Site of impulse initiation in a neuron (Moore et al 1983)

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Accession:9852
Examines the effect of temperature, the taper of the axon hillock, and HH channel density on antidromic spike invasion into the soma and spike initiation under dendritic stimulation.
Reference:
1 . Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Simplified Models;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,t; I K;
/
moore83
README
init.hoc
mosinit.hoc
start.ses
                            
load_file("nrngui.hoc")
load_file("init.hoc")
secondorder=2

strdef figstr

proc fig1a() {
	figstr="1A : standard parameter set"
	standard()
	prun()
}
proc fig1b() {
	figstr="1B : cool to 6.3 DegC"
	standard()
	tstop = 5 tstop_changed()
	celsius = 6.3
	prun()
}
proc fig1c() {
	figstr="1C : taper axon hillock"
	standard()
	taper()
	prun()
}
proc fig1d() {
	figstr="1D : extend HH in dendrite"
	standard()
	extrahh(100)
	prun()
}

fig1a()

xpanel("Figures")
xvarlabel(figstr)
//xmenu("Fig 1")
xbutton("Figure 1A", "fig1a()")
xbutton("Figure 1B", "fig1b()")
xbutton("Figure 1C", "fig1c()")
xbutton("Figure 1D", "fig1d()")
//xmenu()
//xmenu("Figure 2")
xbutton("Figure 2A", "fig2a()")
xbutton("Figure 2B", "fig2b()")
//xmenu()
//xmenu("Fig 3")
xbutton("Figure 3A", "fig3a()")
xbutton("Figure 3B", "fig3b()")
xbutton("Figure 3C", "fig3c()")
//xmenu()
//xmenu("Fig 4")
xbutton("Figure 4A", "fig4a()")
xbutton("Figure 4B", "fig4b()")
xbutton("Figure 4C", "fig4c()")
//xmenu()
//xmenu("Fig 5")
xbutton("Figure 5A", "fig5a()")
xbutton("Figure 5B", "fig5b()")
xbutton("Figure 5C", "fig5c()")
xbutton("Figure 5D", "fig5d()")
xmenu()
xpanel(300,100)

proc fig2a() {
	figstr="2A :extend HH to 500um"
	standard()
	extrahh(500)
	prun()
}
proc fig2b() {
	figstr="2B :increase HH density 5-fold"
	standard()
	forall if (ismembrane("hh")) { gnabar_hh *= 5  gkbar_hh *= 5  gl_hh *= 5 }
	prun()
}
// paper states that 3c has amplitude of -0.15uA but at this location
// and duration, this model requires 700 nA
proc fig3a() {
	figstr="3A : HH throughout dendrite"
	standard()
	extrahh(dend.L)
	dend stimdef(2750/3400, .2, 700)
	prun()
}
proc fig3b() {
	figstr="3B : restrict HH to 300um in dendrite"
	standard()
	extrahh(300)
	dend stimdef(2750/3400, .2, 700)
	prun()
}
proc fig3c() {
	figstr="3C : no HH in dendrite"
	standard()
	dend stimdef(2750/3400, .2, 700)
	tstop = 5 tstop_changed()
	prun()
}
proc fig4a() {
	figstr="4A : stimulus amp=700 (not 150 nA)"
	standard()
	dend stimdef(2500/3400, .2, 700)
	tstop = 5 tstop_changed()
	prun()
}
proc fig4b() {
	figstr="4B : stimulus amp=625 (not 133.5 nA)"
	standard()
	dend stimdef(2500/3400, .2, 625)
	tstop = 5 tstop_changed()
	prun()
}
proc fig4c() {
	figstr="4C : stimulus amp=1400 (not 300 nA)"
	standard()
	dend stimdef(2500/3400, .2, 1400)
	tstop = 5 tstop_changed()
	prun()
}
proc fig5a() {
	figstr="5A : taper axon hillock"
	standard()
	taper()
	dend stimdef(2500/3400, .2, 700)
	prun()
}
proc fig5b() {
	figstr="5B : cool to 6.3 degC"
	standard()
	celsius=6.3
	dend stimdef(2500/3400, .2, 700)
	tstop = 5 tstop_changed()
	prun()
}
proc fig5c() {
	figstr="5C : 5*HH density"
	standard()
	forall if (ismembrane("hh")) { gnabar_hh *= 5  gkbar_hh *= 5  gl_hh *= 5 }
	dend stimdef(2500/3400, .2, 700)
	prun()
}
proc fig5d() {
	figstr="5D : soma stimulated, amp=105"
	standard()
	soma stimdef(.25, .2, 105)
	prun()
}


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