Thalamic quiescence of spike and wave seizures (Lytton et al 1997)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:9889
A phase plane analysis of a two cell interaction between a thalamocortical neuron (TC) and a thalamic reticularis neuron (RE).
Reference:
1 . Lytton WW, Contreras D, Destexhe A, Steriade M (1997) Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J Neurophysiol 77:1679-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Temporal Pattern Generation; Oscillations; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Glutamate; I T low threshold; Gaba; Glutamate;
/
lytton97
README
AMPA.mod
calciumpump_destexhe.mod *
GABAB1.mod
GABALOW.mod
gen.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
nmda.mod
passiv.mod
presyn.mod *
pulse.mod *
rand.mod
boxes.hoc *
declist.hoc *
decvec.hoc *
default.hoc *
directory
fig7.gif
geom.hoc
grvec.hoc
init.hoc
jnphys77_1679.pdf
local.hoc *
mosinit.hoc
network.hoc
nrnoc.hoc *
params.hoc
presyn.inc *
queue.inc *
run.hoc
simctrl.hoc *
snshead.inc *
synq.inc *
xtmp
                            
// $Id: boxes.hoc,v 1.20 2001/01/22 21:02:37 billl Exp $

proc boxes () {}

// factor(num) finds the factors that are closest together
// NB: must be at top since declared external in template BX
func factor () { local num, srt, ii
  num = $1
  srt = int(sqrt(num))
  for (ii=srt;ii<num && num/ii!=int(num/ii);ii+=1) {}
  if (ii>num/ii) ii=num/ii // return smaller factor
  return ii
}

// template for putting up trays and decks
begintemplate BX
public mktray,mkdeck,name,boxes
public min,max,attrnum,rows,cols
external rv,gv,factor

objref boxl, boxes[3], ob, gitem
double min[1],max[1]
strdef temp_string_,name

proc init () {
  min = -1 max = -1
  boxl = new List()
}

//mktray(panattr) graph out from llist of a panattr
proc mktray () { local ci, ri, gi, m1, m2, bi
  attrnum=$2
  ob = $o1.object($2)
  cols=$4 rows=$3
  if (numarg()==6) {xs=$5 ys=$6} else {xs=100 ys=50}
  ri = 0 // count the rows
  gi = 0 // count the graphs
  boxes[0] = new VBox()
  boxes[0].intercept(1)
  name="                "
  xpanel("",1)
  xvarlabel(name)
  xpanel()
    for ri=0,rows-1 {
    boxes[2] = new HBox()
    boxl.append(boxes[2])
    bi = boxl.count-1
    boxl.object(bi).intercept(1)
    for ci=0,cols-1 {
      gitem = new Graph(0)
      gitem.view(0,-100,1000,50,0,0,xs,ys)
      ob.glist.append(gitem)
      gi = gi+1
    }
    boxl.object(bi).intercept(0)
    boxl.object(bi).map("")
  }
  boxes[0].intercept(0)
  if (strcmp(name,"")==0) boxes[0].map(ob.filename) else {
    boxes[0].map(name) }
}

proc mkdeck () { local rows, cols, ci, ri, gi, m1, m2
  ob = $o1.object($2)
  if (min==-1 || max==-1) {
    m1 = 0 m2 = ob.llist.count()-1
  } else { m1=min    m2=max }
  cnt = m2-m1+1
  cols=factor(cnt) rows=cnt/factor(cnt)
  ri = 0 // count the rows
  gi = 0 // count the graphs
  boxes[0] = new VBox()
  boxes[0].intercept(1)
  xpanel("",1)
  xbutton("Next","boxes[1].flip_to(decknum=decknum+1)")
  xbutton("Previous","boxes[1].flip_to(decknum=decknum-1)")
  xpanel()
  boxes[1] = new Deck()
  boxes[1].intercept(1)
  for ri=0,rows-1 {
    boxes[2] = new HBox()
    boxl.append(boxes[2])
    boxes[2].intercept(1)
    for ci=0,cols-1 {
      rv($2,gi+m1)
      gi = gi+1
    }
    boxes[2].intercept(0)
    boxes[2].map("")
  }
  boxes[1].intercept(0)
  boxes[1].map("")
  boxes[0].intercept(0)
  boxes[0].map("Deck")
  decknum = 0
  boxes[1].flip_to(decknum)
  if ($2!=0) {
    for ii = 0,gi-1 { 
      ob.glist.object(ii).label(0.3,0.5,ob.llist.object(ii).name)
    }
  }
}

endtemplate BX

objref boxer, boxerl
boxerl = new List()
proc mktray () { 
  if (numarg()==0) { print "mktray(attrnum,rows,cols[,xsize,ysize,label])"
    print "Create a tray for attr panel ATTRNUM to superimpose upon."
    return }
  boxer = new BX()
  boxerl.append(boxer)
  if ($1>panobjl.count-1) {
    attrlist(5,$1,"NEW","",printStep)
  }
  panobjl.object($1).super = 1
  if (numarg()==4) { boxer.name=$s4 }
  if (numarg()==6) { boxer.name=$s6 }
  if (numarg()>3 && numarg()!=4) {
    boxer.mktray(panobjl,$1,$2,$3,$4,$5)
  } else {
    boxer.mktray(panobjl,$1,$2,$3)
  }
  boxer=nil
}

proc rmtray () { local attrnum
  attrnum=$1
  if (boxerl.count<=1) boxerl.remove_all else {
    for (ii=boxerl.count-1;ii>=0;ii-=1) {
      if (boxerl.object(ii).attrnum==attrnum) boxerl.remove(ii) 
    }}
  remgrs(attrnum)
  panobj.super=0
}

proc trsz () {
  if (boxerl.count>0) for ltr (XO,boxerl) printf("%d:%d x %d\n",XO.attrnum,XO.rows,XO.cols)
}

proc mktrpanl () {
  xgetargs("Make Tray","mktray","Which","rows","cols","xsize","ysize","0,2,3,100,50")
}

lastdisp = 0
proc disptray () { local ii,jj,kk
  if (numarg()==0) {print "disptray(attrnum[,cols])" return}
  lastdisp=attrnum=$1
  ii=panobjl.object(attrnum).llist.count 
  if (numarg()==2) jj=$2 else jj=factor(ii)
  kk=panobjl.object(attrnum).glist.count
  mktray(attrnum,ii/jj,jj,100,50) 
  grall(attrnum,0,ii-1,attrnum,kk)
  for ltr(XO,panobjl.object(attrnum).glist) if(i1>=kk) { 
    XO.size(&x[0]) 
    XO.size(x[0],x[1],x[2],x[3]) }
}

proc redisptr () { 
  if (numarg()==1) lastdisp=$1
  geall(lastdisp) grall(lastdisp)
}

Lytton WW, Contreras D, Destexhe A, Steriade M (1997) Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J Neurophysiol 77:1679-96[PubMed]

References and models cited by this paper

References and models that cite this paper

Avanzini G, de Curtis M, Panzica F, Spreafico R (1989) Intrinsic properties of nucleus reticularis thalami neurones of the rat studied in vitro. J Physiol 416:111-22 [PubMed]

Bal T, McCormick DA (1993) Mechanisms of oscillatory activity in guinea-pig nucleus reticularis thalami in vitro: a mammalian pacemaker. J Physiol 468:669-91 [PubMed]

Contreras D, Steriade M (1996) Spindle oscillation in cats: the role of corticothalamic feedback in a thalamically generated rhythm. J Physiol 490 ( Pt 1):159-79 [PubMed]

Coulter DA, Huguenard JR, Prince DA (1989) Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol 414:587-604 [PubMed]

Crunelli V, Lightowler S, Pollard CE (1989) A T-type Ca2+ current underlies low-threshold Ca2+ potentials in cells of the cat and rat lateral geniculate nucleus. J Physiol 413:543-61 [PubMed]

Davies CH, Davies SN, Collingridge GL (1990)

Deschaenes M, Madariaga-Domich A, Steriade M (1985) Dendrodendritic synapses in the cat reticularis thalami nucleus: a structural basis for thalamic spindle synchronization. Brain Res 334:165-8 [PubMed]

Destexhe A, Babloyantz A, Sejnowski TJ (1993) Ionic mechanisms for intrinsic slow oscillations in thalamic relay neurons. Biophys J 65:1538-52 [PubMed]

Destexhe A, Bal T, McCormick DA, Sejnowski TJ (1996) Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. J Neurophysiol 76:2049-70 [Journal] [PubMed]

   Thalamocortical and Thalamic Reticular Network (Destexhe et al 1996) [Model]

Destexhe A, Contreras D, Sejnowski TJ, Steriade M (1994) Modeling the control of reticular thalamic oscillations by neuromodulators. Neuroreport 5:2217-20 [PubMed]

Destexhe A, Contreras D, Sejnowski TJ, Steriade M (1994) A model of spindle rhythmicity in the isolated thalamic reticular nucleus. J Neurophysiol 72:803-18 [Journal] [PubMed]

   Thalamic Reticular Network (Destexhe et al 1994) [Model]

Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci 16:169-85 [Journal] [PubMed]

   [1 reconstructed morphology on NeuroMorpho.Org]
   Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996) [Model]

Destexhe A, Mainen ZF, Sejnowski TJ (1994) Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. J Comput Neurosci 1:195-230 [Journal] [PubMed]

   Application of a common kinetic formalism for synaptic models (Destexhe et al 1994) [Model]
   Kinetic synaptic models applicable to building networks (Destexhe et al 1998) [Model]

Destexhe A, McCormick DA, Sejnowski TJ (1993) A model for 8-10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophys J 65:2473-7 [Journal] [PubMed]

Destexhe A, Sejnowski TJ (1995) G protein activation kinetics and spillover of gamma-aminobutyric acid may account for differences between inhibitory responses in the hippocampus and thalamus. Proc Natl Acad Sci U S A 92:9515-9 [PubMed]

Dichter M, Spencer WA (1969)

Dutar P, Nicoll RA (1988)

Fisher RS, Prince DA (1977)

Gloor P (1979)

Golomb D, Wang XJ, Rinzel J (1994) Synchronization properties of spindle oscillations in a thalamic reticular nucleus model. J Neurophysiol 72:1109-26 [Journal] [PubMed]

Golomb D, Wang XJ, Rinzel J (1996) Propagation of spindle waves in a thalamic slice model. J Neurophysiol 75:750-69 [Journal] [PubMed]

Hernandez-Cruz A, Pape HC (1989) Identification of two calcium currents in acutely dissociated neurons from the rat lateral geniculate nucleus. J Neurophysiol 61:1270-83 [Journal] [PubMed]

Hirsch MW, Baird B (1995)

Huguenard JR, Prince DA (1992) A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. J Neurosci 12:3804-17 [PubMed]

Huguenard JR, Prince DA (1994) Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis. J Neurophysiol 71:2576-81 [Journal] [PubMed]

Jahnsen H, Llinas R (1984) Ionic basis for the electro-responsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro. J Physiol 349:227-47 [PubMed]

Jahnsen H, Llinas R (1984) Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study. J Physiol 349:205-26 [PubMed]

Kim U, Bal T, McCormick DA (1995)

LeMasson G, Marder E, Abbott LF (1993)

Leresche N, Lightowler S, Soltesz I, Jassik-Gerschenfeld D, Crunelli V (1991) Low-frequency oscillatory activities intrinsic to rat and cat thalamocortical cells. J Physiol 441:155-74 [PubMed]

Lytton WW (1996) Optimizing synaptic conductance calculation for network simulations. Neural Comput 8:501-9 [PubMed]

Lytton WW, Destexhe A, Sejnowski TJ (1996) Control of slow oscillations in the thalamocortical neuron: a computer model. Neuroscience 70:673-84 [PubMed]

Lytton WW, Sejnowski TJ (1991) Simulations of cortical pyramidal neurons synchronized by inhibitory interneurons. J Neurophysiol 66:1059-79 [Journal] [PubMed]

McCormick DA, Pape HC (1990) Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol 431:291-318 [PubMed]

   Thalamic Relay Neuron: I-h (McCormick, Pape 1990) [Model]

Mody I, De Koninck Y, Otis TS, Soltesz I (1994)

Rush ME, Rinzel J (1994)

Shosaku A (1986)

Soltesz I, Crunelli V (1992) A role for low-frequency, rhythmic synaptic potentials in the synchronization of cat thalamocortical cells. J Physiol 457:257-76 [PubMed]

Steriade M, Amzica F (1994) Dynamic coupling among neocortical neurons during evoked and spontaneous spike-wave seizure activity. J Neurophysiol 72:2051-69 [Journal] [PubMed]

Steriade M, Contreras D (1995) Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity. J Neurosci 15:623-42 [PubMed]

Steriade M, Deschaenes M, Domich L, Mulle C (1985) Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami. J Neurophysiol 54:1473-97 [Journal] [PubMed]

Steriade M, Domich L, Oakson G (1986) Reticularis thalami neurons revisited: activity changes during shifts in states of vigilance. J Neurosci 6:68-81 [PubMed]

Steriade M, Domich L, Oakson G, Deschaenes M (1987) The deafferented reticular thalamic nucleus generates spindle rhythmicity. J Neurophysiol 57:260-73 [Journal] [PubMed]

Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262:679-85 [PubMed]

Suzuki S, Rogawski MA (1989)

Traub RD, Miles R, Wong RK (1987) Models of synchronized hippocampal bursts in the presence of inhibition. I. Single population events. J Neurophysiol 58:739-51 [Journal] [PubMed]

Traub RD, Miles R, Wong RK, Schulman LS, Schneiderman JH (1987) Models of synchronized hippocampal bursts in the presence of inhibition. II. Ongoing spontaneous population events. J Neurophysiol 58:752-64 [Journal] [PubMed]

Ulrich D, Huguenard JR (1996)

von Krosigk M, Bal T, McCormick DA (1993) Cellular mechanisms of a synchronized oscillation in the thalamus. Science 261:361-4 [PubMed]

Wallenstein GV (1994)

Wang XJ, Golomb D, Rinzel J (1995) Emergent spindle oscillations and intermittent burst firing in a thalamic model: specific neuronal mechanisms. Proc Natl Acad Sci U S A 92:5577-81 [PubMed]

Yen CT, Conley M, Hendry SH, Jones EG (1985) The morphology of physiologically identified GABAergic neurons in the somatic sensory part of the thalamic reticular nucleus in the cat. J Neurosci 5:2254-68 [PubMed]

Destexhe A (1998) Spike-and-wave oscillations based on the properties of GABAB receptors. J Neurosci 18:9099-111 [PubMed]

Destexhe A, Contreras D, Steriade M (2001) LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38:555-563 [Journal]

   Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001) [Model]

Destexhe A, Sejnowski TJ (2003) Interactions between membrane conductances underlying thalamocortical slow-wave oscillations. Physiol Rev 83:1401-53 [PubMed]

Hines ML, Carnevale NT (2003) Personal Communication of NEURON bibliography

Huertas MA, Groff JR, Smith GD (2005) Feedback Inhibition and Throughput Properties of an Integrate-and-Fire-or-Burst Network Model of Retinogeniculate Transmission J Comp Neurosci 19:147-180 [Journal]

Kager H, Wadman WJ, Somjen GG (2007) Seizure-like afterdischarges simulated in a model neuron. J Comput Neurosci 22:105-128 [Journal] [PubMed]

Le Franc Y, Le Masson G (2010) Multiple firing patterns in deep Dorsal Horn Neurons of the spinal cord: computational analysis of mechanisms and functional implications. J Neurophysiol [Journal] [PubMed]

Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [Journal] [PubMed]

   Computer model of clonazepam`s effect in thalamic slice (Lytton 1997) [Model]

Lytton WW, Hellman KM, Sutula TP (1998) Computer models of hippocampal circuit changes of the kindling model of epilepsy. Artif Intell Med 13:81-97 [PubMed]

Lytton WW, Seidenstein AH, Dura-Bernal S, McDougal RA, Schurmann F, Hines ML (2016) Simulation Neurotechnologies for Advancing Brain Research: Parallelizing Large Networks in NEURON. Neural Comput :1-28 [Journal] [PubMed]

   Parallelizing large networks in NEURON (Lytton et al. 2016) [Model]

Suffczynski P, Kalitzin S, Lopes Da Silva FH (2004) Dynamics of non-convulsive epileptic phenomena modeled by a bistable neuronal network. Neuroscience 126:467-84 [Journal] [PubMed]

   Thalamocortical model of spike and wave seizures (Suffczynski et al. 2004) [Model]

Thomas E, Lytton WW (1998) Computer model of antiepileptic effects mediated by alterations in GABA(A)-mediated inhibition. Neuroreport 9:691-6 [PubMed]

van Drongelen W, Lee HC, Stevens RL, Hereld M (2007) propagation of seizure-like activity in a model of neocortex. J Clin Neurophysiol 24:182-8 [PubMed]

Zhao X, Robinson PA (2015) Generalized seizures in a neural field model with bursting dynamics. J Comput Neurosci [Journal] [PubMed]

   Neural-field model of generalized seizures (Zhao et al., 2015) [Model]

(66 refs)