CA1 oriens alveus interneurons: signaling properties (Minneci et al. 2007)

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Accession:87546
The model supports the experimental findings showing that the dynamic interaction between cells with various firing patterns could differently affect GABAergic signaling, leading to a wide range of interneuronal communication within the hippocampal network.
Reference:
1 . Minneci F, Janahmadi M, Migliore M, Dragicevic N, Avossa D, Cherubini E (2007) Signaling properties of stratum oriens interneurons in the hippocampus of transgenic mice expressing EGFP in a subset of somatostatin-containing cells. Hippocampus 17:538-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 interneuron oriens alveus GABA cell;
Channel(s): I A; I Sodium; I Potassium;
Gap Junctions: Gap junctions;
Receptor(s): Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Active Dendrites; Detailed Neuronal Models; Action Potentials; Signaling pathways;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 interneuron oriens alveus GABA cell; Gaba; I A; I Sodium; I Potassium;
TITLE K slow channel from Wang (2002)
: M.Migliore Dec. 2003

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v (mV)
	celsius		(degC)
	gksbar=.005 (mho/cm2)
	q10=2
	ek
	a0q=100
	tvh=50
	vhalfp=-35
	vhalfq=-50
	kp=2
	kq=6.6
	tk=6.8
	to=10
	tp=6
}


NEURON {
	SUFFIX ks
	USEION k READ ek WRITE ik
        RANGE gksbar,gks
        GLOBAL pinf,qinf,taup,tauq
}

STATE {
	p
	q
}

ASSIGNED {
	ik (mA/cm2)
        pinf
        qinf      
        taup
        tauq
        gks
}

INITIAL {
	rates(v)
	p=pinf
	q=qinf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	gks = gksbar*p*q
	ik = gks*(v-ek)

}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rates(v)
        p' = (pinf - p)/taup
        q' = (qinf - q)/tauq
}

PROCEDURE rates(v (mV)) { :callable from hoc
        LOCAL qt
        qt=q10^((celsius-25)/10)
        pinf = (1/(1+ exp(-(v-vhalfp)/kp)))
        qinf = (1/(1+ exp((v-vhalfq)/kq)))
	taup = tp/qt
	tauq = to + a0q/(1+exp(-(v+tvh)/tk))/qt
}

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