Differential modulation of pattern and rate in a dopamine neuron model (Canavier and Landry 2006)

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Accession:84612
"A stylized, symmetric, compartmental model of a dopamine neuron in vivo shows how rate and pattern can be modulated either concurrently or differentially. If two or more parameters in the model are varied concurrently, the baseline firing rate and the extent of bursting become decorrelated, which provides an explanation for the lack of a tight correlation in vivo and is consistent with some independence of the mechanisms that generate baseline firing rates versus bursting. ..." See paper for more and details.
Reference:
1 . Canavier CC, Landry RS (2006) An increase in AMPA and a decrease in SK conductance increase burst firing by different mechanisms in a model of a dopamine neuron in vivo. J Neurophysiol 96:2549-63 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Substantia nigra pars compacta DA cell;
Channel(s): I L high threshold; I N; I T low threshold; I A; I K; I K,Ca; I Sodium; I Calcium; Na/K pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Detailed Neuronal Models; Intrinsic plasticity; Calcium dynamics; Sodium pump;
Implementer(s): Kuznetsova, Anna [anna.kuznetsova at utsa.edu];
Search NeuronDB for information about:  Substantia nigra pars compacta DA cell; AMPA; NMDA; Gaba; I L high threshold; I N; I T low threshold; I A; I K; I K,Ca; I Sodium; I Calcium; Na/K pump;
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CanavierLandry2006
in_vitro
ampa.mod
cabalan.mod *
cachan.mod *
capump.mod *
hh3.mod *
kca.mod *
leak.mod *
nabalan.mod *
nmdaL.mod
pump.mod *
stim.mod *
fig4a.hoc
fig4a1.hoc
fig4a1.ses
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fig4a3.ses
                            
TITLE applied current

COMMENT
Since this is an electrode current, positive values of i depolarize
the cell and in the presence of the extracellular mechanism there will be a
change in vext since i is not a transmembrane current but a current injected
directly to the inside of the cell.
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	POINT_PROCESS MyIClamp
	RANGE del,dur,amp,amp2,i
	ELECTRODE_CURRENT i
}
UNITS {
	(nA) = (nanoamp)
}

PARAMETER {
	del  (ms)
	dur  (ms)	<0,1e9>
	amp  (nA)
	amp2 (nA)
}
ASSIGNED { i (nA) }

INITIAL {
	i = amp
}

BREAKPOINT {
	at_time(del)
	at_time(del+dur)

	if (t < del + dur && t > del) {
		i = amp +amp2
	}else{
		i = amp
	}
}

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