Site of impulse initiation in a neuron (Moore et al 1983)

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Accession:9852
Examines the effect of temperature, the taper of the axon hillock, and HH channel density on antidromic spike invasion into the soma and spike initiation under dendritic stimulation.
Reference:
1 . Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Simplified Models;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,t; I K;
/
moore83
README
init.hoc
mosinit.hoc
start.ses
                            
load_file("nrngui.hoc")
load_file("start.ses")

// add a 3-d point at 150 um in axon to allow taper from 0 to 150 if needed
// the cell builder only constructs 2 point 3d sections.
axon { pt3dinsert(1, .9*x3d(0)+.1*x3d(1), .9*y3d(0)+.1*y3d(1), 0, 10) }

proc prun() { // normal run but keep lines every .1 ms on shape plot
	stdinit()
	Graph[1].erase()
	while (t < tstop) {
		continuerun(t + .1)
		if (stoprun) break
		Graph[1].exec_menu("Keep Lines")
		Graph[1].exec_menu("Keep Lines")
	}
}

// undo any figure changes
proc standard() {
	tstop = 3
	tstop_changed()
	celsius = 16.3
	axon.diam=10
	forall { gnabar_hh = .12  gkbar_hh = .036  gl_hh = .0003 }
	dend {
		gnabar_hh = 0  gkbar_hh = 0  gl_hh = 0
		g_pas = 1/6000
	}
	axon { stimdef(1, .1, 20) }
}

proc stimdef() {
	hoc_ac_ = $1
	PointProcessManager[0].move()
	PointProcessManager[0].pp.dur = $2
	PointProcessManager[0].pp.amp = $3
}

proc taper() {
	axon {pt3dchange(0, soma.diam)}
	// since the next 2d point is at 150 microns this will result in
	// a taper
}

proc extrahh() {local x
	dend {
		x = $1/L
		g_pas(0:x) = 0:0
		gnabar_hh(0:x) = .12:.12
		gkbar_hh(0:x) = .036:.036
		gl_hh(0:x) = .0003:.0003
	}
}


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