O-LM interneuron model (Lawrence et al. 2006)

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Accession:102288
Exploring the kinetics and distribution of the muscarinic potassium channel, IM, in 2 O-LM interneuron morphologies. Modulation of the ion channel by drugs such as XE991 (antagonist) and retigabine (agonist) are simulated in the models to examine the role of IM in spiking properties.
Reference:
1 . Lawrence JJ, Saraga F, Churchill JF, Statland JM, Travis KE, Skinner FK, McBain CJ (2006) Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. J Neurosci 26:12325-38 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 interneuron oriens alveus GABA cell;
Channel(s): I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca;
Gap Junctions:
Receptor(s): Muscarinic;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Oscillations; Detailed Neuronal Models; Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 interneuron oriens alveus GABA cell; Muscarinic; I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca;
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RichyandStarfish
readme.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
SIN.mod *
fig9.hoc
initactiveproxRichy.hoc
initactiveproxStarfish.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initsomaRichy.hoc
initsomaStarfish.hoc
mosinit.hoc
Richytrunctest2.hoc
screenshot.jpg
Starfishtrunc.hoc
                            
UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
}
 
NEURON {
        SUFFIX IMminret
        USEION k READ ek WRITE ik
        RANGE gbar,ik, vhalf1, vhalf2, k1, k2, c1, c2
        GLOBAL minf, mtau
}
 
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
 
PARAMETER {
        v (mV)
        dt (ms)
        gbar = 0.001 (mho/cm2)		
	ek
	mmin = 7	(ms)
	vhalf1 = -63
	vhalf2 = -63
	k1 = 15
	k2 = 15
	c1 = 0.003
	c2 = 0.003
}
 
STATE {
        m
}
 
ASSIGNED {
	ik
	minf 
	mtau	(ms)
}
 
BREAKPOINT {
        SOLVE state METHOD cnexp
        ik = gbar*m*(v - ek)
}
 
INITIAL {
	rates(v)
	m = minf
}

DERIVATIVE state { :Computes state variable h at current v and dt.
	rates(v)
	m' = (minf - m)/mtau
}

PROCEDURE rates(v(mV)) {  :Computes rate and other constants at current v.
                      :Call once from HOC to initialize inf at resting v.
:        TABLE rinf, rexp, tau_r DEPEND dt, p FROM -200 TO 100 WITH 300
	LOCAL a, b
	minf = 1/(1 + exp(-(v+60(mV))/7(mV)))
	a = c1/exp(-(v-vhalf1)/k1)
	b = c2/exp((v-vhalf2)/k2)
	mtau = 1/(a+b)
	if (mtau<mmin) {mtau = mmin}
}
 
UNITSON


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