Myelinated axon conduction velocity (Brill et al 1977)

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Accession:9848
Examines conduction velocity as function of internodal length.
Reference:
1 . Brill MH, Waxman SG, Moore JW, Joyner RW (1977) Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. J Neurol Neurosurg Psychiatry 40:769-74 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  I Na,t; I K;
Brill, Waxman, Moore, and Joyner (1977) Conduction velocity and spike
configuration in myelinated fibres: Computed dependence on internode distance
J. Neurology, Neurosurgery, and Psychiatry. 40: 769-774

This model reproduces figures 1 and 2. On launch it simulates fig 2b.
Note that the myelin locations for voltage plots for fig 2b differ from the
paper by half a segment length. That is, in the paper the locations are at
x=.1, .2, .3, ..., .9 whereas in this simulation the centers of the 10 myelin
segments are at x = .05, .15, .25, ..., .95

The NEURON implementation of this model was prepared by Michael Hines.
Questions about details of this implementation should be addressed to him
at michael.hines@yale.edu.


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