Site of impulse initiation in a neuron (Moore et al 1983)

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Accession:9852
Examines the effect of temperature, the taper of the axon hillock, and HH channel density on antidromic spike invasion into the soma and spike initiation under dendritic stimulation.
Reference:
1 . Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord motor neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Simplified Models;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Spinal cord motor neuron; I Na,t; I K;
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moore83
README
init.hoc
mosinit.hoc
start.ses
                            
Moore, Stockbridge, and Westerfield. (1983) On the site of impulse initiation
in a neurone. 
J. Physiol. 336: 301-311.

This model qualitatively reproduces figures 1-5.
Note that orthodromic stimulus amplitude is considerably different from
that noted in the paper. IClamp[0].amp was chosen to give qualitative similarity.
We attribute minor quantitative differences to the following:
1) The precise site of axon v vs t curve is not specified. We plot
axon.v(0.25).
2) The antidromic stimulus was unspecified.


The NEURON implementation of this model was prepared by Michael Hines.
Questions about details of this implementation should be addressed to him
at michael.hines@yale.edu.


Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11[PubMed]

References and models cited by this paper

References and models that cite this paper

Brill MH, Waxman SG, Moore JW, Joyner RW (1977) Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. J Neurol Neurosurg Psychiatry 40:769-74 [PubMed]

   Myelinated axon conduction velocity (Brill et al 1977) [Model]

Burke RE, Rudomin P (1977) Spinal neurons and synapses. Handbook of Physiology, The nervous system, Section 1, Kandel ER, ed. pp.877

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Frank K, Fuortes MGF (1957) Presynaptic and postsynaptic inhibition of monosynaptic reflexes. Fed Proc 16:39-40

Frank K, Fuortes MGF, Nelson PG (1959) Voltage clamp of motoneuron soma Science, N Y 130:38-39

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   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

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Moore JW, Joyner RW, Brill MH, Waxman SD, Najar-Joa M (1978) Simulations of conduction in uniform myelinated fibers. Relative sensitivity to changes in nodal and internodal parameters. Biophys J 21:147-60 [Journal] [PubMed]

   Conduction in uniform myelinated axons (Moore et al 1978) [Model]

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   Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]

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   [1 reconstructed morphology on NeuroMorpho.Org]
   Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008) [Model]

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(30 refs)