Thalamic quiescence of spike and wave seizures (Lytton et al 1997)

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Accession:9889
A phase plane analysis of a two cell interaction between a thalamocortical neuron (TC) and a thalamic reticularis neuron (RE).
Reference:
1 . Lytton WW, Contreras D, Destexhe A, Steriade M (1997) Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J Neurophysiol 77:1679-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Temporal Pattern Generation; Oscillations; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Glutamate; I T low threshold; Gaba; Glutamate;
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lytton97
README
AMPA.mod
calciumpump_destexhe.mod *
GABAB1.mod
GABALOW.mod
gen.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
nmda.mod
passiv.mod
presyn.mod *
pulse.mod *
rand.mod
boxes.hoc *
declist.hoc *
decvec.hoc *
default.hoc *
directory
fig7.gif
geom.hoc
grvec.hoc
init.hoc
jnphys77_1679.pdf
local.hoc *
mosinit.hoc
network.hoc
nrnoc.hoc *
params.hoc
presyn.inc *
queue.inc *
run.hoc
simctrl.hoc *
snshead.inc *
synq.inc *
xtmp
                            
/* $Id: geom.hoc,v 1.5 1994/10/05 18:28:14 billl Exp $ */

print " "
print " << defining templates: REcell, TCcell, Tcol >> "
print " "

// DO NOT TOUCH "tiers" outside this file
// after loading geom.hoc it is hard-wired
tiers = 1  // number of tiers of TC cells in a column
func ftiers() {return tiers}  // to communicate with templates

/*--------------------------------------------------------------
	TEMPLATE FILE FOR RE CELL
--------------------------------------------------------------*/

begintemplate REcell		/* create a new template object... */
public soma, slgaba, srgaba, sglu, slglu, srglu, tiers
external ftiers

create soma

tiers = ftiers()
objectvar sglu[tiers]  // syns within column
objectvar slglu  // syns to left sided column
objectvar srglu  // syns to right sided column
objectvar slgaba  // syns to RE left
objectvar srgaba  // syns to RE right

proc init() { local v_potassium, v_sodium

  tiers = ftiers()
  v_potassium = -95	/* potassium reversal potential */
  v_sodium = 50		/* sodium reversal potential */

  soma {
	Ra = 100		/* geometry */
	nseg = 1
	diam = 10
	L = 31.831  		/* such as surface = 1000 um2 */
  }

  slgaba = new GABALOW()   // have to be connected from outside
  soma slgaba.loc(0.5)	// hook for L col
  srgaba = new GABALOW()	// hook for R col
  soma srgaba.loc(0.5)

  slglu = new AMPA()   // have to be connected from outside
  soma slglu.loc(0.5)	// hook for L col
  srglu = new AMPA()	// hook for R col
  soma srglu.loc(0.5)
    
  for(i=0; i<tiers; i=i+1) {
    sglu[i] = new AMPA()         /* internal connect */
    soma sglu[i].loc(0.5)
  }
}

endtemplate REcell

/*--------------------------------------------------------------
	TEMPLATE FILE FOR TC CELL
--------------------------------------------------------------*/

begintemplate TCcell		/* create a new template object... */
public soma, sgaba, sgabab, slgaba, srgaba, tier

create soma
objectvar sgaba, sgabab, slgaba, srgaba                  // single retic input

proc init() { local v_potassium, v_sodium

  tier = $1

  v_potassium = -95	/* potassium reversal potential */
  v_sodium = 50		/* sodium reversal potential */

  soma {
	Ra = 100		/* geometry */
	nseg = 1
	diam = 10
	L = 31.831  		/* such as surface = 1000 um2 */
  }

  // cell 0 receives projection from L, doesn't project out of col
  if (tier == 0) {
    slgaba = new GABALOW()  // have to be connected from outside
    soma slgaba.loc(0.5)	/* hook for L col */
  } 

  // cell 1 receives projection from R, projects to L
  // cell 2 receives no lat projection, projects to R
  if (tier == 1) {
    srgaba = new GABALOW()	/* hook for R col */
    soma srgaba.loc(0.5)
  }

  sgaba = new GABALOW()        /* projection from RE heading column */
  soma sgaba.loc(0.5)
  sgabab = new GABAB1()        /* projection from RE heading column */
  soma sgabab.loc(0.5)

}
endtemplate TCcell

/*--------------------------------------------------------------
	TEMPLATE FILE FOR DEFINING THALAMIC COLUMN
--------------------------------------------------------------*/

begintemplate Tcol
public re, tc, tiers, col
external ftiers

tiers = ftiers()
objectvar re, tc[tiers]

proc init() { local i
  col = $1
  tiers = ftiers()
  re = new REcell()
  for(i=0; i<tiers; i=i+1) {
    tc[i] = new TCcell(i)
  }
  // provide the connectivity within the column
  for(i=0; i<tiers; i=i+1) {
    setpointer re.sglu[i].pre, tc[i].soma.v(0.5) /* presynaptic is TC */    
    setpointer tc[i].sgaba.pre, re.soma.v(0.5)	 /* presynaptic is RE */
    setpointer tc[i].sgabab.pre, re.soma.v(0.5)	 /* presynaptic is RE */
  }
}
endtemplate Tcol


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