Determinants of fast calcium dynamics in dendritic spines and dendrites (Cornelisse et al. 2007)

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Accession:97903
"... Calcium influx time course and calcium extrusion rate were both in the same range for spines and dendrites when fitted with a dynamic multi-compartment model that included calcium binding kinetics and diffusion. In a subsequent analysis we used this model to investigate which parameters are critical determinants in spine calcium dynamics. The model confirmed the experimental findings: a higher SVR (surface-to-volume ratio) is not sufficient by itself to explain the faster rise time kinetics in spines, but only when paired with a lower buffer capacity in spines. Simulations at zero calcium-dye conditions show that calmodulin is more efficiently activated in spines, which indicates that spine morphology and buffering conditions in neocortical spines favor synaptic plasticity. ..."
Reference:
1 . Cornelisse LN, van Elburg RA, Meredith RM, Yuste R, Mansvelder HD (2007) High speed two-photon imaging of calcium dynamics in dendritic spines: consequences for spine calcium kinetics and buffer capacity. PLoS One 2:e1073 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: CalC Calcium Calculator;
Model Concept(s): Calcium dynamics;
Implementer(s): van Elburg, Ronald A.J. [R.van.Elburg at ai.rug.nl];
Search NeuronDB for information about:  Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
[Config]
Relative path=1
Compilator.SaveAll=0
Compilator.Capture=0
Compilator.HideOutput=0
DefaultCPIndex=0
LogtoEnd=1
DontOpen=0
FileFormat=0
[Project tree]
CaSims
	-SyntaxHighlighting
	+CalC Scripts
		+General
			CaSignal_main.par
			ZipFigures.bat
			Readme.txt
			runcalcscripts.sh
		+figure 3 Constrained Model
			CaSignal_Exp3Disc.par
			CaSignal_Exp3Sphere.par
		+figure 4 Endogenous Buffer and Geometry
			CaSignal_Exp4DSphere.par
			CaSignal_Exp4Disc.par
			CaSignal_Exp4DDisc.par
			CaSignal_Exp4Sphere.par
		+figure 8 Endogenous Mobile Buffers
			CaSignal_Exp8HbSphere.par
			CaSignal_Exp8HbDisc.par
			CaSignal_Exp8GbSphere.par
			CaSignal_Exp8GbDisc.par
			CaSignal_Exp8FSphere.par
			CaSignal_Exp8FDisc.par
			CaSignal_Exp8ESphere.par
			CaSignal_Exp8EDisc.par
			CaSignal_Exp8BSphere.par
			CaSignal_Exp8BDisc.par
			CaSignal_Exp8ASphere.par
			CaSignal_Exp8ADisc.par
		-figure SVREndoCalmod
			CaSignal_SVREndoCalmodDiscTraces.par
			CaSignal_SVREndoCalmodSphere.par
			CaSignal_SVREndoCalmodSphereTraces.par
			CaSignal_SVREndoCalmodDisc.par
		-figure SVREndo
			CaSignal_SVREndoDiscTraces.par
			CaSignal_SVREndoDisc.par
			CaSignal_SVREndoSphereTraces.par
			CaSignal_SVREndoSphere.par
		-figure XDiffKOn
			CaSignal_XDiffKOnSphere.par
			CaSignal_XDiffKOnDisc.par
			CaSignal_XDiffKOnSphereTraces.par
			CaSignal_XDiffKOnDiscTraces.par
		-figure KdEndo
			CaSignal_KdEndoSphere.par
			CaSignal_KdEndoDisc.par
			CaSignal_KdEndoSphereTraces.par
			CaSignal_KdEndoDiscTraces.par
		-figure DtGamma
			CaSignal_DtGammaSphereII.par
			CaSignal_DtGammaDiscII.par
			CaSignal_DtGammaSphere.par
			CaSignal_DtGammaDisc.par
		-figure KOnKOff
			CaSignal_KOnKOffSphere.par
			CaSignal_KOnKOffDisc.par
			CaSignal_KOnKOffDiscTraces.par
			CaSignal_KOnKOffSphereTraces.par
		-MatlabScripts
			-Auxilary
				-GraphicsSupport
					MatlabScripts\Graphics\swapfigures.m
					MatlabScripts\Graphics\RedistributeSubplots.m
					MatlabScripts\Graphics\ScaleBar.m
				-Functions
			MatlabScripts\XDiffKOn_MergedAtomics.m
			MatlabScripts\SVREndoCalmod_MergedAtomics.m
			MatlabScripts\SVREndo_MergedAtomics.m
			MatlabScripts\KOnKOff_MergedAtomics.m
			MatlabScripts\KdEndo_MergedAtomics.m
			MatlabScripts\FreeCalcium4EndoBufs_MergedAtomics.m
			MatlabScripts\EndoKd_MergedAtomics.m
			MatlabScripts\DtGammaII_MergedAtomics.m
			MatlabScripts\DtGamma_MergedAtomics.m
			MatlabScripts\CaSignal_XDiffKOnTraces.m
			MatlabScripts\CaSignal_XDiffKOn.m
			MatlabScripts\CaSignal_SVREndoTraces.m
			MatlabScripts\CaSignal_SVREndoCalmodTraces.m
			MatlabScripts\CaSignal_SVREndoCalmodCa.m
			MatlabScripts\CaSignal_SVREndoCalmod.m
			MatlabScripts\CaSignal_SVREndo.m
			MatlabScripts\CaSignal_PreProcessDataSecondVarIsDyeTotal.m
			MatlabScripts\CaSignal_PreProcessDataCa12.m
			MatlabScripts\CaSignal_PreProcessData.m
			MatlabScripts\CaSignal_PreProcessData12.m
			MatlabScripts\CaSignal_Master.m
			MatlabScripts\CaSignal_MakeFigures.m
			MatlabScripts\CaSignal_MakeFigures12.m
			MatlabScripts\CaSignal_MakeContourFigures.m
			MatlabScripts\CaSignal_MakeContourFigures12.m
			MatlabScripts\CaSignal_MakeBarFigures.m
			MatlabScripts\CaSignal_Make2DFigures.m
			MatlabScripts\CaSignal_Make2DFigures12.m
			MatlabScripts\CaSignal_KOnKOffTraces.m
			MatlabScripts\CaSignal_KOnKOff.m
			MatlabScripts\CaSignal_KdEndoTraces.m
			MatlabScripts\CaSignal_KdEndo.m
			MatlabScripts\CaSignal_ExpMain.m
			MatlabScripts\CaSignal_ExpMain12Ca.m
			MatlabScripts\CaSignal_ExpMain12b.m
			MatlabScripts\CaSignal_ExpMain12.m
			MatlabScripts\CaSignal_ExpB8.m
			MatlabScripts\CaSignal_Exp8Gb.m
			MatlabScripts\CaSignal_Exp8G.m
			MatlabScripts\CaSignal_Exp8A.m
			MatlabScripts\CaSignal_Exp8A2.m
			MatlabScripts\CaSignal_Exp8.m
			MatlabScripts\CaSignal_Exp7C.m
			MatlabScripts\CaSignal_Exp7A.m
			MatlabScripts\CaSignal_Exp4D.m
			MatlabScripts\CaSignal_Exp3Sub8.m
			MatlabScripts\CaSignal_Exp3Sub6.m
			MatlabScripts\CaSignal_Exp3Sub4.m
			MatlabScripts\CaSignal_Exp3Sub3.m
			MatlabScripts\CaSignal_Exp3Sub2.m
			MatlabScripts\CaSignal_Exp3Sub1.m
			MatlabScripts\CaSignal_Exp3.m
			MatlabScripts\CaSignal_DtGammaII.m
			MatlabScripts\CaSignal_DtGamma.m
[Open project files]
0=Readme.txt
1=CaSignal_main.par
2=runcalcscripts.sh
3=MatlabScripts\CaSignal_Master.m
4=ZipFigures.bat
[Selected Project Files]
Main=
Selected=Readme.txt
[Readme.txt]
TopLine=21
Caret=45,55
[CaSignal_main.par]
TopLine=70
Caret=1,1
[runcalcscripts.sh]
TopLine=25
Caret=1,19
[MatlabScripts\CaSignal_Master.m]
TopLine=1
Caret=1,1
[ZipFigures.bat]
TopLine=1
Caret=1,1

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