Thalamic quiescence of spike and wave seizures (Lytton et al 1997)

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Accession:9889
A phase plane analysis of a two cell interaction between a thalamocortical neuron (TC) and a thalamic reticularis neuron (RE).
Reference:
1 . Lytton WW, Contreras D, Destexhe A, Steriade M (1997) Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J Neurophysiol 77:1679-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Temporal Pattern Generation; Oscillations; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Glutamate; I T low threshold; Gaba; Glutamate;
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lytton97
README
AMPA.mod
calciumpump_destexhe.mod *
GABAB1.mod
GABALOW.mod
gen.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
nmda.mod
passiv.mod
presyn.mod *
pulse.mod *
rand.mod
boxes.hoc *
declist.hoc *
decvec.hoc *
default.hoc *
directory
fig7.gif
geom.hoc
grvec.hoc
init.hoc
jnphys77_1679.pdf
local.hoc *
mosinit.hoc
network.hoc
nrnoc.hoc *
params.hoc
presyn.inc *
queue.inc *
run.hoc
simctrl.hoc *
snshead.inc *
synq.inc *
xtmp
                            
NEURON {  POINT_PROCESS GABAB1 }
:   Simple synaptic mechanism derived for first order kinetics of
:   binding of transmitter to postsynaptic receptors.
:
:     GABA SYNAPSE (GABA-B receptors)
:
:     Parameters estimated from patch clamp recordings of GABAB PSP's in
:     rat hippocampal slices (Otis et al, J. Physiol. 463: 391-407, 1993)
:     and sharp electrode recordings in hippocampal pyramidal cells 
:     (Solis & Nicoll, J. Neurosci. 12: 3466-3472, 1992).  
:
:     To account for the time course of the GABAB IPSP with a first order
:     kinetics, it is assumed that the transmitter stays for 150 ms in the 
:     synaptic cleft.  This is very unrealistic, but it provides reasonable
:     summation of PSP's.
:
:   A. Destexhe , The Salk Institute, May 1993.
PARAMETER {
  Cmax    = 1     (mM)            : max transmitter concentration
  Cdur    = 150   (ms)            : transmitter duration (rising phase)
  Alpha   = 0.01  (/ms mM)        : forward (binding) rate
  Beta    = 0.005 (/ms)           : backward (unbinding) rate
  Erev    = -95   (mV)            : reversal potential (potassium)
  Prethresh = 0                   : voltage level nec for release
  Deadtime = 1    (ms)            : mimimum time between release events
  gmax            (umho)          : maximum conductance
}
INCLUDE "synq.inc"
:________________________________________________________________


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