Vesicular pool simulations of synaptic depression (Aristizabal and Glavinovic 2004)

 Download zip file 
Help downloading and running models
Accession:97274
"Synaptic release was simulated using a Simulink sequential storage model with three vesicular pools. Modeling was modular and easily extendable to the systems with greater number of vesicular pools, parallel input, or time-varying parameters. ... Finally, the method was tested experimentally using the rat phrenic-diaphragm neuromuscular junction." See paper for more and details.
Reference:
1 . Aristizabal F, Glavinovic MI (2004) Simulation and parameter estimation of dynamics of synaptic depression. Biol Cybern 90:3-18 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB; Simulink;
Model Concept(s):
Implementer(s):
%Generate Stimulation Pulses
f1 = 20;        % first frequency
f2 = 10;         % second frequency
n = 12;          % number of cycles

sp = 1/max([f1, f2])/100;       % sampling period

t1 = 0:sp:1;
t2 = 1 + sp:sp:2;
y1 = abs(sin(pi*f1*t1));
y2 = abs(sin(pi*f2*t2));
y = [y1, y2];
t = [t1, t2];
y11 = [y == max(y)];

% concatenate n cycles
yy = [0];
y11(1) = [];
for c = 1: n
    yy = [yy, -y11];
end
ly = length(yy);
tt = linspace(0, 4*n, ly);

tu = [tt', yy'];

Loading data, please wait...