Kinetics of the P2X7 receptor as expressed in Xenopus oocytes (Riedel et al. 2007a,b)

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Accession:95990
"Human P2X7 receptors were expressed in Xenopus laevis oocytes and single channels were recorded using the patch-clamp technique in the outside-out configuration. ATP4- evoked two types of P2X7 receptor-mediated single channel currents characterized by short-lived and long-lived openings. ... The kinetics of the short channel openings at negative membrane potentials fitted well to a linear C-C-C-O model with two ATP4- binding steps at equal binding sites ...." and "Using the patch-clamp method, we studied the influence of external alkali and organic monovalent cations on the single-channel properties of the adenosine triphosphate (ATP)-activated recombinant human P2X(7) receptor." See the references for more.
References:
1 . Riedel T, Schmalzing G, Markwardt F (2007) Influence of Extracellular Monovalent Cations on Pore and Gating Properties of P2X7 Receptor-Operated Single-Channel Currents. Biophys J 93:846-58 [PubMed]
2 . Riedel T, Lozinsky I, Schmalzing G, Markwardt F (2007) Kinetics of P2X7 receptor-operated single channels currents. Biophys J 92:2377-91 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Microglia; Macrophage; B lymphocyte;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: QuB;
Model Concept(s): Ion Channel Kinetics; Nociception;
Implementer(s):
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