Site of impulse initiation in a neuron (Moore et al 1983)

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Accession:9852
Examines the effect of temperature, the taper of the axon hillock, and HH channel density on antidromic spike invasion into the soma and spike initiation under dendritic stimulation.
Reference:
1 . Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord motor neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Simplified Models;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Spinal cord motor neuron; I Na,t; I K;
/
moore83
README
init.hoc
mosinit.hoc
start.ses
                            
objectvar save_window_, rvp_
objectvar scene_vector_[6]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin CellBuild[0]
{
load_file("celbild.hoc", "CellBuild")
}
{ocbox_ = new CellBuild(1)}
{object_push(ocbox_)}
{
version(5.1)
continuous = 1
}
{object_push(topol)}
{
first = 0
slist.remove_all()
sname = "ax"
objref tobj
}
{
tobj = new CellBuildSection("soma",0, 0, tobj, 0) slist.append(tobj)
  tobj.position(0,0,15,0) tobj.lx=6.45351 tobj.ly=19.6453 tobj.i3d=0
tobj = new CellBuildSection("dend",0, 0, tobj, 0) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(0,0,-135,30) tobj.lx=-121.579 tobj.ly=15.0957 tobj.i3d=0
tobj = new CellBuildSection("axon",0, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(15,0,150,30) tobj.lx=135.638 tobj.ly=16.2474 tobj.i3d=0
all_init()
}
for i=0, slist.count-1 {slist.object(i).rdses()}
{object_pop()}
{
}
{object_push(subsets)}
{first = 0}
{tobj = new SNList("somden") snlist.append(tobj)}
for i=0,1 tobj.add(bild.topol.slist.object(fscan()))
0
1
{consist()}
{object_pop()}
{
}
{object_push(geom)}
{
first = 0
tobj = new GeoSpec(0)
tobj.value = 100
bild.topol.slist.object(0).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 50
bild.topol.slist.object(0).geo.append(tobj)
tobj = new GeoSpec(4)
tobj.value = 2
bild.topol.slist.object(0).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 3400
bild.topol.slist.object(1).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 50
bild.topol.slist.object(1).geo.append(tobj)
tobj = new GeoSpec(4)
tobj.value = 68
bild.topol.slist.object(1).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 1500
bild.topol.slist.object(2).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 10
bild.topol.slist.object(2).geo.append(tobj)
tobj = new GeoSpec(4)
tobj.value = 30
bild.topol.slist.object(2).geo.append(tobj)
set_default()
}
{object_pop()}
{
}
{object_push(memb)}
{first=0}
{
tobj = new GeoSpec(0)
tobj.value = 100
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new GeoSpec(1)
tobj.value = 1
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.12, 0)
tobj.set("gkbar_hh", 0.036, 0)
tobj.set("gl_hh", 0.0003, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("pas")
tobj.set("g_pas", 0.00016667, 0)
tobj.set("e_pas", -65, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0, 0)
tobj.set("gkbar_hh", 0, 0)
tobj.set("gl_hh", 0, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.12, 0)
tobj.set("gkbar_hh", 0.036, 0)
tobj.set("gl_hh", 0.0003, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(2).ml.append(tobj)
}
{object_pop()}
{
}
{object_push(manage)}
{
first = 0
classname = "Cell"
etop=1 esub=1 egeom=1 emem=1
itop=1 isub=0 igeom=0 imem=0
bild.topol.names_off = 0
bild.topol.circles_off = 0
}
{object_pop()}
{
cexport()
}
{object_pop()}
{
save_window_=ocbox_.gtopol
save_window_.size(-200,200,-150,150)
scene_vector_[2] = save_window_
ocbox_.gtopol = save_window_
save_window_.save_name("ocbox_.gtopol")
}
{
ocbox_.map("CellBuild[0]", 82, 121, 762.3, 256.5)
}
objref ocbox_
//End CellBuild[0]

{doNotify()}
{WindowMenu[0].ses_gid(1, 0, 0, "axon")}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
axon ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("IClamp") i = mt.selected()
ms[i] = new MechanismStandard("IClamp")
ms[i].set("del", 0, 0)
ms[i].set("dur", 0.1, 0)
ms[i].set("amp", 20, 0)
mt.select("IClamp") i = mt.selected() maction(i)
hoc_ac_ = 1
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 3, 532, 215.1, 376.2)
}
objref ocbox_
//End PointProcessManager

{
xpanel("RunControl", 0)
v_init = -65
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 0.1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 0
xvalue("t","t", 2 )
tstop = 3
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.01
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 100
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 0
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(2,100)
}
{
xpanel("Temperature", 0)
celsius = 16.3
xvalue("celsius","celsius", 1,"", 0, 1 )
xpanel(363,-1)
}
{
save_window_ = new Graph(0)
save_window_.size(-1000,1000,-80,40)
scene_vector_[4] = save_window_
{save_window_.view(-1000, -80, 2000, 120, 620, 358, 423, 265.6)}
flush_list.append(save_window_)
save_window_.save_name("flush_list.")
objectvar rvp_
rvp_ = new RangeVarPlot("v")
dend rvp_.begin(1)
axon rvp_.end(1)
rvp_.origin(0)
save_window_.addobject(rvp_, 1, 1, 0.8, 0.9)
}
{
save_window_ = new Graph(0)
save_window_.size(-2.98023e-08,3,-80,40)
scene_vector_[5] = save_window_
{save_window_.view(0, -80, 5, 120, 619, 0, 420.3, 214.3)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addvar("axon.v( 0.25 )", 1, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.v( 0.25 )", 2, 1, 0.8, 0.9, 2)
}
objectvar scene_vector_[1]
{doNotify()}

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