Thalamic quiescence of spike and wave seizures (Lytton et al 1997)

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Accession:9889
A phase plane analysis of a two cell interaction between a thalamocortical neuron (TC) and a thalamic reticularis neuron (RE).
Reference:
1 . Lytton WW, Contreras D, Destexhe A, Steriade M (1997) Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J Neurophysiol 77:1679-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Temporal Pattern Generation; Oscillations; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Glutamate; I T low threshold; Gaba; Glutamate;
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lytton97
README
AMPA.mod
calciumpump_destexhe.mod *
GABAB1.mod
GABALOW.mod
gen.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
nmda.mod
passiv.mod
presyn.mod *
pulse.mod *
rand.mod
boxes.hoc *
declist.hoc *
decvec.hoc *
default.hoc *
directory
fig7.gif
geom.hoc
grvec.hoc
init.hoc
jnphys77_1679.pdf
local.hoc *
mosinit.hoc
network.hoc
nrnoc.hoc *
params.hoc
presyn.inc *
queue.inc *
run.hoc
simctrl.hoc *
snshead.inc *
synq.inc *
xtmp
                            
: $Id: snshead.inc,v 1.22 1998/01/07 20:22:30 billl Exp $

VERBATIM

#define PSTCAST ((SynS *)((unsigned long) lpst))
#define QUECAST ((QueU *)((unsigned long) queu))
#define PRECAST ((PreL *)((unsigned long) link))
#define QPRCAST ((QptR *)((unsigned long) qptr))

#define PREINC  50.  /* size increment for growing the presyn array */
#define POSTINC 5.   /* size increment for growing the postsyn array */

typedef struct QueU { /* postsynaptic queue */
  double time;  /* records spike time + delay */
  short index;  /* records index of associated SynS struct */
} QueU;

/* holds all the info for accessing the queu and its tail */
typedef struct QptR {
  struct QueU *qq;     /* will point to the queu */
  double *nspk; /* will point to newspk */
  double *head; /* will point to begsyn */
  double *qln;  /* points to qlen */
  double dead;  /* Cdur + Deadtime */
  double qterm;  /* the last time put on this queue */
  int cpost;  /* user code for info about postsyn cell */
} QptR;

typedef struct SynS { /* postsynaptic structure */
  /* this stuff used presynaptically */
  short index;  /* index of this item */
  double del;   /* param: individualized delay set by user */
  double spkt;  /* state: time when next spike can begin */
  struct QptR *qpt;   /* indirection to get at the queu */

  /* for allowing mult spikes to add up */
  short chainlen;
  short chainptr;

  /* user codes */
  int ucode;  /* user code for user convenience, an arbitrary index */
  /* this stuff used postsynaptically */
  double pgm;   /* percent of gmax - set by user */
  double Rcurr; /* holds current value of R (release status), internal */
  double last;  /* time last syn will end, internal */
  int *pcpre;   /* pointer to access the presyn code */
  struct SynS **back;  /* pointer to presyn pointer to this entry */
} SynS;

/* holds all the info for accessing presyn list */
typedef struct PreL {
  int cpre;   /* user code for info about presyn cell */
  struct SynS **plst;        /* will point to post for postsyn nrn*/
  double *nnpre;     /* number of pointers currently there */
  double *mxpre;     /* number permitted before realloc required */
  double link2;       /* a copy of the link information to confirm correct hook up */
} PreL;

ENDVERBATIM

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