"Synaptic release was simulated using a Simulink sequential storage model with three vesicular pools. Modeling was modular and easily extendable to the systems with greater number of vesicular pools, parallel input, or time-varying parameters. ... Finally, the method was tested experimentally using the rat phrenic-diaphragm neuromuscular junction."
See paper for more and details.
Aristizabal F, Glavinovic MI (2004) Simulation and parameter estimation of dynamics of synaptic depression. Biol Cybern 90:3-18 [PubMed]