized by fast and high-dimensional Gaussian-like fluctuations, whereas in the multiple state scenario the fluctuations are slow, low dimensional, and highly non-Gaussian. Studying a more realistic model that incorporates correlations in the feedforward input, spatially restricted cortical interactions, and an experimentally derived layout of pinwheels, we show that recent optical-imaging data of ongoing activity in V1 are consistent with the presence of either a single background state or multiple attractor states encoding many features.
Reference:
1 . Goldberg JA, Rokni U, Sompolinsky H (2004) Patterns of ongoing activity and the functional architecture of the primary visual cortex. Neuron 42:489-500 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Connectionist Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Spatio-temporal Activity Patterns; Rate-coding model neurons;
Implementer(s): Goldberg, Joshua [JoshG at ekmd.huji.ac.il];
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goldbergEtAl2004
readme.txt
CosIntCol20.tab
NoisyRing.ode
                            
This is the readme.txt for a model associated with the publication:

Goldberg JA, Rokni U, Sompolinsky H (2004) Patterns of ongoing
activity and the functional architecture of the primary visual
cortex. Neuron 42:489-500

Notes from Josh Goldberg:

This model is at the heart of our 2004 Neuron paper. It is analyzed in
and about figure 3 in that paper. The initial code was run in Matlab
and the paper includes a variety of models that elaborate on this
model.... I do believe that this is the most elegant/central part of
the paper.

Usage notes:

To run the .tab file must be in the same directory as the .ode file.
... run the program as usual in the main XPP window, that is: I,G.
Then once you fill in the the entries in the Edit Arrayplot Window
(see the begining of NoisyRing.ode), you must press "redraw". then
each time you continue the integration in the main XPP window (e.g.,
E,I,L) do "redraw" again and see the continuation of the
simulation.

The model has three states, homogeneous for low gains (lambda<1) and
then Marginal for lambda that is between 1 and 2 (for mu>0). (the
integration diverges for lambda larger than 2). this is all explained
in the paper. Marginal means that you get a noisy hill of activity.  I
think it is important to point out that this model corresponds only to
figure 3 in that paper.

Default values lambda=1.8 and mu=1 give a nice hill of activity with
some of the neurons with rates that are very close to zero. (The
spatial pattern on the ring is a noisy clipped sinusoid).

Finally the line

aux phiang=atan(rfunds/rfundc)

gives the phase of the order parameter (between -pi and pi) and it 
corresponds to the position of the center of the hill of activity along 
the ring. It is well defined when there is a nice hill, as in the case 
of the above default values of lambda and mu.

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