Rod photoreceptor (Barnes and Hille 1989, Publio et al. 2006, Kourennyi and Liu et al. 2004)

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Accession:95870
This a conductance-based model of a rod photoreceptor cell based on other modeling works (Barnes and Hille 1989 and Publio et al. 2006 and Kourennyi and Liu et al. 2004 ). In this model four types of ionic channels identified in the inner segment of the rod: nonselective cation channel (h), delayed rectifying potassium channel (Kv), noninactivating potassium channel (Kx) and calcium channel (Ca) was used. The model accurately reproduces the rod response when stimulated with a simulated photocurrent signal. We can show the effect of nonselective cation channel. The absence of this channel cause increasing the peak amplitude and the time to reach the peak of voltage response and absence of transient mode in this response.
References:
1 . Barnes S, Hille B (1989) Ionic channels of the inner segment of tiger salamander cone photoreceptors. J Gen Physiol 94:719-43 [PubMed]
2 . Kourennyi DE, Liu XD, Hart J, Mahmud F, Baldridge WH, Barnes S (2004) Reciprocal modulation of calcium dynamics at rod and cone photoreceptor synapses by nitric oxide. J Neurophysiol 92:477-83 [PubMed]
3 . Liu XD, Kourennyi DE (2004) Effects of tetraethylammonium on Kx channels and simulated light response in rod photoreceptors. Ann Biomed Eng 32:1428-42 [PubMed]
4 . Publio R, Oliveira RF, Roque AC (2006) A realistic model of rod photoreceptor for use in a retina network model Neurocomputing 69:1020-1024
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Retina photoreceptor cone GLU cell;
Channel(s): I Cl,Ca; I K,Ca; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Calcium dynamics;
Implementer(s): Shahali, Mahboubeh [shahali222 at yahoo.com];
Search NeuronDB for information about:  Retina photoreceptor cone GLU cell; I Cl,Ca; I K,Ca; I Calcium; I Potassium;
//comparing two rods,first rod have nonselective cation channel (h),but second one does not.
load_file("nrngui.hoc")
load_proc ("nrnmainmenu")
create rod1,rod2
access rod1
rod1{//with nonselective cation channel (h)

 nseg=1
 diam=10  //um
 L=10/PI  //um
 cm=30  // 1uF/cm2
 insert Kv
 insert hyper
 insert Kx
 insert Leak
 insert Ca
 insert Cad
 insert CPR
 }
access rod2
rod2{//without nonselective cation channel (h)
 nseg=1
 diam=10  //um
 L=10/PI  //um
 cm=30  // 1uF/cm2
 insert Kv
 insert Kx
 insert Leak
 insert Ca
 insert Cad
 insert CPR
 }


objectvar stimulation1
rod1 stimulation1= new IinjLT(0.5)
	stimulation1.amp  =100 
objectvar stimulation2
rod2 stimulation2= new IinjLT(0.5)
	stimulation2.amp  =100 

xopen("vv.ses")



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