Thalamic quiescence of spike and wave seizures (Lytton et al 1997)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:9889
A phase plane analysis of a two cell interaction between a thalamocortical neuron (TC) and a thalamic reticularis neuron (RE).
Reference:
1 . Lytton WW, Contreras D, Destexhe A, Steriade M (1997) Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J Neurophysiol 77:1679-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Temporal Pattern Generation; Oscillations; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Glutamate; I T low threshold; Gaba; Glutamate;
/
lytton97
README
AMPA.mod
calciumpump_destexhe.mod *
GABAB1.mod
GABALOW.mod
gen.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
nmda.mod
passiv.mod
presyn.mod *
pulse.mod *
rand.mod
boxes.hoc *
declist.hoc *
decvec.hoc *
default.hoc *
directory
fig7.gif
geom.hoc
grvec.hoc
init.hoc
jnphys77_1679.pdf
local.hoc *
mosinit.hoc
network.hoc
nrnoc.hoc *
params.hoc
presyn.inc *
queue.inc *
run.hoc
simctrl.hoc *
snshead.inc *
synq.inc *
xtmp
                            
NEURON {  POINT_PROCESS GABALOW }
:   GABA SYNAPSE (GABA-A receptors)
:
:   Parameters estimated from whole cell recordings of GABA-A synaptic currents 
:   from dentate granule cells: Otis TS and Mody I (1992) Modulation of decay 
:   kinetics and frequency of GABA_A receptor-mediated spontaneous inhibitory
:   postsynaptic currents in hippocampal neurons.  Neurosci. 49: 13-32.
:
:   GABALOW was created to allow the use two types of GABA-A currents in the
:   same simulation.
PARAMETER {
  Cmax	= 1	(mM)		: max transmitter concentration
  Cdur	= 1.0	(ms)		: transmitter duration (rising phase)
  Alpha	= 0.53	(/ms mM)	: forward (binding) rate
  Beta	= 0.18	(/ms)		: backward (unbinding) rate
  Erev	= -80	(mV)		: reversal potential
  Prethresh = 0 			: voltage level nec for release
  Deadtime = 1	(ms)		: mimimum time between release events
  gmax		(umho)		: maximum conductance
}
INCLUDE "synq.inc"
:________________________________________________________________

Loading data, please wait...